Page last updated: 2024-11-04

suramin and Metastase

suramin has been researched along with Metastase in 22 studies

Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.

Research Excerpts

ExcerptRelevanceReference
"These results indicate that suramin is inactive in patients with metastatic colorectal cancer pretreated with fluoropyrimidines."9.08Suramin in patients with metastatic colorectal cancer pretreated with fluoropyrimidine-based chemotherapy. A phase II study. ( Brunetti, I; Cianci, C; Conte, PF; Danesi, R; Del Tacca, M; Falcone, A; Pfanner, E, 1995)
" This study was to explore the inhibitory effect of angiogenesis inhibitor Suramin in combination with cisplatin (DDP) on the growth and lung metastasis of lung adenocarcinoma LA795 cell xenografts in mice."7.73[Effects of suramin in combination with cisplatin on growth and metastasis of lung adenocarcinoma xenografts in mice]. ( He, JB; Ou, LW; Wang, XH; Zhang, P, 2006)
"Suramin-resistant DC-3F/SU 1,000 Chinese hamster fibrosarcoma cells were obtained by continuous exposure of parental DC-3F cells to increasing concentrations of suramin (1 mg/ml final concentration)."7.69Development and characterization of suramin-resistant Chinese hamster fibrosarcoma cells: drug-dependent formation of multicellular spheroids and a greatly enhanced metastatic potential. ( Larsen, AK; Lelièvre, S, 1994)
" We hypothesized that suramin at non-cytotoxic doses in combination with weekly paclitaxel would be well tolerated and demonstrate anti-tumor activity."6.77Phase I/II trial of non-cytotoxic suramin in combination with weekly paclitaxel in metastatic breast cancer treated with prior taxanes. ( Au, JL; Berger, M; Brenner, L; Chen, L; Grever, M; Jensen, RR; Lustberg, MB; Mrozek, E; Pant, S; Ramaswamy, B; Ruppert, AS; Shapiro, CL; Shen, T; Shiels, D; Wei, Y; Wientjes, MG, 2012)
"These results indicate that suramin is inactive in patients with metastatic colorectal cancer pretreated with fluoropyrimidines."5.08Suramin in patients with metastatic colorectal cancer pretreated with fluoropyrimidine-based chemotherapy. A phase II study. ( Brunetti, I; Cianci, C; Conte, PF; Danesi, R; Del Tacca, M; Falcone, A; Pfanner, E, 1995)
" This study was to explore the inhibitory effect of angiogenesis inhibitor Suramin in combination with cisplatin (DDP) on the growth and lung metastasis of lung adenocarcinoma LA795 cell xenografts in mice."3.73[Effects of suramin in combination with cisplatin on growth and metastasis of lung adenocarcinoma xenografts in mice]. ( He, JB; Ou, LW; Wang, XH; Zhang, P, 2006)
"Suramin-resistant DC-3F/SU 1,000 Chinese hamster fibrosarcoma cells were obtained by continuous exposure of parental DC-3F cells to increasing concentrations of suramin (1 mg/ml final concentration)."3.69Development and characterization of suramin-resistant Chinese hamster fibrosarcoma cells: drug-dependent formation of multicellular spheroids and a greatly enhanced metastatic potential. ( Larsen, AK; Lelièvre, S, 1994)
" We hypothesized that suramin at non-cytotoxic doses in combination with weekly paclitaxel would be well tolerated and demonstrate anti-tumor activity."2.77Phase I/II trial of non-cytotoxic suramin in combination with weekly paclitaxel in metastatic breast cancer treated with prior taxanes. ( Au, JL; Berger, M; Brenner, L; Chen, L; Grever, M; Jensen, RR; Lustberg, MB; Mrozek, E; Pant, S; Ramaswamy, B; Ruppert, AS; Shapiro, CL; Shen, T; Shiels, D; Wei, Y; Wientjes, MG, 2012)
" The suramin dosing nomogram used in phase I and II portions of the trial yielded the desired plasma level of 10-50 micromol/L from 4."2.73Phase I/II trial of 5-fluorouracil and a noncytotoxic dose level of suramin in patients with metastatic renal cell carcinoma. ( Au, JJ; Bukowski, RM; Cooney, MM; Dreicer, R; Elson, P; Ganapathi, R; George, S; Mekhail, T; Rini, BI; Roman, S; Shen, T; Wientjes, GM, 2008)
"Suramin was administered by intravenous infusions over 1 hour."2.69Phase II trial of suramin in patients with metastatic renal cell carcinoma. ( Dreicer, R; See, WA; Smith, DC; Williams, RD, 1999)
