suramin has been researched along with Peripheral Nerve Diseases in 13 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In order to determine if the endogenous opioid system is involved in this antinociception, naloxone was administered just prior to the injection of a selective P2X3/P2X2/3 receptor antagonist, A-317491, in rat models of neuropathic, chemogenic, and inflammatory pain." | 3.73 | Endogenous opioid mechanisms partially mediate P2X3/P2X2/3-related antinociception in rat models of inflammatory and chemogenic pain but not neuropathic pain. ( Bianchi, B; Faltynek, CR; Honore, P; Jarvis, MF; McDonald, HA; McGaraughty, S; Mikusa, J; Wismer, CT; Zhu, CZ, 2005) |
| "Suramin is an investigational drug that has shown therapeutic activity in hormone-refractory metastatic prostate cancer in Phase I/II trials." | 2.68 | A prospective study of suramin-induced peripheral neuropathy. ( Chaudhry, V; Cornblath, DR; Eisenberger, MA; Griffin, JW; Sheikh, K; Sinibaldi, VJ, 1996) |
| "Peripheral neurotoxicity is a crucial side effect of chemotherapeutic agents." | 2.41 | [Peripheral nervous system neurotoxicity secondary to chemotherapy treatment] . ( Iñiguez, C; Larrodé, P; Mauri, JA; Mayordomo, JI; Morales, F; Trés, A, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (30.77) | 18.2507 |
| 2000's | 9 (69.23) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Peltier, AC | 1 |
| Russell, JW | 3 |
| Joseph, EK | 1 |
| Chen, X | 1 |
| Khasar, SG | 1 |
| Levine, JD | 1 |
| Cavaletti, G | 1 |
| Marmiroli, P | 1 |
| McGaraughty, S | 1 |
| Honore, P | 1 |
| Wismer, CT | 1 |
| Mikusa, J | 1 |
| Zhu, CZ | 1 |
| McDonald, HA | 1 |
| Bianchi, B | 1 |
| Faltynek, CR | 1 |
| Jarvis, MF | 1 |
| Schröder, JM | 1 |
| Toyka, KV | 1 |
| Hartung, HP | 2 |
| Windebank, AJ | 2 |
| Podratz, JL | 1 |
| Chaudhry, V | 1 |
| Eisenberger, MA | 1 |
| Sinibaldi, VJ | 1 |
| Sheikh, K | 1 |
| Griffin, JW | 1 |
| Cornblath, DR | 1 |
| Stanfa, LC | 1 |
| Kontinen, VK | 1 |
| Dickenson, AH | 1 |
| Park, SK | 1 |
| Chung, K | 1 |
| Chung, JM | 1 |
| Iñiguez, C | 1 |
| Larrodé, P | 1 |
| Mayordomo, JI | 1 |
| Mauri, JA | 1 |
| Trés, A | 1 |
| Morales, F | 1 |
| Gill, JS | 1 |
| Sorenson, EJ | 1 |
| Schultz, DA | 1 |
| Quasthoff, S | 1 |
| La Rocca, RV | 1 |
| Meer, J | 1 |
| Gilliatt, RW | 1 |
| Stein, CA | 1 |
| Cassidy, J | 1 |
| Myers, CE | 1 |
| Dalakas, MC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Investigation of the Effect of Chemotherapy-induced Peripheral Neuropathy (CIPN) on Sensory and Motor Function in Patients With Cancer[NCT04799080] | 72 participants (Actual) | Observational | 2021-03-06 | Completed | |||
| The Use of Cryotherapy to Prevent Paclitaxel-induced Peripheral Neuropathy and Nail Changes in Women With Breast Cancer[NCT04558034] | 14 participants (Actual) | Interventional | 2020-08-04 | Terminated (stopped due to Principal Investigator retired before study completed.) | |||
| Randomized Phase III Clinical Trial of Weekly Versus Tri-weekly Cisplatin Based Chemoradiation in Locally Advanced Cervical Cancer[NCT01561586] | Phase 3 | 374 participants (Anticipated) | Interventional | 2012-03-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for suramin and Peripheral Nerve Diseases
| Article | Year |
|---|---|
Recent advances in drug-induced neuropathies.
