suramin has been researched along with Osteosarcoma in 10 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Osteosarcoma: A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of suramin on tumor growth and morphology in two different human osteosarcoma xenografts (L-I OSM and L-II OSM) grown in BALB/cA-nu/nu mice was studied." | 7.68 | Suramin inhibits growth of human osteosarcoma xenografts in nude mice. ( Abdiu, A; Larsson, SE; Smeds, S; Walz, TM; Wasteson, A; Wingren, S, 1991) |
| "Suramin has in the last two decades been used as salvage therapy in some cancers." | 5.32 | Suramin suppresses growth, alkaline-phosphatase and telomerase activity of human osteosarcoma cells in vitro. ( Blahovec, H; Trieb, K, 2003) |
| "The effect of suramin on tumor growth and morphology in two different human osteosarcoma xenografts (L-I OSM and L-II OSM) grown in BALB/cA-nu/nu mice was studied." | 3.68 | Suramin inhibits growth of human osteosarcoma xenografts in nude mice. ( Abdiu, A; Larsson, SE; Smeds, S; Walz, TM; Wasteson, A; Wingren, S, 1991) |
| "Previous studies have shown that suramin reveals specific PDGF binding sites on U-2 OS human osteosarcoma cells." | 3.67 | DNA synthesis in U-2 OS human osteosarcoma cells is independent of PDGF binding to functional cell surface receptors. ( Graves, DT; Richter, MR, 1988) |
| "Suramin has in the last two decades been used as salvage therapy in some cancers." | 1.32 | Suramin suppresses growth, alkaline-phosphatase and telomerase activity of human osteosarcoma cells in vitro. ( Blahovec, H; Trieb, K, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (20.00) | 18.7374 |
| 1990's | 5 (50.00) | 18.2507 |
| 2000's | 3 (30.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Trieb, K | 1 |
| Blahovec, H | 1 |
| Hughes, I | 1 |
| Saito, M | 1 |
| Schlesinger, PH | 1 |
| Ornitz, DM | 1 |
| Buchinger, B | 1 |
| Spitzer, S | 1 |
| Karlic, H | 1 |
| Klaushofer, K | 1 |
| Varga, F | 1 |
| Kloen, P | 1 |
| Jennings, CL | 1 |
| Gebhardt, MC | 1 |
| Springfield, DS | 1 |
| Mankin, HJ | 1 |
| Jorgensen, NR | 1 |
| Geist, ST | 1 |
| Civitelli, R | 1 |
| Steinberg, TH | 1 |
| Benini, S | 1 |
| Baldini, N | 1 |
| Manara, MC | 1 |
| Chano, T | 1 |
| Serra, M | 1 |
| Rizzi, S | 1 |
| Lollini, PL | 1 |
| Picci, P | 1 |
| Scotlandi, K | 1 |
| Walz, TM | 1 |
| Abdiu, A | 1 |
| Wingren, S | 1 |
| Smeds, S | 1 |
| Larsson, SE | 1 |
| Wasteson, A | 1 |
| Pollak, M | 1 |
| Richard, M | 1 |
| Richter, MR | 1 |
| Graves, DT | 2 |
| Owen, AJ | 1 |
| Antoniades, HN | 1 |
10 other studies available for suramin and Osteosarcoma
| Article | Year |
|---|---|
Suramin suppresses growth, alkaline-phosphatase and telomerase activity of human osteosarcoma cells in vitro.
Topics: Alkaline Phosphatase; Antineoplastic Agents; Bone Neoplasms; Cell Division; Humans; Osteosarcoma; Su | 2003 |
Otopetrin 1 activation by purinergic nucleotides regulates intracellular calcium.
Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Signaling; Cell Line; Chlorocebus aethiops; COS Ce | 2007 |
Lysyl oxidase (LOX) mRNA expression and genes of the differentiated osteoblastic phenotype are upregulated in human osteosarcoma cells by suramin.
Topics: Alkaline Phosphatase; Animals; Anticarcinogenic Agents; Cell Differentiation; Cell Line, Tumor; Cell | 2008 |
Suramin inhibits growth and transforming growth factor-beta 1 (TGF-beta 1) binding in osteosarcoma cell lines.
Topics: Bone Neoplasms; Cell Division; DNA, Neoplasm; Dose-Response Relationship, Drug; Humans; Osteosarcoma | 1994 |
ATP- and gap junction-dependent intercellular calcium signaling in osteoblastic cells.
Topics: Adenosine Triphosphate; Animals; Calcium; Cell Line; Connexin 43; Connexins; Cricetinae; Gap Junctio | 1997 |
Redundancy of autocrine loops in human osteosarcoma cells.
Topics: Antineoplastic Agents; Autocrine Communication; Becaplermin; Bone Neoplasms; Drug Resistance, Multip | 1999 |
Suramin inhibits growth of human osteosarcoma xenografts in nude mice.
Topics: Animals; Cell Division; DNA, Neoplasm; Dose-Response Relationship, Drug; Humans; Mice; Mice, Nude; N | 1991 |
Suramin blockade of insulinlike growth factor I-stimulated proliferation of human osteosarcoma cells.
Topics: Affinity Labels; Albumins; Cell Division; Cell Membrane; Humans; Insulin-Like Growth Factor I; Osteo | 1990 |
DNA synthesis in U-2 OS human osteosarcoma cells is independent of PDGF binding to functional cell surface receptors.
Topics: Amino Acids; Cell Line; DNA Replication; Humans; Molecular Weight; Osteosarcoma; Platelet-Derived Gr | 1988 |
Demonstration of receptors for a PDGF-like mitogen on human osteosarcoma cells.
Topics: Binding, Competitive; Cell Line; Epidermal Growth Factor; Humans; Kinetics; Osteosarcoma; Platelet-D | 1985 |