"Using this dosing schedule, suramin has limited activity against hormone-refractory metastatic prostate cancer."2.68Suramin in hormone-refractory metastatic prostate cancer: a drug with limited efficacy. ( Belldegrun, A; deKernion, J; Graves, MC; Landaw, EM; McBride, JH; Mendoza, EF; Mondino, B; Rosen, PJ; Turcillo, P, 1996)
"Metastatic prostate cancer is a leading cause of cancer-related death in men."2.40Treatment options in androgen-independent prostate cancer. ( Lara, PN; Meyers, FJ, 1999)
" STATEMENT OF SIGNIFICANCE: The doxorubicin-loaded glycol chitosan-suramin nanoparticle (GCS-SM/DOX) is novel in the following aspects: SM acts as not only a gelator for the first time in the preparation of the nanoparticle but also an active pharmaceutical agent in the dosage form."1.51Repurposing suramin for the treatment of breast cancer lung metastasis with glycol chitosan-based nanoparticles. ( Cheng, B; Gao, F; Maissy, E; Xu, P, 2019)
"Exposure of 1E8 and 2B4 prostate cancer cells to ATP resulted in p38 activation in a concentration- and time-dependent manner."1.31[Activation of p38 and c-Jun NH2-terminal kinase mitogen-activated protein kinases in human prostate carcinoma cell lines with different metastatic potentials]. ( Fang, W; He, C; Heng, W; Li, H; Wu, B; You, J; Zheng, J, 2001)
"Micrometastases were identified in bone and liver 1 day after inoculation and grew to form established metastatic foci in all embryos."1.30A chick embryo model for metastatic human prostate cancer. ( Endo, Y; Imao, T; Kobayashi, T; Koshida, K; Namiki, M; Sasaki, T; Uchibayashi, T, 1998)
"A new therapeutic strategy for treating metastasis in hepatocellular carcinoma (HCC) has entailed the use of antiangiogenic agents such as suramin, BB-94 (Batimastat), TNP-470, and carboxyamido-triazole (CAI, a synthetic inhibitor of non-excitable calcium channels that reversibly inhibits angiogenesis)."1.30Effect of antiangiogenic agents on experimental animal models of hepatocellular carcinoma. ( Bu, W; Li, XM; Qin, LX; Tang, ZY; Xia, JL, 1999)
"Suramin has long been used in the treatment of onchocerciasis and trypanosomiasis."1.29[Cutaneous drug reaction caused by suramin in 4 patients with metastatic prostate cancer]. ( Dieckmann, KP; Gollnick, H; Handke, A; Tebbe, B; Wichterich, K, 1994)
"In an experimental murine metastasis model host pretreatment protocol (HPP) was tested to abrogate lung colonization of tumor cells."1.28Experimental metastasis inhibition by pretreatment of the host. ( Ladányi, A; Lapis, K; Paku, S; Pápay, J; Szende, B; Timár, J, 1990)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's15 (68.18)18.2507
2000's4 (18.18)29.6817
2010's3 (13.64)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cheng, B1
Gao, F1
Maissy, E1
Xu, P1
Singla, AK1
Bondareva, A1
Jirik, FR1
George, S1
Dreicer, R2
Au, JJ1
Shen, T2
Rini, BI1
Roman, S1
Cooney, MM1
Mekhail, T1
Elson, P1
Wientjes, GM1
Ganapathi, R1
Bukowski, RM1
Lustberg, MB1
Pant, S1
Ruppert, AS1
Wei, Y1
Chen, L1
Brenner, L1
Shiels, D1
Jensen, RR1
Berger, M1
Mrozek, E1
Ramaswamy, B1
Grever, M2
Au, JL2
Wientjes, MG2
Shapiro, CL1
Villalona-Calero, MA1
Otterson, GA1
Kanter, S1
Young, D1
Murgo, AJ1
Fischer, B1
DeHoff, C1
Chen, D1
Yeh, TK1
Song, S1
Zhang, P1
He, JB1
Ou, LW1
Wang, XH1
Lelièvre, S2
Larsen, AK2
Falcone, A1
Pfanner, E1
Cianci, C1
Danesi, R1
Brunetti, I1
Del Tacca, M1
Conte, PF1
Marutsuka, K1
Hasui, Y1
Asada, Y1
Naito, S1
Osada, Y1
Sumiyoshi, A1
Wichterich, K1
Tebbe, B1
Handke, A1
Dieckmann, KP1
Gollnick, H1
Tisdale, JF1
Figg, WD1
Reed, E1
McCall, NA1
Alkins, BR1
Horne, MK1
Rosen, PJ1
Mendoza, EF1
Landaw, EM1
Mondino, B1
Graves, MC1
McBride, JH1
Turcillo, P1
deKernion, J1
Belldegrun, A1
Panvichian, R1
Pienta, KJ1
Konety, BR1
Getzenberg, RH1
Kobayashi, T1
Koshida, K1
Endo, Y1
Imao, T1
Uchibayashi, T1
Sasaki, T1
Namiki, M1
Lawrence, JB1
Conover, CA1
Haddad, TC1
Ingle, JN1
Reid, JM1
Ames, MM1
Suman, VJ1
Marks, RS1
Erlichman, C1
Hartmann, LC1
Lara, PN1
Meyers, FJ1
Qin, LX1
Tang, ZY1
Li, XM1
Bu, W1
Xia, JL1
Smith, DC1
Williams, RD1
See, WA1
Li, H1
Fang, W1
He, C1
You, J1
Heng, W1
Zheng, J1
Wu, B1
Lapis, K1
Timár, J1
Pápay, J1
Paku, S1
Szende, B1
Ladányi, A1

