suramin has been researched along with Nervous System Disorders in 5 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We used population pharmacokinetic-parameter estimates and designed a fixed dosing schedule to maintain plasma suramin concentrations between 100 and 300 micrograms/mL and then evaluated its performance." | 2.68 | Development and validation of a pharmacokinetically based fixed dosing scheme for suramin. ( Egorin, MJ; Eisenberger, MA; Reyno, LM; Sinibaldi, VJ; Sridhara, R; Zuhowski, EG, 1995) |
| "Suramin is a promising agent for the treatment of hormone-refractory metastatic prostate cancer." | 2.68 | Phase I study of suramin given by intermittent infusion without adaptive control in patients with advanced cancer. ( Janish, L; Kobayashi, K; Ratain, MJ; Soliven, B; Vogelzang, NJ; Vokes, EE, 1995) |
| "Significant neurologic toxicity can result from therapy with suramin, even when dosing is designed to avoid exposure to plasma concentrations greater than 350 micrograms/mL." | 2.68 | Pharmacologic variables associated with the development of neurologic toxicity in patients treated with suramin. ( Bitton, RJ; Bowden, C; Cooper, MR; Dalakas, MC; Figg, WD; Headlee, D; Myers, CE; Reed, E; Venzon, DJ, 1995) |
| "Suramin sodium is an aromatic polysulfonated compound that was originally introduced as an antiparasitic agent in the 1920s." | 1.28 | A pilot study of suramin in the treatment of metastatic renal cell carcinoma. ( Cooper, MR; Danesi, R; La Rocca, RV; Myers, CE; Stein, CA; Uhrich, M, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Reyno, LM | 1 |
| Egorin, MJ | 1 |
| Eisenberger, MA | 1 |
| Sinibaldi, VJ | 1 |
| Zuhowski, EG | 1 |
| Sridhara, R | 1 |
| Kobayashi, K | 1 |
| Vokes, EE | 1 |
| Vogelzang, NJ | 1 |
| Janish, L | 1 |
| Soliven, B | 1 |
| Ratain, MJ | 1 |
| Bitton, RJ | 1 |
| Figg, WD | 1 |
| Venzon, DJ | 1 |
| Dalakas, MC | 1 |
| Bowden, C | 1 |
| Headlee, D | 1 |
| Reed, E | 1 |
| Myers, CE | 3 |
| Cooper, MR | 3 |
| Lieberman, R | 1 |
| La Rocca, RV | 2 |
| Gernt, PR | 1 |
| Weinberger, MS | 1 |
| Headlee, DJ | 1 |
| Kohler, DR | 1 |
| Goldspiel, BR | 1 |
| Peck, CC | 1 |
| Stein, CA | 1 |
| Danesi, R | 1 |
| Uhrich, M | 1 |
4 trials available for suramin and Nervous System Disorders
| Article | Year |
|---|---|
Development and validation of a pharmacokinetically based fixed dosing scheme for suramin.
Topics: Adult; Aged; Aged, 80 and over; Disease-Free Survival; Drug Administration Schedule; Drug Monitoring | 1995 |
Phase I study of suramin given by intermittent infusion without adaptive control in patients with advanced cancer.
Topics: Adaptation, Physiological; Adult; Aged; Cohort Studies; Drug Administration Schedule; Drug Monitorin | 1995 |
Pharmacologic variables associated with the development of neurologic toxicity in patients treated with suramin.
Topics: Adult; Aged; Aged, 80 and over; Humans; Logistic Models; Male; Melanoma; Middle Aged; Motor Neuron D | 1995 |
Adaptive control with feedback strategies for suramin dosing.
Topics: Adrenal Gland Neoplasms; Antineoplastic Agents; Bayes Theorem; Creatinine; Drug Monitoring; Humans; | 1992 |
1 other study available for suramin and Nervous System Disorders
| Article | Year |
|---|---|
A pilot study of suramin in the treatment of metastatic renal cell carcinoma.
Topics: Adult; Aged; Carcinoma, Renal Cell; Female; Fever; Gastrointestinal Diseases; Hematologic Diseases; | 1991 |