suramin has been researched along with Muscle Contraction in 118 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
Excerpt | Relevance | Reference |
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"Amongst the suramin analogues in this study, only the NF449 and suramin were able to reverse the blockade effect produced by d-TC on nerve-stimulated muscle contractions." | 7.77 | Study of the reversal effect of NF449 on neuromuscular blockade induced by d-tubocurarine. ( Chen, YH; Hsiao, G; Huang, SS; Hung, YS; Lin, MJ; Su, CC; Su, HH; Su, TR, 2011) |
"Amongst the suramin analogues in this study, only the NF449 and suramin were able to reverse the blockade effect produced by d-TC on nerve-stimulated muscle contractions." | 3.77 | Study of the reversal effect of NF449 on neuromuscular blockade induced by d-tubocurarine. ( Chen, YH; Hsiao, G; Huang, SS; Hung, YS; Lin, MJ; Su, CC; Su, HH; Su, TR, 2011) |
" ATP significantly increased the strength of muscle contraction induced by carbachol." | 3.73 | Role of protein kinase C in the effect of ATP on contractile function of the isolated strip from mouse diaphragm. ( Grishin, SN; Teplov, AY; Zefirov, AL; Ziganshin, AU, 2006) |
"Strips from rabbits with colitis induced by 2,4,6-trinitrobenzenesulfonic acid (TNBS) were subjected to electrical field stimulation." | 3.72 | Mechanisms involved in the loss of excitatory post-stimulus responses by inflammation. ( Depoortere, I; Peeters, TL; Thielemans, L; Thijs, T, 2003) |
"OFQ (10(-10) to 10(-6) mol/L) caused circular muscle contractions that were blocked by tetrodotoxin (10(-7) mol/L), suggesting the contractions were nerve mediated." | 3.70 | Orphanin FQ causes contractions via inhibiting purinergic pathway in the rat colon. ( Bagnol, D; Galligan, JJ; Ishiguchi, T; LePard, K; Mizuta, Y; Owyang, C; Schneider, D; Takahashi, T; Watson, SJ, 2000) |
"Suramin was efficient to decrease the lethality in a dose-dependent way." | 1.39 | Neutralization of Apis mellifera bee venom activities by suramin. ( Calil-Elias, S; El-Kik, CZ; Fernandes, FF; Fonseca, TF; Gaban, GA; Martinez, AM; Melo, PA; Oliveira, SD; Silva, CL; Tomaz, MA, 2013) |
" Our results suggest that the association between an antimuscarinic drug and an antagonist of P2X purinoceptors such as suramin might be helpful to reduce the therapeutic dosage of the antimuscarinic drug, along with its side effects." | 1.33 | Altered neurogenic and mechanical responses to acetylcholine, ATP and substance P in detrusor from rat with outlet obstruction. ( Pinna, C; Puglisi, L; Sanvito, P, 2006) |
"Suramin has been found to inhibit transforming growth factor (TGF)-beta1 expression by competitively binding to the growth factor receptor." | 1.32 | Antifibrotic effects of suramin in injured skeletal muscle after laceration. ( Chan, YS; Foster, W; Fu, FH; Horaguchi, T; Huard, J; Li, Y; Somogyi, G, 2003) |
"Verapamil was devoid of any inhibitory action." | 1.31 | Differential effects of drugs interacting with autonomic transmitters on responses of rat vas deferens to field stimulation. ( Boselli, C; Grana, E, 2000) |
"Pretreatment with suramin (0." | 1.30 | Suramin inhibits the toxic effects of presynaptic neurotoxins at the mouse motor nerve terminals. ( Lin, MJ; Lin-Shiau, SY, 1999) |
"Prazosin and suramin were used to suppress non-neural ATP release, and effects of bromoxidine and rauwolscine on the neural release thus isolated were examined." | 1.29 | Neural ATP release and its alpha 2-adrenoceptor-mediated modulation in guinea-pig vas deferens. ( Driessen, B; Starke, K; von Kügelgen, I, 1993) |
" Furthermore, NPY was without effect on the dose-response curve to ATP in resting conditions." | 1.29 | Failure of the putative neuropeptide Y antagonists, benextramine and PYX-2, to inhibit Y2 receptors in rat isolated prostatic vas deferens. ( Corsi, M; Palea, S; Ratti, E; Rimland, JM; Trist, DG, 1995) |
