suramin has been researched along with Parasitemia in 5 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Parasitemia: The presence of parasites (especially malarial parasites) in the blood. (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The parasitemia was monitored daily through blood smear, and the treatment of all groups was performed three days post-infection (PI), when all mice showed increased parasitemia." | 1.39 | Susceptibility of Brazilian isolates of Trypanosoma evansi to suramin sodium: test in experimentally infected mice. ( Da Silva, AS; Faccio, L; Gressler, LT; Lazzarotto, CR; Miletti, LC; Monteiro, SG; Tonin, AA, 2013) |
| "Suramin was not effective." | 1.39 | Evaluation of trypanocidal drugs used for human African trypanosomosis against Trypanosoma lewisi. ( Bucheton, B; Courtois, P; Cuny, G; Daulouède, S; Dethoua, M; Nzoumbou-Boko, R; Semballa, S; Truc, P; Vincendeau, P, 2013) |
| "In human African trypanosomiasis (HAT), the parasites invade the central nervous system (CNS), leading to the development of meningo-encephalitis and an irreversible demyelinating process, which kills the patient unless specific treatment is undertaken." | 1.32 | Megazol combined with suramin improves a new diagnosis index of the early meningo-encephalitic phase of experimental African trypanosomiasis. ( Bourdon, L; Bouteille, B; Buguet, A; Chevrier, C; Darsaud, A; Dumas, M, 2004) |
| "Treatment of late-stage human African trypanosomiasis is complicated by the presence of trypanosomes within the central nervous system (CNS)." | 1.31 | Human African trypanosomiasis: potential therapeutic benefits of an alternative suramin and melarsoprol regimen. ( Bradley, B; Gettinby, G; Jennings, FW; Kennedy, PG; Murray, M; Rodgers, J, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Faccio, L | 1 |
| Da Silva, AS | 1 |
| Gressler, LT | 1 |
| Tonin, AA | 1 |
| Lazzarotto, CR | 1 |
| Miletti, LC | 1 |
| Monteiro, SG | 1 |
| Dethoua, M | 1 |
| Nzoumbou-Boko, R | 1 |
| Truc, P | 1 |
| Daulouède, S | 1 |
| Courtois, P | 1 |
| Bucheton, B | 1 |
| Cuny, G | 1 |
| Semballa, S | 1 |
| Vincendeau, P | 1 |
| Wise, E | 1 |
| Easom, N | 1 |
| Watson, J | 1 |
| Bailey, R | 1 |
| Brown, M | 1 |
| Jennings, FW | 1 |
| Rodgers, J | 1 |
| Bradley, B | 1 |
| Gettinby, G | 1 |
| Kennedy, PG | 1 |
| Murray, M | 1 |
| Darsaud, A | 1 |
| Chevrier, C | 1 |
| Bourdon, L | 1 |
| Dumas, M | 1 |
| Buguet, A | 1 |
| Bouteille, B | 1 |
5 other studies available for suramin and Parasitemia
| Article | Year |
|---|---|
Susceptibility of Brazilian isolates of Trypanosoma evansi to suramin sodium: test in experimentally infected mice.
Topics: Animals; Brazil; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Mice; Parasitemia | 2013 |
Evaluation of trypanocidal drugs used for human African trypanosomosis against Trypanosoma lewisi.
Topics: Animals; Eflornithine; Female; Humans; Immunocompromised Host; Inhibitory Concentration 50; Melarsop | 2013 |
Lesson of the month: a psychiatric diagnosis overturned by a blood film.
Topics: Antibodies, Protozoan; Cerebrospinal Fluid; Diagnosis, Differential; Female; Humans; Melarsoprol; Me | 2012 |
Human African trypanosomiasis: potential therapeutic benefits of an alternative suramin and melarsoprol regimen.
Topics: Animals; Anti-Infective Agents, Local; Drug Synergism; Drug Therapy, Combination; Female; Humans; Me | 2002 |
Megazol combined with suramin improves a new diagnosis index of the early meningo-encephalitic phase of experimental African trypanosomiasis.
Topics: Anemia; Animals; Body Weight; Drug Therapy, Combination; Eating; Hematocrit; Male; Meningoencephalit | 2004 |