suramin has been researched along with Palsy in 2 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pretreatment with suramin (0." | 1.30 | Suramin inhibits the toxic effects of presynaptic neurotoxins at the mouse motor nerve terminals. ( Lin, MJ; Lin-Shiau, SY, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| de Oliveira, M | 1 |
| Cavalcante, WL | 1 |
| Arruda, EZ | 1 |
| Melo, PA | 1 |
| Dal-Pai Silva, M | 1 |
| Gallacci, M | 1 |
| Lin-Shiau, SY | 1 |
| Lin, MJ | 1 |
2 other studies available for suramin and Palsy
| Article | Year |
|---|---|
Antagonism of myotoxic and paralyzing activities of bothropstoxin-I by suramin.
Topics: Animals; Antivenins; Crotalid Venoms; Drug Antagonism; In Vitro Techniques; Male; Mice; Muscle, Skel | 2003 |
Suramin inhibits the toxic effects of presynaptic neurotoxins at the mouse motor nerve terminals.
Topics: Animals; Bungarotoxins; Diaphragm; Evoked Potentials; In Vitro Techniques; Membrane Potentials; Mice | 1999 |