"3." | 1.29 | P2-purinoceptors mediating spasm of the isolated uterus of the non-pregnant guinea-pig. ( Hollingsworth, M; Piper, AS, 1996) |
"Suramin was devoid of agonist activity in the rat vas deferens." | 1.28 | Suramin: a selective inhibitor of purinergic neurotransmission in the rat isolated vas deferens. ( Mallard, N; Marshall, R; Sithers, A; Spriggs, B, 1992) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 2 (1.69) | 18.7374 |
1990's | 62 (52.54) | 18.2507 |
2000's | 38 (32.20) | 29.6817 |
2010's | 14 (11.86) | 24.3611 |
2020's | 2 (1.69) | 2.80 |
Authors | Studies |
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Kawata, R | 1 |
Hotta, Y | 1 |
Maeda, K | 1 |
Kataoka, T | 1 |
Kimura, K | 1 |
Hamaguchi, S | 1 |
Kariya, M | 1 |
Ozaki, AF | 1 |
Namekata, I | 1 |
Tanaka, H | 1 |
El-Kik, CZ | 1 |
Fernandes, FF | 1 |
Tomaz, MA | 1 |
Gaban, GA | 1 |
Fonseca, TF | 1 |
Calil-Elias, S | 1 |
Oliveira, SD | 1 |
Silva, CL | 1 |
Martinez, AM | 1 |
Melo, PA | 1 |
Yuan, W | 1 |
Wang, Z | 2 |
Li, J | 1 |
Li, D | 2 |
Liu, D | 1 |
Bai, G | 1 |
Walsh, MP | 2 |
Gui, Y | 2 |
Zheng, XL | 2 |
Afeli, SA | 1 |
Rovner, ES | 1 |
Petkov, GV | 1 |
Kuruppu, S | 1 |
Chaisakul, J | 1 |
Smith, AI | 1 |
Hodgson, WC | 1 |
Yuan, WS | 1 |
Xu, LJ | 1 |
Liu, MD | 1 |
Wang, YB | 1 |
Martínez-Cutillas, M | 1 |
Gil, V | 1 |
Gallego, D | 1 |
Mañé, N | 1 |
Clavé, P | 1 |
Martín, MT | 1 |
Jiménez, M | 4 |
Ziganshin, AU | 4 |
Khairullin, AE | 1 |
Zobov, VV | 1 |
Ziganshina, LE | 2 |
Gabdrakhmanov, AI | 1 |
Ziganshin, BA | 1 |
Grishin, SN | 4 |
Germinario, E | 1 |
Esposito, A | 1 |
Midrio, M | 1 |
Peron, S | 1 |
Palade, PT | 1 |
Betto, R | 1 |
Danieli-Betto, D | 1 |
Lai, HH | 1 |
Smith, CP | 1 |
Munoz, A | 1 |
Boone, TB | 1 |
Szigeti, GP | 1 |
Somogyi, GT | 1 |
Acheson, A | 1 |
Rayment, S | 1 |
Eames, T | 1 |
Mundey, M | 1 |
Nisar, P | 1 |
Scholefield, J | 1 |
Wilson, VG | 1 |
Munhoz, E | 1 |
De Lima, TC | 1 |
Souccar, C | 1 |
Lapa, AJ | 1 |
Lima-Landman, MT | 1 |
Kato, T | 1 |
Nakamura, E | 1 |
Imaeda, K | 2 |
Suzuki, H | 2 |
Rummery, NM | 1 |
Tripovic, D | 1 |
McLachlan, EM | 1 |
Brock, JA | 1 |
Flores-Soto, E | 1 |
Carbajal, V | 1 |
Reyes-García, J | 1 |
García-Hernández, LM | 1 |
Figueroa, A | 1 |
Checa, M | 1 |
Barajas-López, C | 1 |
Montaño, LM | 1 |
Su, TR | 1 |
Hung, YS | 1 |
Huang, SS | 1 |
Su, HH | 1 |
Su, CC | 1 |
Hsiao, G | 1 |
Chen, YH | 1 |
Lin, MJ | 2 |
Sun, X | 1 |
Li, JJ | 1 |
Gao, J | 1 |
Amobi, NI | 1 |
Guillebaud, J | 1 |
Smith, IC | 1 |
Büyüknacar, HS | 2 |
Eser, N | 1 |
Göçmen, C | 3 |
de Groat, WC | 3 |
Kumcu, EK | 2 |
Ertuğ, PU | 1 |
Onder, S | 2 |
Kamaliev, RR | 2 |
Teplov, AY | 2 |
Depoortere, I | 1 |
Thijs, T | 1 |
Thielemans, L | 1 |
Peeters, TL | 1 |
Chan, YS | 1 |
Li, Y | 1 |
Foster, W | 1 |
Horaguchi, T | 1 |
Somogyi, G | 1 |
Fu, FH | 1 |
Huard, J | 1 |
Matsuyama, H | 1 |
El-Mahmoudy, A | 2 |
Shimizu, Y | 2 |
Takewaki, T | 2 |
Bradley, E | 1 |
Law, A | 1 |
Bell, D | 1 |
Johnson, CD | 1 |
Buljubasich, R | 1 |
Ventura, S | 3 |
Giesselman, B | 1 |
Zefirov, AL | 2 |
Burnstock, G | 3 |
Singirik, E | 1 |
Pinna, C | 1 |
Sanvito, P | 1 |
Puglisi, L | 1 |
Jurkiewicz, NH | 1 |
Caricati-Neto, A | 1 |
Verde, LF | 1 |
Avellar, MC | 1 |
Reuter, HR | 1 |
Jurkiewicz, A | 1 |
Werner, ME | 1 |
Knorn, AM | 2 |
Meredith, AL | 1 |
Aldrich, RW | 1 |
Nelson, MT | 2 |
Shiina, T | 1 |
Khalifa, M | 1 |
Draid, M | 1 |
Kanai, A | 1 |
Roppolo, J | 1 |
Ikeda, Y | 1 |
Zabbarova, I | 1 |
Tai, C | 1 |
Birder, L | 1 |
Griffiths, D | 1 |
de Groat, W | 1 |
Fry, C | 1 |
Ng, YK | 1 |
Wu, HY | 1 |
Giglio, D | 1 |
Aronsson, P | 1 |
Eriksson, L | 1 |
Tobin, G | 1 |
Kennedy, C | 4 |
Tasker, PN | 1 |
Gallacher, G | 1 |
Westfall, TD | 3 |
Thorneloe, KS | 1 |
Doetsch, PE | 1 |
Lashinger, ES | 1 |
Liu, AX | 1 |
Bond, CT | 1 |
