Compounds > suramin
Page last updated: 2024-11-04

suramin and Muscle Relaxation

suramin has been researched along with Muscle Relaxation in 30 studies

Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.

Muscle Relaxation: That phase of a muscle twitch during which a muscle returns to a resting position.

Research Excerpts

ExcerptRelevanceReference
"The purpose of the present study was to ascertain the role of adenylate (AC) versus guanylate cyclase (GC) signaling pathways in the internal anal sphincter (IAS) smooth muscle relaxation by beta(1)-, beta(2)-, and beta(3)-adrenoceptor (AR) activation by xamoterol, procaterol, and disodium 5-[(2R)-2-(3-chlorophenyl)-2-hydroxy-ethyl]amino)propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316243), respectively."3.72Role of adenylate and guanylate cyclases in beta1-, beta2-, and beta3-adrenoceptor-mediated relaxation of internal anal sphincter smooth muscle. ( De Godoy, M; Li, F; Rattan, S, 2004)

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-19901 (3.33)18.7374
1990's17 (56.67)18.2507
2000's9 (30.00)29.6817
2010's3 (10.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Durnin, L1
Hwang, SJ1
Kurahashi, M1
Drumm, BT1
Ward, SM1
Sasse, KC1
Sanders, KM1
Mutafova-Yambolieva, VN1
Lai, HH1
Smith, CP1
Munoz, A1
Boone, TB1
Szigeti, GP1
Somogyi, GT1
Aronsson, P1
Andersson, M1
Ericsson, T1
Giglio, D1
Montaño, LM1
Cruz-Valderrama, JE1
Figueroa, A1
Flores-Soto, E1
García-Hernández, LM1
Carbajal, V1
Segura, P1
Méndez, C1
Díaz, V1
Barajas-López, C1
De Man, JG1
De Winter, BY1
Seerden, TC1
De Schepper, HU1
Herman, AG1
Pelckmans, PA1
Li, F1
De Godoy, M1
Rattan, S1
Huizinga, JD1
Dixit, D1
Zarate, N1
Hamrouni, AM1
Gudka, N1
Broadley, KJ1
Undi, S2
Benkó, R2
Wolf, M2
Illényi, L2
Horváth, OP2
Antal, A2
Csontos, Z1
Vereczkei, A2
Barthó, L2
Kassai, M1
Cseke, L1
Kelemen, D1
Magyar, K1
Lau, WA1
Ventura, S1
Jiang, Q1
Pennefather, JN1
Ragazzi, E2
Chinellato, A2
Pandolfo, L2
Froldi, G2
Caparrotta, L2
Aliev, G1
Prosdocimi, M1
Fassina, G2
Briejer, MR1
Akkermans, LM1
Meulemans, AL1
Lefebvre, RA1
Schuurkes, JA1
Johnson, CR2
Hourani, SM2
Vials, AJ1
Burnstock, G3
Brizzolara, AL1
Crowe, R1
Piper, AS1
Hollingsworth, M1
Charlton, SJ1
Bültmann, R3
Wittenburg, H1
Pause, B1
Kurz, G1
Nickel, P1
Starke, K3
Dudeck, O1
Otsuguro, K2
Ito, S2
Ohta, T2
Nakazato, Y2
Mutsukado, Y1
Tsuru, H1
Sasa, M1
Kambe, M1
Yamakido, M1
Pinna, C1
Puglisi, L1
Glasgow, I1
Mattar, K1
Krantis, A1
Miasiro, N1
Karaki, H1
Matsuda, Y1
Paiva, AC1
Rae, GA1
Jenkinson, KM1
Reid, JJ1
den Hertog, A1
Nelemans, A1
Van den Akker, J1

Other Studies

30 other studies available for suramin and Muscle Relaxation

ArticleYear
Uridine adenosine tetraphosphate is a novel neurogenic P2Y1 receptor activator in the gut.
    Proceedings of the National Academy of Sciences of the United States of America, 2014, Nov-04, Volume: 111, Issue:44

    Topics: Adenosine Diphosphate; Animals; Antineoplastic Agents; Colon; Deoxyadenine Nucleotides; Dinucleoside

2014
Activation of cholinergic receptors blocks non-adrenergic non-cholinergic contractions in the rat urinary bladder.
    Brain research bulletin, 2008, Dec-16, Volume: 77, Issue:6

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

2008
Assessment and characterization of purinergic contractions and relaxations in the rat urinary bladder.
    Basic & clinical pharmacology & toxicology, 2010, Volume: 107, Issue:1

