suramin has been researched along with Myocardial Ischemia in 2 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Adenosine-enhanced IPC was inhibited by pretreatment with PTX and SPT but not by suramin or RB, whereas ATP-enhanced IPC was inhibited by suramin or RB in combination with PTX pretreatment." | 1.31 | Enhanced IPC by activation of pertussis toxin-sensitive and -insensitive G protein-coupled purinoceptors. ( Imamura, H; Kido, M; Lu, K; Ninomiya, H; Otani, H; Uchiyama, T, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Suadicani, SO | 1 |
| Vink, MJ | 1 |
| Spray, DC | 1 |
| Ninomiya, H | 1 |
| Otani, H | 1 |
| Lu, K | 1 |
| Uchiyama, T | 1 |
| Kido, M | 1 |
| Imamura, H | 1 |
2 other studies available for suramin and Myocardial Ischemia
| Article | Year |
|---|---|
Slow intercellular Ca(2+) signaling in wild-type and Cx43-null neonatal mouse cardiac myocytes.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Antineoplastic Agents; Apyrase; Calcium Signaling | 2000 |
Enhanced IPC by activation of pertussis toxin-sensitive and -insensitive G protein-coupled purinoceptors.
Topics: Adenosine; Adenosine Triphosphate; Animals; Enzyme Inhibitors; Genistein; GTP-Binding Proteins; Indo | 2002 |