suramin has been researched along with Neglected Diseases in 2 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Neglected Diseases: Diseases that are underfunded and have low name recognition but are major burdens in less developed countries. The World Health Organization has designated six tropical infectious diseases as being neglected in industrialized countries that are endemic in many developing countries (HELMINTHIASIS; LEPROSY; LYMPHATIC FILARIASIS; ONCHOCERCIASIS; SCHISTOSOMIASIS; and TRACHOMA).
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kennedy, PGE | 1 |
| Rodgers, J | 1 |
| Sbaraglini, ML | 1 |
| Vanrell, MC | 1 |
| Bellera, CL | 1 |
| Benaim, G | 1 |
| Carrillo, C | 1 |
| Talevi, A | 1 |
| Romano, PS | 1 |
2 reviews available for suramin and Neglected Diseases
| Article | Year |
|---|---|
Clinical and Neuropathogenetic Aspects of Human African Trypanosomiasis.
Topics: Animals; Antiprotozoal Agents; Blood-Brain Barrier; Brain; Delayed Diagnosis; Humans; Incidence; Neg | 2019 |
Neglected Tropical Protozoan Diseases: Drug Repositioning as a Rational Option.
Topics: Antiprotozoal Agents; Chagas Disease; Drug Repositioning; Humans; Leishmaniasis; Neglected Diseases; | 2016 |