Adelman, JP | 1 |
Lau, WA | 2 |
Jiang, Q | 1 |
Pennefather, JN | 2 |
Zagorodnyuk, V | 2 |
Santicioli, P | 1 |
Maggi, CA | 3 |
Giachetti, A | 1 |
Piper, AS | 3 |
Hollingsworth, M | 3 |
Bailey, SJ | 3 |
Hourani, SM | 6 |
Khakh, BS | 2 |
Surprenant, A | 1 |
Humphrey, PP | 2 |
Creed, KE | 1 |
Callahan, SM | 1 |
Ito, Y | 1 |
Bültmann, R | 9 |
Trendelenburg, M | 2 |
Starke, K | 10 |
Michel, A | 1 |
Muramatsu, I | 1 |
Kigoshi, S | 1 |
Oda, Y | 1 |
Driessen, B | 4 |
von Kügelgen, I | 5 |
Elrick, DB | 1 |
Cunnane, TC | 1 |
Kurz, AK | 1 |
Johnson, CR | 2 |
Venkova, K | 2 |
Krier, J | 2 |
Milne, A | 1 |
Karunanithi, S | 1 |
Lavidis, NA | 1 |
Bennett, MR | 1 |
Palea, S | 2 |
Corsi, M | 1 |
Rimland, JM | 1 |
Trist, DG | 1 |
Ratti, E | 1 |
Usune, S | 1 |
Katsuragi, T | 4 |
Furukawa, T | 2 |
Ralevic, V | 1 |
Gonçalves, J | 1 |
Najbar, AT | 1 |
Li, CG | 1 |
Rand, MJ | 1 |
Charlton, SJ | 1 |
Wittenburg, H | 2 |
Pause, B | 1 |
Kurz, G | 1 |
Nickel, P | 3 |
Serio, R | 1 |
Mulè, F | 1 |
Postorino, A | 1 |
Vetri, T | 1 |
Bonvissuto, F | 1 |
Otsuguro, K | 1 |
Ito, S | 1 |
Ohta, T | 1 |
Nakazato, Y | 1 |
Ren, LM | 1 |
Ishizaki, M | 1 |
Iizuka, Y | 1 |
Suzuki-Kusaba, M | 1 |
Kimura, T | 1 |
Satoh, S | 1 |
Lambrecht, G | 3 |
McIntyre, CA | 1 |
Obeid, S | 1 |
Bowes, J | 1 |
Sneddon, P | 4 |
Barthó, L | 1 |
Lénárd, L | 1 |
Tong, YC | 1 |
Hung, YC | 1 |
Shinozuka, K | 1 |
Kunitomo, M | 1 |
Cheng, JT | 1 |
Onaka, U | 1 |
Fujii, K | 1 |
Abe, I | 1 |
Fujishima, M | 1 |
Tagliani, M | 1 |
Candura, SM | 1 |
Di Nucci, A | 1 |
Franceschetti, GP | 1 |
D'Agostino, G | 1 |
Ricotti, P | 1 |
Fiori, E | 1 |
Tonini, M | 1 |
Fernández, E | 3 |
Guo, X | 1 |
Vergara, P | 1 |
McLaren, GJ | 1 |
Burke, KS | 1 |
Buchanan, KJ | 1 |
Hong, SJ | 1 |
Chang, CC | 1 |
Xue, L | 1 |
Yamamoto, Y | 1 |
Venkateswarlu, K | 1 |
Dange, SY | 1 |
Manchanda, R | 1 |
Plujà, L | 2 |
Miasiro, N | 1 |
Karaki, H | 1 |
Matsuda, Y | 1 |
Paiva, AC | 1 |
Rae, GA | 1 |
Tuluc, F | 1 |
Sato, C | 2 |
Tsujioka, Y | 1 |
Lin-Shiau, SY | 1 |
Fukumitsu, A | 1 |
Takano, Y | 1 |
Iki, A | 1 |
Honda, K | 1 |
Saito, R | 1 |
Kamiya, H | 1 |
Todorov, LD | 1 |
Todorova, SM | 1 |
Westfall, DP | 1 |
Ganso, M | 2 |
Bäumert, HG | 1 |
Spatz-Kümbel, G | 1 |
Hildebrandt, C | 2 |
Braun, K | 2 |
Mutschler, E | 1 |
Vizi, ES | 1 |
Nitahara, K | 1 |
Sato, K | 1 |
Sperlágh, B | 1 |
Shahbazian, A | 1 |
Holzer, P | 1 |
Mutafova-Yambolieva, VN | 1 |
Carolan, BM | 1 |
Harden, TK | 1 |
Keef, KD | 1 |
Takahashi, T | 1 |
Bagnol, D | 1 |
Schneider, D | 1 |
Mizuta, Y | 1 |
Ishiguchi, T | 1 |
LePard, K | 1 |
Galligan, JJ | 1 |
Watson, SJ | 1 |
Owyang, C | 1 |
Boselli, C | 2 |
Grana, E | 1 |
Gonzalez, A | 1 |
Sarna, SK | 1 |
Rettinger, J | 1 |
Kassack, M | 1 |
Ullmann, H | 1 |
Schmalzing, G | 1 |
Shen, JZ | 1 |
Zheng, XF | 1 |
Wei, EQ | 1 |
Kwan, CY | 1 |
Pessina, F | 1 |
Matteucci, G | 1 |
Esposito, L | 1 |
Gorelli, B | 1 |
Valoti, M | 1 |
Sgaragli, G | 1 |
Lluel, P | 1 |
Barras, M | 1 |
Govoni, S | 1 |
Formigli, L | 1 |
Francini, F | 1 |
Meacci, E | 1 |
Vassalli, M | 1 |
Nosi, D | 1 |
Quercioli, F | 1 |
Tiribilli, B | 1 |
Bencini, C | 1 |
Piperio, C | 1 |
Bruni, P | 1 |
Orlandini, SZ | 1 |
Mallard, NJ | 1 |
Marshall, RW | 1 |
Sithers, AJ | 1 |
Spriggs, TL | 1 |
Henning, RH | 1 |
Nelemans, A | 1 |
Scaf, AH | 1 |
Van Eekeren, J | 1 |
Agoston, S | 1 |
Den Hertog, A | 1 |
Mallard, N | 1 |
Marshall, R | 1 |
Sithers, A | 1 |
Spriggs, B | 1 |
Nally, JE | 1 |
Muir, TC | 1 |
Bartlet, AL | 1 |
Machaly, M | 1 |
Hickman, D | 1 |
Tokunaga, T | 1 |
Ogawa, S | 1 |
Soejima, O | 1 |
Blakeley, AG | 2 |
Brockbank, JE | 1 |
Kelly, SS | 1 |
Petersen, SA | 1 |
Leff, P | 1 |
Wood, BE | 1 |
O'Connor, SE | 1 |
Chown, JA | 1 |
Dunn, PM | 1 |
1 review available for suramin and Muscle Contraction
Article | Year |
---|---|
Design and pharmacology of selective P2-purinoceptor antagonists.
