Page last updated: 2024-11-04

suramin and Parasitemia

suramin has been researched along with Parasitemia in 5 studies

Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.

Parasitemia: The presence of parasites (especially malarial parasites) in the blood. (Dorland, 27th ed)

Research Excerpts

ExcerptRelevanceReference
"The parasitemia was monitored daily through blood smear, and the treatment of all groups was performed three days post-infection (PI), when all mice showed increased parasitemia."1.39Susceptibility of Brazilian isolates of Trypanosoma evansi to suramin sodium: test in experimentally infected mice. ( Da Silva, AS; Faccio, L; Gressler, LT; Lazzarotto, CR; Miletti, LC; Monteiro, SG; Tonin, AA, 2013)
"Suramin was not effective."1.39Evaluation of trypanocidal drugs used for human African trypanosomosis against Trypanosoma lewisi. ( Bucheton, B; Courtois, P; Cuny, G; Daulouède, S; Dethoua, M; Nzoumbou-Boko, R; Semballa, S; Truc, P; Vincendeau, P, 2013)
"In human African trypanosomiasis (HAT), the parasites invade the central nervous system (CNS), leading to the development of meningo-encephalitis and an irreversible demyelinating process, which kills the patient unless specific treatment is undertaken."1.32Megazol combined with suramin improves a new diagnosis index of the early meningo-encephalitic phase of experimental African trypanosomiasis. ( Bourdon, L; Bouteille, B; Buguet, A; Chevrier, C; Darsaud, A; Dumas, M, 2004)
"Treatment of late-stage human African trypanosomiasis is complicated by the presence of trypanosomes within the central nervous system (CNS)."1.31Human African trypanosomiasis: potential therapeutic benefits of an alternative suramin and melarsoprol regimen. ( Bradley, B; Gettinby, G; Jennings, FW; Kennedy, PG; Murray, M; Rodgers, J, 2002)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (40.00)29.6817
2010's3 (60.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Faccio, L1
Da Silva, AS1
Gressler, LT1
Tonin, AA1
Lazzarotto, CR1
Miletti, LC1
Monteiro, SG1
Dethoua, M1
Nzoumbou-Boko, R1
Truc, P1
Daulouède, S1
Courtois, P1
Bucheton, B1
Cuny, G1
Semballa, S1
Vincendeau, P1
Wise, E1
Easom, N1
Watson, J1
Bailey, R1
Brown, M1
Jennings, FW1
Rodgers, J1
Bradley, B1
Gettinby, G1
Kennedy, PG1
Murray, M1
Darsaud, A1
Chevrier, C1
Bourdon, L1
Dumas, M1
Buguet, A1
Bouteille, B1

Other Studies

5 other studies available for suramin and Parasitemia

ArticleYear
Susceptibility of Brazilian isolates of Trypanosoma evansi to suramin sodium: test in experimentally infected mice.
    Experimental parasitology, 2013, Volume: 134, Issue:3

    Topics: Animals; Brazil; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Mice; Parasitemia

2013
Evaluation of trypanocidal drugs used for human African trypanosomosis against Trypanosoma lewisi.
    Parasite (Paris, France), 2013, Volume: 20

    Topics: Animals; Eflornithine; Female; Humans; Immunocompromised Host; Inhibitory Concentration 50; Melarsop

2013
Lesson of the month: a psychiatric diagnosis overturned by a blood film.
    Clinical medicine (London, England), 2012, Volume: 12, Issue:3

    Topics: Antibodies, Protozoan; Cerebrospinal Fluid; Diagnosis, Differential; Female; Humans; Melarsoprol; Me

2012
Human African trypanosomiasis: potential therapeutic benefits of an alternative suramin and melarsoprol regimen.
    Parasitology international, 2002, Volume: 51, Issue:4

    Topics: Animals; Anti-Infective Agents, Local; Drug Synergism; Drug Therapy, Combination; Female; Humans; Me

2002
Megazol combined with suramin improves a new diagnosis index of the early meningo-encephalitic phase of experimental African trypanosomiasis.
    Tropical medicine & international health : TM & IH, 2004, Volume: 9, Issue:1

    Topics: Anemia; Animals; Body Weight; Drug Therapy, Combination; Eating; Hematocrit; Male; Meningoencephalit

2004