suramin has been researched along with Pheochromocytoma, Extra-Adrenal in 7 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Human pheochromocytoma and PC12 rat pheochromocytoma cells were grown in medium supplemented with suramin at concentrations of 1-1,000 micrograms/ml (1." | 7.69 | Antiproliferative effect of suramin on primary cultures of human pheochromocytomas and rat PC12 pheochromocytoma cells. ( Clark, OH; Duh, QY; Rothmund, M; Siperstein, AE; Wong, MG; Zielke, A, 1997) |
| "Human pheochromocytoma and PC12 rat pheochromocytoma cells were grown in medium supplemented with suramin at concentrations of 1-1,000 micrograms/ml (1." | 3.69 | Antiproliferative effect of suramin on primary cultures of human pheochromocytomas and rat PC12 pheochromocytoma cells. ( Clark, OH; Duh, QY; Rothmund, M; Siperstein, AE; Wong, MG; Zielke, A, 1997) |
| "Suramin is an experimental antineoplastic agent which is currently being tested in clinical trials for its utility in treating breast and prostate cancer." | 1.30 | Role of ceramide in suramin-induced cancer cell death. ( Gill, JS; Windebank, AJ, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Koizumi, S | 1 |
| Nakazawa, K | 4 |
| Inoue, K | 4 |
| Zielke, A | 1 |
| Wong, MG | 1 |
| Siperstein, AE | 1 |
| Clark, OH | 1 |
| Rothmund, M | 1 |
| Duh, QY | 1 |
| Gill, JS | 1 |
| Windebank, AJ | 1 |
| Fujimori, K | 3 |
| Takanaka, A | 3 |
| Schwartz, RW | 1 |
| Sloan, DA | 1 |
| Kenady, DE | 1 |
1 review available for suramin and Pheochromocytoma, Extra-Adrenal
| Article | Year |
|---|---|
Diagnosis and treatment of primary adrenal tumors.
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Adult; Aged; Carcinoma; Cushing Syndrome; Diagnosis | 1991 |
6 other studies available for suramin and Pheochromocytoma, Extra-Adrenal
| Article | Year |
|---|---|
Inhibition by Zn2+ of uridine 5'-triphosphate-induced Ca(2+)-influx but not Ca(2+)-mobilization in rat phaeochromocytoma cells.
Topics: Adenosine Triphosphate; Adrenal Gland Neoplasms; Animals; Calcium; Cells, Cultured; Dopamine; Dose-R | 1995 |
Antiproliferative effect of suramin on primary cultures of human pheochromocytomas and rat PC12 pheochromocytoma cells.
Topics: Adrenal Gland Neoplasms; Animals; Antineoplastic Agents; Cell Division; Cell Survival; Drug Screenin | 1997 |
Role of ceramide in suramin-induced cancer cell death.
Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Survival; Ceramides; DNA Fragmenta | 1997 |
Effects of ATP antagonists on purinoceptor-operated inward currents in rat phaeochromocytoma cells.
Topics: Adenosine Triphosphate; Adrenal Gland Neoplasms; Animals; Electric Conductivity; Ion Channels; Kinet | 1991 |
Comparison of adenosine triphosphate- and nicotine-activated inward currents in rat phaeochromocytoma cells.
Topics: Adenosine Triphosphate; Animals; Biological Transport, Active; Hexamethonium Compounds; Nerve Growth | 1991 |
Reversible and selective antagonism by suramin of ATP-activated inward current in PC12 phaeochromocytoma cells.
Topics: Adenosine Triphosphate; Adrenal Gland Neoplasms; Animals; Cell Membrane; Methacholine Compounds; Nic | 1990 |