Topics: Animals; Guinea Pigs; Humans; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Muscle, | 1996 |
117 other studies available for suramin and Muscle Contraction
Article | Year |
---|---|
Effects of High Salt Intake on Detrusor Muscle Contraction in Dahl Salt-Sensitive Rats.
Topics: Animals; Carbachol; Cholinergic Agonists; Dose-Response Relationship, Drug; Electric Stimulation; Is | 2021 |
Contribution of ATP-Mediated Positive Feedback to Sympathetic Nerve-Induced Positive Inotropy in Guinea Pig Ventricular Myocardium.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Feedback, Physiological; Guinea Pigs; Heart | 2021 |
Neutralization of Apis mellifera bee venom activities by suramin.
Topics: Animals; Antivenins; Bee Venoms; Capillary Permeability; Cells, Cultured; Creatine Kinase; Edema; En | 2013 |
Uridine adenosine tetraphosphate induces contraction of circular and longitudinal gastric smooth muscle by distinct signaling pathways.
Topics: Adenosine Triphosphate; Amides; Animals; Dinucleoside Phosphates; Male; Muscle Contraction; Muscle, | 2013 |
BRL37344, a β3-adrenergic receptor agonist, decreases nerve-evoked contractions in human detrusor smooth muscle isolated strips: role of BK channels.
Topics: Adenosine Triphosphate; Adrenergic beta-3 Receptor Agonists; Aged; Atropine; Dose-Response Relations | 2013 |
Inhibition of presynaptic neurotoxins in taipan venom by suramin.
Topics: Animals; Antivenins; Arachidonic Acid; Chickens; Elapid Venoms; Elapidae; In Vitro Techniques; Lysop | 2014 |
[The different contraction between rat gastric longitudinal and circular smooth muscle induced by extracellular nucleotides].
Topics: Adenosine Triphosphate; Animals; Dinucleoside Phosphates; Indomethacin; Muscle Contraction; Muscle, | 2014 |
α,β-meATP mimics the effects of the purinergic neurotransmitter in the human and rat colon.
Topics: Adenosine Triphosphate; Aged; Animals; Apamin; Colon; Deoxyadenine Nucleotides; Electric Stimulation | 2014 |
Effects of ATP and adenosine on contraction amplitude of rat soleus muscle at different temperatures.
Topics: Adenosine; Adenosine Triphosphate; Analysis of Variance; Animals; Carbachol; Cholinergic Agonists; E | 2017 |
High-frequency fatigue of skeletal muscle: role of extracellular Ca(2+).
Topics: Animals; Calcimycin; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Signaling; Cell Me | 2008 |
Activation of cholinergic receptors blocks non-adrenergic non-cholinergic contractions in the rat urinary bladder.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2008 |
Investigation of the role of adrenergic and non-nitrergic, non-adrenergic neurotransmission in the sheep isolated internal anal sphincter.
Topics: Adenosine Diphosphate; Adrenergic alpha-Antagonists; Anal Canal; Animals; Anti-Arrhythmia Agents; Ap | 2009 |
Allosteric interaction of the anticholinergic drug [N-(4-phenyl)-phenacyl-l-hyoscyamine] (Phenthonium) with nicotinic receptors of post-ganglionic sympathetic neurons of the rat vas deferens.
Topics: Adenosine Triphosphate; Allosteric Regulation; Animals; Atropine; Atropine Derivatives; Cholinergic | 2009 |
Modulation of the activity of two pacemakers by transmural nerve stimulation in circular smooth muscle preparations isolated from the rat proximal colon.
Topics: Animals; Apamin; Atropine; Biological Clocks; Capsaicin; Colon; Electric Stimulation; Enzyme Inhibit | 2009 |
Sympathetic vasoconstriction is potentiated in arteries caudal but not rostral to a spinal cord transection in rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Arteries; Clonidine; Data Interpre | 2010 |
In airways ATP refills sarcoplasmic reticulum via P2X smooth muscle receptors and induces contraction through P2Y epithelial receptors.
Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Signaling; Guinea Pigs; Indomethacin; Male; Muscle | 2011 |
Study of the reversal effect of NF449 on neuromuscular blockade induced by d-tubocurarine.
Topics: Acetylcholine; Animals; Benzenesulfonates; Binding, Competitive; Chickens; Dose-Response Relationshi | 2011 |
Uridine adenosine tetraphosphate induces contraction of airway smooth muscle.
Topics: Animals; Bronchi; Calcium; Calcium Channels, L-Type; Dinucleoside Phosphates; Male; Muscle Contracti | 2011 |
Perspective on the role of P2X-purinoceptor activation in human vas deferens contractility.
