suramin has been researched along with Nasopharyngeal Carcinoma in 1 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Nasopharyngeal Carcinoma: A carcinoma that originates in the EPITHELIUM of the NASOPHARYNX and includes four subtypes: keratinizing squamous cell, non-keratinizing, basaloid squamous cell, and PAPILLARY ADENOCARCINOMA. It is most prevalent in Southeast Asian populations and is associated with EPSTEIN-BARR VIRUS INFECTIONS. Somatic mutations associated with this cancer have been identified in NPCR, BAP1, UBAP1, ERBB2, ERBB3, MLL2, PIK3CA, KRAS, NRAS, and ARID1A genes.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Suramin was found to have the potential to induce cell cycle arrest in S-phase CNE-2 cells." | 5.38 | Suramin inhibits the growth of nasopharyngeal carcinoma cells via the downregulation of osteopontin. ( Chen, X; Jiang, S; Li, C; Yang, G; Yue, Y; Zhang, T; Zhang, X, 2012) |
| "Suramin was found to have the potential to induce cell cycle arrest in S-phase CNE-2 cells." | 1.38 | Suramin inhibits the growth of nasopharyngeal carcinoma cells via the downregulation of osteopontin. ( Chen, X; Jiang, S; Li, C; Yang, G; Yue, Y; Zhang, T; Zhang, X, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jiang, S | 1 |
| Chen, X | 1 |
| Li, C | 1 |
| Zhang, X | 1 |
| Zhang, T | 1 |
| Yue, Y | 1 |
| Yang, G | 1 |
1 other study available for suramin and Nasopharyngeal Carcinoma
| Article | Year |
|---|---|
Suramin inhibits the growth of nasopharyngeal carcinoma cells via the downregulation of osteopontin.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma; Cell Line, Tumor; Down-Regulation; Humans; Nasopharynge | 2012 |