Page last updated: 2024-11-04

suramin and Mesothelioma

suramin has been researched along with Mesothelioma in 5 studies

Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.

Mesothelioma: A tumor derived from mesothelial tissue (peritoneum, pleura, pericardium). It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. (Dorland, 27th ed)

Research Excerpts

ExcerptRelevanceReference
" The antitumor effectiveness of cisplatin, paclitaxel, and suramin as single agents and in combination was evaluated in vivo against four lines of human pleural malignant mesothelioma xenografts in athymic nude mice, including one epithelial type and three fibrosarcomatous."7.70Effectiveness of cisplatin, paclitaxel, and suramin against human malignant mesothelioma xenografts in athymic nude mice. ( Chahinian, AP; Gluck, H; Holland, JF; Mandeli, JP; Naim, H; Teirstein, AS, 1998)
"Suramin treatment inhibited in vivo growth in the REN intraperitoneal model shown grossly by necropsy of same day deaths comparing treatment and control animals."5.32Suramin inhibits the growth of malignant mesothelioma in vitro, and in vivo, in murine flank and intraperitoneal models. ( Cook, JW; Kaiser, LR; Singhal, S; Smythe, WR; Sterman, DH, 2003)
" The antitumor effectiveness of cisplatin, paclitaxel, and suramin as single agents and in combination was evaluated in vivo against four lines of human pleural malignant mesothelioma xenografts in athymic nude mice, including one epithelial type and three fibrosarcomatous."3.70Effectiveness of cisplatin, paclitaxel, and suramin against human malignant mesothelioma xenografts in athymic nude mice. ( Chahinian, AP; Gluck, H; Holland, JF; Mandeli, JP; Naim, H; Teirstein, AS, 1998)
" Regular pharmacokinetic sampling of plasma and ascites fluid was carried out."2.69Feasibility and pharmacokinetics of intraperitoneal suramin in advanced malignancy. ( Baars, JP; Beijnen, JH; Dubbelman, R; Moolenaar, WH; Rodenhuis, S; Westermann, AM, 2000)
"Suramin treatment inhibited in vivo growth in the REN intraperitoneal model shown grossly by necropsy of same day deaths comparing treatment and control animals."1.32Suramin inhibits the growth of malignant mesothelioma in vitro, and in vivo, in murine flank and intraperitoneal models. ( Cook, JW; Kaiser, LR; Singhal, S; Smythe, WR; Sterman, DH, 2003)
"Fumagillin can also inhibit cancer cell proliferation, implying that MetAP2 may play a quite complex role in tumor progression."1.31Methionine aminopeptidase-2 regulates human mesothelioma cell survival: role of Bcl-2 expression and telomerase activity. ( Catalano, A; Procopio, A; Robuffo, I; Romano, M; Strizzi, L, 2001)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (40.00)18.2507
2000's3 (60.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cook, JW1
Sterman, DH1
Singhal, S1
Smythe, WR1
Kaiser, LR1
Westermann, AM2
Dubbelman, R2
Moolenaar, WH2
Beijnen, J1
Rodenhuis, S2
Chahinian, AP1
Mandeli, JP1
Gluck, H1
Naim, H1
Teirstein, AS1
Holland, JF1
Baars, JP1
Beijnen, JH1
Catalano, A1
Romano, M1
Robuffo, I1
Strizzi, L1
Procopio, A1

Trials

1 trial available for suramin and Mesothelioma

ArticleYear
Feasibility and pharmacokinetics of intraperitoneal suramin in advanced malignancy.
    Cancer chemotherapy and pharmacology, 2000, Volume: 46, Issue:1

    Topics: Adult; Antineoplastic Agents; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cholangiocarcinoma; Dru

2000

Other Studies

4 other studies available for suramin and Mesothelioma

ArticleYear
Suramin inhibits the growth of malignant mesothelioma in vitro, and in vivo, in murine flank and intraperitoneal models.
    Lung cancer (Amsterdam, Netherlands), 2003, Volume: 42, Issue:3

    Topics: Animals; Antineoplastic Agents; Cell Division; Cell Line, Tumor; Dose-Response Relationship, Drug; H

2003
Successful intraperitoneal suramin treatment of peritoneal mesothelioma.
    Annals of oncology : official journal of the European Society for Medical Oncology, 1997, Volume: 8, Issue:8

    Topics: Adult; Antineoplastic Agents; Follow-Up Studies; Humans; Male; Mesothelioma; Peritoneal Neoplasms; S

1997
Effectiveness of cisplatin, paclitaxel, and suramin against human malignant mesothelioma xenografts in athymic nude mice.
    Journal of surgical oncology, 1998, Volume: 67, Issue:2

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Administration Schedule; Fe

1998
Methionine aminopeptidase-2 regulates human mesothelioma cell survival: role of Bcl-2 expression and telomerase activity.
    The American journal of pathology, 2001, Volume: 159, Issue:2

    Topics: Amino Acid Chloromethyl Ketones; Aminopeptidases; Angiogenesis Inhibitors; Apoptosis; Caspase 3; Cas

2001