Topics: 4-Aminopyridine; Adenosine Triphosphate; Amides; Apamin; Calcium Channel Agonists; Calcium Channels, | 2012 |
Prejunctional facilitatory effect of a thiol-alkylating agent N-Ethylmaleimide on neurogenic contractions in rat prostate smooth muscle.
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Atropine; Calcium Channel Blockers; Electric Stimu | 2012 |
Opposite effect of ATP on contraction force of tonic and phasic skeletal muscles in frogs.
Topics: Adenosine; Adenosine Triphosphate; Animals; Calcium; Muscle Contraction; Muscle Fibers, Skeletal; Mu | 2011 |
Mechanisms involved in the loss of excitatory post-stimulus responses by inflammation.
Topics: Adenosine Triphosphate; Animals; Colitis; Cyclooxygenase Inhibitors; Electric Stimulation; Female; I | 2003 |
Antifibrotic effects of suramin in injured skeletal muscle after laceration.
Topics: 3T3 Cells; Actins; Animals; Blotting, Western; Fibroblasts; Fibrosis; Injections; Intracellular Memb | 2003 |
Nitrergic prejunctional inhibition of purinergic neuromuscular transmission in the hamster proximal colon.
Topics: Adenosine Triphosphate; Animals; Colon; Cricetinae; Electric Stimulation; Enzyme Inhibitors; Male; M | 2003 |
Effects of varying impulse number on cotransmitter contributions to sympathetic vasoconstriction in rat tail artery.
Topics: Adenosine Triphosphate; Adrenergic alpha-Antagonists; Animals; Arginine; Arteries; Electric Stimulat | 2003 |
Adenosine 5'-triphosphate and noradrenaline are excitatory cotransmitters to the fibromuscular stroma of the guinea pig prostate gland.
Topics: Actins; Adenosine Diphosphate; Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Atropine; | 2004 |
Effect of neocuproine, a copper(i) chelator, on rat bladder function.
Topics: Adenosine Triphosphate; Animals; Chelating Agents; Copper; Electric Stimulation; Female; In Vitro Te | 2005 |
The influence of hypothermia on P2 receptor-mediated responses of frog skeletal muscle.
Topics: Action Potentials; Adenosine; Adenosine Triphosphate; Analysis of Variance; Animals; Dose-Response R | 2005 |
Neocuproine, a copper (I) chelator, potentiates purinergic component of vas deferens contractions elicited by electrical field stimulation.
Topics: Adenosine Triphosphate; Animals; Chelating Agents; Electric Stimulation; In Vitro Techniques; Male; | 2005 |
Altered neurogenic and mechanical responses to acetylcholine, ATP and substance P in detrusor from rat with outlet obstruction.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Atropine; Cholinergic Agonists; Cyclooxygenase Inhib | 2006 |
Sympathetic neurotransmission in the rat testicular capsule: functional characterization and identification of mRNA encoding alpha1-adrenoceptor subtypes.
Topics: Acetyl-CoA C-Acyltransferase; Adenosine Triphosphate; Adrenergic alpha-Antagonists; Adrenergic Uptak | 2006 |
Frequency encoding of cholinergic- and purinergic-mediated signaling to mouse urinary bladder smooth muscle: modulation by BK channels.
Topics: Adenosine Triphosphate; Animals; Atropine; Cholinergic Agents; Electric Stimulation; Female; Immunoh | 2007 |
Purinergic control of the quail rectum: modulation of adenosine 5'-triphosphate-mediated contraction with acetylcholine.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Atropine; Cholinesterase Inhibitors; Coturnix; Elect | 2007 |
Origin of spontaneous activity in neonatal and adult rat bladders and its enhancement by stretch and muscarinic agonists.
Topics: Animals; Animals, Newborn; Atropine; Calcium Signaling; Carbachol; Diacetyl; Electric Stimulation; E | 2007 |
Role of protein kinase C in the effect of ATP on contractile function of the isolated strip from mouse diaphragm.
Topics: Adenosine; Adenosine Triphosphate; Alkaloids; Animals; Benzophenanthridines; Carbachol; Cardiotonic | 2006 |
Smooth muscle and neural mechanisms contributing to the downregulation of neonatal rat spontaneous bladder contractions during postnatal development.
Topics: Aging; Animals; Atropine; Down-Regulation; Muscarinic Antagonists; Muscle Contraction; Muscle, Smoot | 2007 |
In vitro characterization of parasympathetic and sympathetic responses in cyclophosphamide-induced cystitis in the rat.
Topics: Adenosine Triphosphate; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Cyclopho | 2007 |
Identification of atropine- and P2X1 receptor antagonist-resistant, neurogenic contractions of the urinary bladder.
Topics: Animals; Atropine; Drug Resistance; Guinea Pigs; Male; Muscle Contraction; Purinergic P2 Receptor An | 2007 |
Small-conductance, Ca(2+) -activated K+ channel 2 is the key functional component of SK channels in mouse urinary bladder.
Topics: Animals; Apamin; beta-Galactosidase; Data Interpretation, Statistical; Electric Stimulation; Genes, | 2008 |
Endothelin-induced facilitation of sympathetic neurotransmission to the rat vas deferens: effects of suramin.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1995 |
Evidence that tachykinin NK1 and NK2 receptors mediate non-adrenergic non-cholinergic excitation and contraction in the circular muscle of guinea-pig duodenum.
Topics: Action Potentials; Adenosine Diphosphate; Animals; Apamin; Arginine; Atropine; Dose-Response Relatio | 1995 |
The purinoceptors of the guinea-pig isolated taenia caeci.
Topics: Adenosine; Animals; Cecum; Female; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscl | 1995 |
Effects of suramin on contractions of the guinea-pig vas deferens induced by analogues of adenosine 5'-triphosphate.