Topics: Animals; Antineoplastic Agents; Cisplatin; Humans; Immunosuppressive Agents; Paclitaxel; Peripheral | 2002 |
Chemotherapy-induced peripheral neurotoxicity.
Topics: Animals; Antineoplastic Agents; Clinical Trials as Topic; Epothilones; Humans; Neoplasms; Neuroprote | 2004 |
[Peripheral nervous system neurotoxicity secondary to chemotherapy treatment] .
Topics: Anti-HIV Agents; Antineoplastic Agents; Cyclosporine; Depsipeptides; Docetaxel; Doxorubicin; Humans; | 2000 |
Chemotherapy-induced peripheral neuropathy.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Drug-Related Side Effects and | 2002 |
Chemotherapy-induced peripheral neuropathy.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Drug-Related Side Effects and | 2002 |
Chemotherapy-induced peripheral neuropathy.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Drug-Related Side Effects and | 2002 |
Chemotherapy-induced peripheral neuropathy.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Drug-Related Side Effects and | 2002 |
Chemotherapy-induced peripheral neuropathy.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Drug-Related Side Effects and | 2002 |
Chemotherapy-induced peripheral neuropathy.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Drug-Related Side Effects and | 2002 |
Chemotherapy-induced peripheral neuropathy.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Drug-Related Side Effects and | 2002 |
Chemotherapy-induced peripheral neuropathy.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Drug-Related Side Effects and | 2002 |
Chemotherapy-induced peripheral neuropathy.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Drug-Related Side Effects and | 2002 |
1 trial available for suramin and Peripheral Nerve Diseases
| Article | Year |
|---|---|
A prospective study of suramin-induced peripheral neuropathy.
Topics: Aged; Antineoplastic Agents; Axons; Clinical Trials as Topic; Humans; Male; Middle Aged; Neural Cond | 1996 |
8 other studies available for suramin and Peripheral Nerve Diseases
| Article | Year |
|---|---|
Novel mechanism of enhanced nociception in a model of AIDS therapy-induced painful peripheral neuropathy in the rat.
Topics: Aminoquinolines; Animals; Anti-HIV Agents; Antineoplastic Agents; Behavior, Animal; Calcium Channel | 2004 |
Endogenous opioid mechanisms partially mediate P2X3/P2X2/3-related antinociception in rat models of inflammatory and chemogenic pain but not neuropathic pain.
Topics: Analgesia; Animals; Arthritis, Experimental; Dose-Response Relationship, Drug; Endorphins; Formaldeh | 2005 |
11th meeting of the Peripheral Nerve Study Group (PNSG). "Klostergut Jakobsberg", Boppard, Germany 29 July-1 August 1993.
Topics: Animals; Cytokines; Humans; Neuritis; Neurons; Peripheral Nervous System Diseases; Polyradiculoneuro | 1995 |
Role of nerve growth factor in suramin neurotoxicity studied in vitro.
Topics: Animals; Ganglia, Spinal; Nerve Growth Factors; Neurites; Peripheral Nervous System Diseases; Rats; | 1994 |
Effects of spinally administered P2X receptor agonists and antagonists on the responses of dorsal horn neurones recorded in normal, carrageenan-inflamed and neuropathic rats.
Topics: Adenosine Triphosphate; Animals; Carrageenan; Electrophysiology; Inflammation; Injections, Spinal; M | 2000 |
Effects of purinergic and adrenergic antagonists in a rat model of painful peripheral neuropathy.
Topics: Adrenergic alpha-Antagonists; Animals; Antineoplastic Agents; Disease Models, Animal; Drug Therapy, | 2000 |
Suramin-induced neuropathy in an animal model.
Topics: Animals; Antineoplastic Agents; Axons; Cell Size; Disease Models, Animal; Dose-Response Relationship | 2001 |
Suramin-induced polyneuropathy.
Topics: Adult; Cerebrospinal Fluid Proteins; Female; Humans; Male; Middle Aged; Neoplasms; Neural Conduction | 1990 |