suramin has been researched along with Muscular Atrophy in 1 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Muscular Atrophy: Derangement in size and number of muscle fibers occurring with aging, reduction in blood supply, or following immobilization, prolonged weightlessness, malnutrition, and particularly in denervation.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Absolute hypophosphatemia developed in two patients with more prolonged suramin treatment due to Fanconi's syndrome." | 9.07 | Suramin-induced weakness from hypophosphatemia and mitochondrial myopathy. Association of suramin with mitochondrial toxicity in humans. ( Miles, JM; Rago, RP; Spriggs, DR; Sufit, RL; Wilding, G, 1994) |
| " Absolute hypophosphatemia developed in two patients with more prolonged suramin treatment due to Fanconi's syndrome." | 5.07 | Suramin-induced weakness from hypophosphatemia and mitochondrial myopathy. Association of suramin with mitochondrial toxicity in humans. ( Miles, JM; Rago, RP; Spriggs, DR; Sufit, RL; Wilding, G, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rago, RP | 1 |
| Miles, JM | 1 |
| Sufit, RL | 1 |
| Spriggs, DR | 1 |
| Wilding, G | 1 |
1 trial available for suramin and Muscular Atrophy
| Article | Year |
|---|---|
Suramin-induced weakness from hypophosphatemia and mitochondrial myopathy. Association of suramin with mitochondrial toxicity in humans.
Topics: Electron Transport Complex IV; Fanconi Syndrome; Humans; Hypophosphatemia; Male; Mitochondria, Muscl | 1994 |