Topics: Adenosine Triphosphate; Animals; Electric Stimulation; Guinea Pigs; Male; Muscle Contraction; Muscle | 1995 |
A study on P2X purinoceptors mediating the electrophysiological and contractile effects of purine nucleotides in rat vas deferens.
Topics: Adenosine Triphosphate; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Electric Conduct | 1995 |
Excitatory neurotransmission in the mammalian bladder and the effects of suramin.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Guinea Pigs; Humans; Macaca mulatta; Muscle Cont | 1994 |
Blockade of P2X-purinoceptors by trypan blue in rat vas deferens.
Topics: Adenosine Triphosphate; Animals; Electric Stimulation; In Vitro Techniques; Male; Muscle Contraction | 1994 |
Estimates of antagonist affinities at P2X purinoceptors in rat vas deferens.
Topics: Adenosine Triphosphate; Animals; Binding, Competitive; Congo Red; Glutathione Transferase; Male; Mus | 1994 |
Evidence for sympathetic, purinergic transmission in the iris dilator muscle of the rabbit.
Topics: Adenosine Triphosphate; Adrenergic alpha-Antagonists; Animals; Electric Stimulation; Female; Guaneth | 1994 |
The fade of the purinergic neurogenic contraction of the guinea-pig vas deferens: analysis of possible mechanisms.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Calcium Channels; Electric Stimulation; Guinea P | 1994 |
Release of ATP in rat vas deferens: origin and role of calcium.
Topics: Adenosine Triphosphate; Adrenergic alpha-Agonists; Animals; Calcium; Electric Stimulation; Guinea Pi | 1994 |
Contractile effects of uridine 5'-triphosphate in the rat duodenum.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Duodenum; Guanosine Triphosphate; In Vitro Tec | 1994 |
Neural ATP release and its alpha 2-adrenoceptor-mediated modulation in guinea-pig vas deferens.
Topics: Adenosine Triphosphate; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagon | 1993 |
Stimulation of lumbar sympathetic nerves evokes contractions of cat colon circular muscle mediated by ATP and noradrenaline.
Topics: Adenosine Triphosphate; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Azides; | 1993 |
Contractions mediated by alpha 1-adrenoceptors and P2-purinoceptors in a cat colon circular muscle.
Topics: Adenosine Triphosphate; Animals; Cats; Colon; Female; In Vitro Techniques; Male; Muscle Contraction; | 1994 |
Effect of yohimbine on the contractile response of the mouse vas deferens to short, low frequency trains of nerve impulses.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Electric Stimulation; Electrodes; In Vitro Techniq | 1994 |
Differential effects of suramin on P2-purinoceptors mediating contraction of the guinea-pig vas deferens and urinary bladder.
Topics: Adenosine Triphosphate; Animals; Guinea Pigs; In Vitro Techniques; Magnesium; Male; Muscle Contracti | 1994 |
Evans blue blocks P2X-purinoceptors in rat vas deferens.
Topics: Adenosine Triphosphate; Animals; Evans Blue; In Vitro Techniques; Male; Muscle Contraction; Muscle, | 1993 |
Failure of the putative neuropeptide Y antagonists, benextramine and PYX-2, to inhibit Y2 receptors in rat isolated prostatic vas deferens.
Topics: Adenosine Triphosphate; Adrenergic alpha-Antagonists; Animals; Cystamine; In Vitro Techniques; Male; | 1995 |
Effects of PPADS and suramin on contractions and cytoplasmic Ca2+ changes evoked by AP4A, ATP and alpha, beta-methylene ATP in guinea-pig urinary bladder.
Topics: Adenosine Triphosphate; Calcium; Calcium Channel Blockers; Cytoplasm; Dinucleoside Phosphates; In Vi | 1996 |
P2-purinoceptors mediating spasm of the isolated uterus of the non-pregnant guinea-pig.
Topics: Adenosine Triphosphate; Animals; Female; Guinea Pigs; Indomethacin; Muscle Contraction; Muscle, Smoo | 1996 |
Relative contribution of P2U- and P2Y-purinoceptors to endothelium-dependent vasodilatation in the golden hamster isolated mesenteric arterial bed.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Cricetinae; Endothelium, Vascular; Male; Mes | 1996 |
Opposite modulation of noradrenaline and ATP release in guinea-pig vas deferens through prejunctional beta-adrenoceptors: evidence for the beta 2 subtype.
Topics: Adenosine Triphosphate; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Adrenergic beta-Anta | 1996 |
Evidence for two distinct P2-purinoceptors subserving contraction of the rat anococcygeus smooth muscle.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Dose-Response Relationship, Drug; Male; Musc | 1996 |
ATP and beta,gamma-methylene ATP produce relaxation of guinea-pig isolated trachealis muscle via actions at P1 purinoceptors.
Topics: Adenosine Triphosphate; Animals; Carbachol; Female; Guinea Pigs; In Vitro Techniques; Indomethacin; | 1996 |
Responses of the longitudinal muscle and the muscularis mucosae of the rat duodenum to adenine and uracil nucleotides.
Topics: Adenosine Triphosphate; Animals; Duodenum; In Vitro Techniques; Male; Muscle Contraction; Muscle Rel | 1996 |
P2-purinoceptor antagonists: III. Blockade of P2-purinoceptor subtypes and ecto-nucleotidases by compounds related to suramin.
Topics: Adenosine Diphosphate; Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Colon; Guinea Pig | 1996 |
Apamin-sensitive and -insensitive components of inhibitory junction potentials in rat caecum: role of nitric oxide.
Topics: Analysis of Variance; Animals; Apamin; Cecum; Electric Stimulation; Enzyme Inhibitors; Gap Junctions | 1996 |
Influence of purines and pyrimidines on circular muscle of the rat proximal stomach.