    Topics: Adenine Nucleotides; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Drug Antagonism; Electr

2010
Characterization of P2Y receptors mediating ATP induced relaxation in guinea pig airway smooth muscle: involvement of prostaglandins and K+ channels.
    Pflugers Archiv : European journal of physiology, 2011, Volume: 462, Issue:4

    Topics: 4-Aminopyridine; Adenine; Adenosine Triphosphate; Animals; Ethylmaleimide; Guinea Pigs; Male; Muscle

2011
Functional evidence that ATP or a related purine is an inhibitory NANC neurotransmitter in the mouse jejunum: study on the identity of P2X and P2Y purinoceptors involved.
    British journal of pharmacology, 2003, Volume: 140, Issue:6

    Topics: Adenosine Triphosphate; Animals; Apamin; Electric Stimulation; Enzyme Inhibitors; In Vitro Technique

2003
Role of adenylate and guanylate cyclases in beta1-, beta2-, and beta3-adrenoceptor-mediated relaxation of internal anal sphincter smooth muscle.
    The Journal of pharmacology and experimental therapeutics, 2004, Volume: 308, Issue:3

    Topics: Adenine; Adenylyl Cyclases; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Blotting

2004
Intrinsic inhibitory innervation of the stomach.
    British journal of pharmacology, 2005, Volume: 146, Issue:1

    Topics: Adenosine Triphosphate; Animals; Apamin; Gastric Fundus; Muscle Relaxation; NG-Nitroarginine Methyl

2005
Investigation of the mechanism for the relaxation of rat duodenum mediated via M1 muscarinic receptors.
    Autonomic & autacoid pharmacology, 2006, Volume: 26, Issue:3

    Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Bicuculline; Dose-Res

2006
Purinergic nerves mediate the non-nitrergic relaxation of the human ileum in response to electrical field stimulation.
    Brain research bulletin, 2006, Dec-11, Volume: 71, Issue:1-3

    Topics: Adenosine Triphosphate; Adrenergic beta-Agonists; Electric Stimulation; Enteric Nervous System; Enzy

2006
P2 purinoceptor antagonists inhibit the non-adrenergic, non-cholinergic relaxation of the human colon in vitro.
    Neuroscience, 2007, Jun-15, Volume: 147, Issue:1

    Topics: Adenosine Triphosphate; Colon, Sigmoid; Drug Interactions; Electric Stimulation; Enzyme Inhibitors;

2007
Endothelin-induced facilitation of sympathetic neurotransmission to the rat vas deferens: effects of suramin.
    European journal of pharmacology, 1995, Jan-05, Volume: 272, Issue:1

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1995
Endothelial nucleotide-mediated aorta relaxation in aged Watanabe heritable hyperlipidemic rabbits.
    Journal of cardiovascular pharmacology, 1995, Volume: 26, Issue:1

    Topics: Acetylcholine; Adenosine Triphosphate; Aging; Animals; Aorta, Thoracic; Arginine; Arteriosclerosis;

1995
5-HT-induced neurogenic relaxations of the guinea-pig proximal colon: investigation into the role of ATP and VIP in addition to nitric oxide.
    Naunyn-Schmiedeberg's archives of pharmacology, 1995, Volume: 351, Issue:2

    Topics: Adenosine Triphosphate; Animals; Apamin; Colon; Female; Guinea Pigs; In Vitro Techniques; Isoprotere

1995
Contractile effects of uridine 5'-triphosphate in the rat duodenum.
    British journal of pharmacology, 1994, Volume: 113, Issue:4

    Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Duodenum; Guanosine Triphosphate; In Vitro Tec

1994
Purine- and nucleotide-mediated relaxation of rabbit thoracic aorta: common and different sites of action.
    The Journal of pharmacy and pharmacology, 1994, Volume: 46, Issue:5

    Topics: Adenosine; Adenosine Diphosphate; Adenosine Triphosphate; Adenosine-5'-(N-ethylcarboxamide); Animals

1994
The effect of suramin on vasodilator responses to ATP and 2-methylthio-ATP in the Sprague-Dawley rat coronary vasculature.
    European journal of pharmacology, 1994, Jan-14, Volume: 251, Issue:2-3

    Topics: Adenosine; Adenosine Triphosphate; Animals; Coronary Vessels; Drug Interactions; In Vitro Techniques