Reviews

3 reviews available for suramin and Metastase

ArticleYear
The treatment of hormone refractory prostate cancer.
    Comprehensive therapy, 1996, Volume: 22, Issue:2

    Topics: Androgen Antagonists; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Estramu

1996
Novel therapies for advanced prostate cancer.
    Seminars in urologic oncology, 1997, Volume: 15, Issue:1

    Topics: Animals; Antineoplastic Agents; Bombesin; Diet; Enzyme Inhibitors; Epoprostenol; Genetic Therapy; Hu

1997
Treatment options in androgen-independent prostate cancer.
    Cancer investigation, 1999, Volume: 17, Issue:2

    Topics: Adenocarcinoma; Androgen Antagonists; Androgens; Antibodies, Monoclonal; Antineoplastic Agents; Anti

1999

Trials

8 trials available for suramin and Metastase

ArticleYear
Phase I/II trial of 5-fluorouracil and a noncytotoxic dose level of suramin in patients with metastatic renal cell carcinoma.
    Clinical genitourinary cancer, 2008, Volume: 6, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Drug Administrat

2008
Phase I/II trial of non-cytotoxic suramin in combination with weekly paclitaxel in metastatic breast cancer treated with prior taxanes.
    Cancer chemotherapy and pharmacology, 2012, Volume: 70, Issue:1

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Disease-Free Survival

2012
Phase I study of low-dose suramin as a chemosensitizer in patients with advanced non-small cell lung cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2003, Aug-15, Volume: 9, Issue:9

    Topics: Adult; Aged; Antineoplastic Agents; Area Under Curve; Carboplatin; Carcinoma, Non-Small-Cell Lung; D

2003
Suramin in patients with metastatic colorectal cancer pretreated with fluoropyrimidine-based chemotherapy. A phase II study.
    Cancer, 1995, Jan-15, Volume: 75, Issue:2

    Topics: Adult; Aged; Colorectal Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Neo

1995
Severe thrombocytopenia in patients treated with suramin: evidence for an immune mechanism in one.
    American journal of hematology, 1996, Volume: 51, Issue:2

    Topics: Antineoplastic Agents; Humans; Immunoglobulin G; Male; Middle Aged; Neoplasm Metastasis; Platelet Ag

1996
Suramin in hormone-refractory metastatic prostate cancer: a drug with limited efficacy.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1996, Volume: 14, Issue:5

    Topics: Adenocarcinoma; Aged; Aged, 80 and over; Ambulatory Care; Half-Life; Humans; Male; Middle Aged; Neop