Topics: Adenosine Triphosphate; Animals; Calcium; Female; In Vitro Techniques; Male; Muscle Contraction; Mus | 1996 |
Prominent sympathetic purinergic vasoconstriction in the rabbit splenic artery: potentiation by 2,2'-pyridylisatogen tosylate.
Topics: Adenosine Triphosphate; Adrenergic Agents; Animals; Electric Stimulation; Guanethidine; In Vitro Tec | 1997 |
Nonadrenergic contractile response of guinea pig portal vein to electrical field stimulation mimics response to UTP but not to ATP.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Adenosine Triphosphate; Adrenergic alpha-Antagonis | 1997 |
The interaction of diadenosine polyphosphates with P2x-receptors in the guinea-pig isolated vas deferens.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Analysis of Variance; Animals; Dinucleoside Phosp | 1997 |
Evidence for the involvement of P2-purinoceptors in the cholinergic contraction of the guinea-pig ileum.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Electric Stimulation; Guinea Pigs; Ileum; In Vitro T | 1997 |
Evidence of adenosine 5'-triphosphate release from nerve and P2x-purinoceptor mediated contraction during electrical stimulation of rat urinary bladder smooth muscle.
Topics: Adenosine Triphosphate; Animals; Electric Stimulation; Muscle Contraction; Muscle, Smooth; Neurotran | 1997 |
Enhancement by exogenous and locally generated angiotensin II of purinergic neurotransmission via angiotensin type 1 receptor in the guinea-pig isolated mesenteric artery.
Topics: Adenosine Triphosphate; Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Ani | 1997 |
A re-appraisal of the nature of the atropine-resistant contraction to electrical field stimulation in the human isolated detrusor muscle.
Topics: Adenosine Triphosphate; Aged; Aged, 80 and over; Atropine; Electric Stimulation; Female; Humans; In | 1997 |
Pharmacological evidence for the existence of multiple P2 receptors in the circular muscle of guinea-pig colon.
Topics: Adenosine Diphosphate; Animals; Apamin; Autonomic Nervous System; Colon; Electric Stimulation; Guine | 1998 |
Evidence supporting a role for ATP as non-adrenergic non-cholinergic inhibitory transmitter in the porcine ileum.
Topics: Adenosine Triphosphate; Animals; Apamin; Electrophysiology; Female; Ileum; Male; Muscle Contraction; | 1998 |
Evidence that ATP acts at two sites to evoke contraction in the rat isolated tail artery.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Arteries; Enzyme Inhibitors; Male; Muscl | 1998 |
Evaluation of intrinsic modulation of synaptic transmission by ATP in mouse fast twitch muscle.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Diaphragm; Drug Antagonism; In Vitro Techniques; Mem | 1998 |
Effects of suramin on electrical and mechanical activities in antrum smooth muscle of the guinea-pig stomach.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Atropine; Electromyography; Guinea Pigs; Male; Muscl | 1998 |
Pharmacology of neurotransmission to the smooth muscle of the rat and the guinea-pig prostate glands.
Topics: Animals; Cholinesterase Inhibitors; Electric Stimulation; Electromyography; Guinea Pigs; In Vitro Te | 1998 |
Effects of heptanol on the neurogenic and myogenic contractions of the guinea-pig vas deferens.
Topics: Adenosine Triphosphate; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Electric S | 1999 |
Neural modulation of the cyclic electrical and mechanical activity in the rat colonic circular muscle: putative role of ATP and NO.
Topics: Adenosine Triphosphate; Animals; Apamin; Colon; Electric Stimulation; Male; Membrane Potentials; Mus | 1999 |
Effects of endothelin ET(B) receptor agonists and antagonists on the biphasic response in the ileum.
Topics: Animals; Apamin; Dose-Response Relationship, Drug; Drug Interactions; Endothelin Receptor Antagonist | 1999 |
Concomitant blockade of P2X-receptors and ecto-nucleotidases by P2-receptor antagonists: functional consequences in rat vas deferens.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Adenosine Triphosphatases; Adenosine Triphosphate; | 1999 |
Cross desensitizations on contractions by P2-agonists of guinea pig ileum.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Dose-Response Relationship, Drug; Guinea Pig | 1999 |
Suramin inhibits the toxic effects of presynaptic neurotoxins at the mouse motor nerve terminals.
Topics: Animals; Bungarotoxins; Diaphragm; Evoked Potentials; In Vitro Techniques; Membrane Potentials; Mice | 1999 |
Endogenous ATP released by electrical field stimulation causes contraction via P2x- and P2y-purinoceptors in the isolated tail artery of rats.
Topics: Adenosine Triphosphate; Animals; Arteries; Electric Stimulation; Endothelium, Vascular; In Vitro Tec | 1999 |
Electrical and mechanical effects of vasoactive intestinal peptide and pituitary adenylate cyclase-activating peptide in the rat colon involve different mechanisms.
Topics: Animals; Apamin; Colon; Electric Stimulation; In Vitro Techniques; Male; Membrane Potentials; Muscle | 2000 |
The effect of P2 receptor antagonists and ATPase inhibition on sympathetic purinergic neurotransmission in the guinea-pig isolated vas deferens.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Chromatography, High Pressure Liquid; El | 2000 |
The novel heteromeric bivalent ligand SB9 potently antagonizes P2Y(1) receptor-mediated responses.
Topics: 5'-Nucleotidase; Adenosine Triphosphate; Animals; Female; Guinea Pigs; Ileum; In Vitro Techniques; K | 2000 |
Stimulation-dependent release, breakdown, and action of endogenous ATP in mouse hemidiaphragm preparation: the possible role of ATP in neuromuscular transmission.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Chromatography, High Pressure Liquid; Di | 2000 |
Differences in circular muscle contraction and peristaltic motor inhibition caused by tachykinin NK1 receptor agonists in the guinea-pig small intestine.