1994
Evidence for the involvement of both ATP and nitric oxide in non-adrenergic, non-cholinergic inhibitory neurotransmission in the rabbit portal vein.
    British journal of pharmacology, 1993, Volume: 109, Issue:3

    Topics: Adenosine Triphosphate; Animals; Arginine; Autonomic Nervous System; Electric Stimulation; Histocyto

1993
ATP and beta,gamma-methylene ATP produce relaxation of guinea-pig isolated trachealis muscle via actions at P1 purinoceptors.
    European journal of pharmacology, 1996, Jun-27, Volume: 307, Issue:2

    Topics: Adenosine Triphosphate; Animals; Carbachol; Female; Guinea Pigs; In Vitro Techniques; Indomethacin;

1996
Responses of the longitudinal muscle and the muscularis mucosae of the rat duodenum to adenine and uracil nucleotides.
    British journal of pharmacology, 1996, Volume: 117, Issue:5

    Topics: Adenosine Triphosphate; Animals; Duodenum; In Vitro Techniques; Male; Muscle Contraction; Muscle Rel

1996
P2-purinoceptor antagonists: III. Blockade of P2-purinoceptor subtypes and ecto-nucleotidases by compounds related to suramin.
    Naunyn-Schmiedeberg's archives of pharmacology, 1996, Volume: 354, Issue:4

    Topics: Adenosine Diphosphate; Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Colon; Guinea Pig

1996
Evaluation of P2-purinoceptor antagonists at two relaxation-mediating P2-purinoceptors in guinea-pig taenia coli.
    Naunyn-Schmiedeberg's archives of pharmacology, 1996, Volume: 353, Issue:4

    Topics: Adrenergic alpha-Agonists; Animals; Carbachol; Colon; Dose-Response Relationship, Drug; Female; Guin

1996
Influence of purines and pyrimidines on circular muscle of the rat proximal stomach.
    European journal of pharmacology, 1996, Dec-12, Volume: 317, Issue:1

    Topics: Adenosine Triphosphate; Animals; Calcium; Female; In Vitro Techniques; Male; Muscle Contraction; Mus

1996
Nonadrenergic, noncholinergic inhibitory innervation in the longitudinal muscle of the rabbit portal vein.
    General pharmacology, 1997, Volume: 29, Issue:5

    Topics: Adenosine Triphosphate; Animals; Autonomic Nervous System; Electric Stimulation; Endothelium, Vascul

1997
ATP and vasoactive intestinal polypeptide relaxant responses in hamster isolated proximal urethra.
    British journal of pharmacology, 1998, Volume: 124, Issue:6

    Topics: Adenosine Triphosphate; Animals; Calcitonin Gene-Related Peptide; Cricetinae; Dinoprostone; Male; Me

1998
Rat gastroduodenal motility in vivo: involvement of NO and ATP in spontaneous motor activity.
    The American journal of physiology, 1998, Volume: 275, Issue:5

    Topics: Adenosine Triphosphate; Animals; Arginine; Carbachol; Duodenum; Gastrointestinal Motility; Male; Mus

1998
Two types of relaxation-mediating P2 receptors in rat gastric circular muscle.
    Japanese journal of pharmacology, 1998, Volume: 78, Issue:2

    Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Ani

1998
Effects of endothelin ET(B) receptor agonists and antagonists on the biphasic response in the ileum.
    European journal of pharmacology, 1999, Mar-19, Volume: 369, Issue:2

    Topics: Animals; Apamin; Dose-Response Relationship, Drug; Drug Interactions; Endothelin Receptor Antagonist

1999
The P(2)-purinoceptor antagonist suramin is a competitive antagonist at vasoactive intestinal peptide receptors in the rat gastric fundus.
    British journal of pharmacology, 2000, Volume: 130, Issue:7

    Topics: Adenosine Triphosphate; Adrenergic beta-Agonists; Animals; Binding, Competitive; Drug Interactions;

2000
Nucleotide-evoked relaxation of rat vas deferens--a possible role for endogenous ATP released upon alpha(1)-adrenoceptor stimulation.
    European journal of pharmacology, 2001, Jun-22, Volume: 422, Issue:1-3

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Apyrase; Dose-Response Relationship, Drug; I

2001
The inhibitory action of suramin on the P2-purinoceptor response in smooth muscle cells of guinea-pig taenia caeci.
    European journal of pharmacology, 1989, Aug-03, Volume: 166, Issue:3

    Topics: Adenosine Triphosphate; Animals; Cecum; Electrophysiology; Female; Guinea Pigs; In Vitro Techniques;

1989