suramin has been researched along with Neuromuscular Blockade in 2 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Neuromuscular Blockade: The intentional interruption of transmission at the NEUROMUSCULAR JUNCTION by external agents, usually neuromuscular blocking agents. It is distinguished from NERVE BLOCK in which nerve conduction (NEURAL CONDUCTION) is interrupted rather than neuromuscular transmission. Neuromuscular blockade is commonly used to produce MUSCLE RELAXATION as an adjunct to anesthesia during surgery and other medical procedures. It is also often used as an experimental manipulation in basic research. It is not strictly speaking anesthesia but is grouped here with anesthetic techniques. The failure of neuromuscular transmission as a result of pathological processes is not included here.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Amongst the suramin analogues in this study, only the NF449 and suramin were able to reverse the blockade effect produced by d-TC on nerve-stimulated muscle contractions." | 7.77 | Study of the reversal effect of NF449 on neuromuscular blockade induced by d-tubocurarine. ( Chen, YH; Hsiao, G; Huang, SS; Hung, YS; Lin, MJ; Su, CC; Su, HH; Su, TR, 2011) |
| "Amongst the suramin analogues in this study, only the NF449 and suramin were able to reverse the blockade effect produced by d-TC on nerve-stimulated muscle contractions." | 3.77 | Study of the reversal effect of NF449 on neuromuscular blockade induced by d-tubocurarine. ( Chen, YH; Hsiao, G; Huang, SS; Hung, YS; Lin, MJ; Su, CC; Su, HH; Su, TR, 2011) |
| "Pretreatment with suramin (0." | 1.30 | Suramin inhibits the toxic effects of presynaptic neurotoxins at the mouse motor nerve terminals. ( Lin, MJ; Lin-Shiau, SY, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Su, TR | 1 |
| Hung, YS | 1 |
| Huang, SS | 1 |
| Su, HH | 1 |
| Su, CC | 1 |
| Hsiao, G | 1 |
| Chen, YH | 1 |
| Lin, MJ | 2 |
| Lin-Shiau, SY | 1 |
2 other studies available for suramin and Neuromuscular Blockade
| Article | Year |
|---|---|
Study of the reversal effect of NF449 on neuromuscular blockade induced by d-tubocurarine.
Topics: Acetylcholine; Animals; Benzenesulfonates; Binding, Competitive; Chickens; Dose-Response Relationshi | 2011 |
Suramin inhibits the toxic effects of presynaptic neurotoxins at the mouse motor nerve terminals.
Topics: Animals; Bungarotoxins; Diaphragm; Evoked Potentials; In Vitro Techniques; Membrane Potentials; Mice | 1999 |