Topics: Adenosine Triphosphate; Animals; Enzyme Inhibitors; Female; Guinea Pigs; Intestine, Small; Male; Mot | 2000 |
Multiple P2Y receptors mediate contraction in guinea pig mesenteric vein.
Topics: Adenine Nucleotides; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Guinea Pigs; In Vitro T | 2000 |
Orphanin FQ causes contractions via inhibiting purinergic pathway in the rat colon.
Topics: Animals; Apamin; Colon; In Situ Hybridization; In Vitro Techniques; Male; Muscle Contraction; Muscle | 2000 |
Differential effects of drugs interacting with autonomic transmitters on responses of rat vas deferens to field stimulation.
Topics: Adrenergic alpha-Antagonists; Animals; Calcium Channel Blockers; Drug Interactions; Electric Stimula | 2000 |
Neural regulation of in vitro giant contractions in the rat colon.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2001 |
NF449: a subnanomolar potency antagonist at recombinant rat P2X1 receptors.
Topics: Animals; Benzenesulfonates; Guinea Pigs; Ileum; Male; Muscle Contraction; Muscle, Smooth; Purinergic | 2001 |
Evidence against inhibition of sarcoplasmic reticulum Ca2+-pump as mechanism of H2O2-induced contraction of rat aorta.
Topics: Animals; Aorta, Thoracic; Boron Compounds; Ca(2+) Mg(2+)-ATPase; Endothelium, Vascular; Hydrogen Per | 2001 |
Protection of intrinsic nerves of guinea-pig detrusor strips against anoxia/glucopenia and reperfusion injury by taurine.
Topics: Aminoethylphosphonic Acid; Animals; Atropine; Electric Stimulation; Evoked Potentials; Glucose; Guin | 2000 |
Cholinergic and purinergic contribution to the micturition reflex in conscious rats with long-term bladder outlet obstruction.
Topics: Animals; Atropine; Cholinergic Fibers; Chronic Disease; Drug Combinations; Electric Stimulation; Fem | 2002 |
Effect of in vivo and in vitro ethanol on adrenergic and purinergic responses of the bisected rat vas deferens to low and high frequency pulses.
Topics: Adenosine Triphosphate; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Central Ne | 2001 |
Sphingosine 1-phosphate induces Ca2+ transients and cytoskeletal rearrangement in C2C12 myoblastic cells.
Topics: Aniline Compounds; Animals; Caffeine; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; C | 2002 |
Separation of putative alpha 1A- and alpha 1B-adrenoceptor mediated components in the tension response of the rat vas deferens to electrical field stimulation.
Topics: Animals; Clonidine; Electric Stimulation; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smo | 1992 |
Suramin reverses non-depolarizing neuromuscular blockade in rat diaphragm.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Diaphragm; Drug Interactions; Male; Muscle Contraction | 1992 |
Suramin: a selective inhibitor of purinergic neurotransmission in the rat isolated vas deferens.
Topics: Adenosine Triphosphate; Animals; Electric Stimulation; In Vitro Techniques; Male; Muscle Contraction | 1992 |
The electrical and mechanical responses of the rabbit saphenous artery to nerve stimulation and drugs.
Topics: Adenosine Triphosphate; Adrenergic alpha-Antagonists; Animals; Arteries; Dioxanes; Electric Stimulat | 1992 |
Contractile responses of chicken rectum to stimulation of Remak's nerve or purinoceptors: effect of suramin.
Topics: Adenosine Triphosphate; Animals; Chickens; Drug Interactions; Electric Stimulation; Muscle Contracti | 1992 |
Regional variation in purinergic and adrenergic responses in isolated vas deferens of rat, rabbit and guinea-pig.
Topics: Adenosine Triphosphate; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Epididymis; | 1992 |
Characterization of the P1-purinoceptors mediating contraction of the rat colon muscularis mucosae.
Topics: Adenosine; Adenosine Triphosphate; Animals; Colon; In Vitro Techniques; Male; Muscle Contraction; Mu | 1992 |
Existence of ATP-evoked ATP release system in smooth muscles.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Bethanechol; Bethanechol Compounds; Firefly Luciferi | 1991 |
Contraction-mediating alpha 2-adrenoceptors in the mouse vas deferens.
Topics: Adenosine Triphosphate; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Dioxanes; Drug | 1991 |
Effects of suramin on the concentration--response relationship of alpha, beta-methylene ATP on the mouse vas deferens.
Topics: Adenosine Triphosphate; Animals; Female; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Musc | 1991 |
Suramin is a slowly-equilibrating but competitive antagonist at P2x-receptors in the rabbit isolated ear artery.
Topics: Adenosine Triphosphate; Animals; Arteries; Binding, Competitive; In Vitro Techniques; Kinetics; Male | 1990 |
Interaction of adenine nucleotides, UTP and suramin in mouse vas deferens: suramin-sensitive and suramin-insensitive components in the contractile effect of ATP.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; In Vitro Techniques; Male; Mice; Muscle Contra | 1990 |
The effects of some possible inhibitors of ectonucleotidases on the breakdown and pharmacological effects of ATP in the guinea-pig urinary bladder.
Topics: Adenosine Triphosphate; Animals; Dinitrofluorobenzene; Electric Stimulation; Ethacrynic Acid; Ethylm | 1989 |
Suramin: a reversible P2-purinoceptor antagonist in the mouse vas deferens.
Topics: Adenosine Diphosphate; Animals; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Muscle Contract | 1988 |