1996
Evaluation of continuous infusion suramin in metastatic breast cancer: impact on plasma levels of insulin-like growth factors (IGFs) and IGF-binding proteins.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1997, Volume: 3, Issue:10

    Topics: Adult; Aged; Antineoplastic Agents; Biomarkers, Tumor; Breast Neoplasms; Female; Humans; Hydrocortis

1997
Phase II trial of suramin in patients with metastatic renal cell carcinoma.
    Investigational new drugs, 1999, Volume: 17, Issue:2

    Topics: Adult; Aged; Carcinoma, Renal Cell; Drug Administration Schedule; Female; Humans; Infusions, Intrave

1999

Other Studies

11 other studies available for suramin and Metastase

ArticleYear
Repurposing suramin for the treatment of breast cancer lung metastasis with glycol chitosan-based nanoparticles.
    Acta biomaterialia, 2019, 01-15, Volume: 84

    Topics: Animals; Cell Line, Tumor; Chitosan; Doxorubicin; Female; Human Umbilical Vein Endothelial Cells; Hu

2019
Combined treatment with paclitaxel and suramin prevents the development of metastasis by inhibiting metastatic colonization of circulating tumor cells.
    Clinical & experimental metastasis, 2014, Volume: 31, Issue:6

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Breast Neoplasms; Cell Lin

2014
[Effects of suramin in combination with cisplatin on growth and metastasis of lung adenocarcinoma xenografts in mice].
    Ai zheng = Aizheng = Chinese journal of cancer, 2006, Volume: 25, Issue:4

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cisplatin; Drug Synergi

2006
[Acquisition of resistance to suramin in the cells of fibrosarcoma in Chinese hamsters accompanied by morphologic modification and increased metastatic capacity].
    Bulletin du cancer, 1994, Volume: 81, Issue:10

    Topics: Animals; Cricetinae; Cricetulus; Drug Resistance; Fibrosarcoma; Neoplasm Metastasis; Neoplasms, Expe

1994
Effects of suramin on metastatic ability, proliferation, and production of urokinase-type plasminogen activator and plasminogen activator inhibitor type 2 in human renal cell carcinoma cell line SN12C-PM6.
    Clinical & experimental metastasis, 1995, Volume: 13, Issue:2

    Topics: Animals; Carcinoma, Renal Cell; Cell Division; Kidney Neoplasms; Male; Mice; Mice, Inbred BALB C; Ne

1995
Development and characterization of suramin-resistant Chinese hamster fibrosarcoma cells: drug-dependent formation of multicellular spheroids and a greatly enhanced metastatic potential.
    Cancer research, 1994, Aug-01, Volume: 54, Issue:15

    Topics: Animals; Cell Adhesion; Cell Count; Cell Division; Cricetinae; Cricetulus; Drug Resistance; Fibrosar

1994
[Cutaneous drug reaction caused by suramin in 4 patients with metastatic prostate cancer].
    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1994, Volume: 45, Issue:2

    Topics: Aged; Biopsy; Drug Eruptions; Drug Therapy, Combination; Humans; Infusions, Intravenous; Male; Middl

1994
A chick embryo model for metastatic human prostate cancer.
    European urology, 1998, Volume: 34, Issue:2

    Topics: Animals; Antineoplastic Agents; Bone and Bones; Cell Division; Cell Transplantation; Chick Embryo; C

1998
Effect of antiangiogenic agents on experimental animal models of hepatocellular carcinoma.
    Annals of the Academy of Medicine, Singapore, 1999, Volume: 28, Issue:1

    Topics: Animals; Antineoplastic Agents; Cell Division; Cyclohexanes; Liver Neoplasms, Experimental; Mice; Mi

1999
[Activation of p38 and c-Jun NH2-terminal kinase mitogen-activated protein kinases in human prostate carcinoma cell lines with different metastatic potentials].
    Zhonghua bing li xue za zhi = Chinese journal of pathology, 2001, Volume: 30, Issue:3

    Topics: Adenosine Triphosphate; Cell Line, Tumor; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases;

2001
Experimental metastasis inhibition by pretreatment of the host.
    Archiv fur Geschwulstforschung, 1990, Volume: 60, Issue:2

    Topics: Animals; Epoprostenol; Glycosaminoglycans; Lentinan; Mice; Mice, Inbred C57BL; Neoplasm Metastasis;

1990