suramin has been researched along with Nerve Degeneration in 3 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, JE | 1 |
| Kwak, SE | 1 |
| Jo, SM | 1 |
| Kang, TC | 1 |
| Fontaine, V | 1 |
| Kinkl, N | 1 |
| Sahel, J | 1 |
| Dreyfus, H | 1 |
| Hicks, D | 1 |
| Russell, JW | 1 |
| Gill, JS | 1 |
| Sorenson, EJ | 1 |
| Schultz, DA | 1 |
| Windebank, AJ | 1 |
3 other studies available for suramin and Nerve Degeneration
| Article | Year |
|---|---|
Blockade of P2X receptor prevents astroglial death in the dentate gyrus following pilocarpine-induced status epilepticus.
Topics: Animals; Antineoplastic Agents; Astrocytes; Cell Death; Cell Shape; Convulsants; Dentate Gyrus; Dise | 2009 |
Survival of purified rat photoreceptors in vitro is stimulated directly by fibroblast growth factor-2.
Topics: Animals; Antineoplastic Agents; Arrestin; Blood Proteins; Cell Survival; Cells, Cultured; Epidermal | 1998 |
Suramin-induced neuropathy in an animal model.
Topics: Animals; Antineoplastic Agents; Axons; Cell Size; Disease Models, Animal; Dose-Response Relationship | 2001 |