suramin has been researched along with Mesothelioma in 5 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Mesothelioma: A tumor derived from mesothelial tissue (peritoneum, pleura, pericardium). It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " The antitumor effectiveness of cisplatin, paclitaxel, and suramin as single agents and in combination was evaluated in vivo against four lines of human pleural malignant mesothelioma xenografts in athymic nude mice, including one epithelial type and three fibrosarcomatous." | 7.70 | Effectiveness of cisplatin, paclitaxel, and suramin against human malignant mesothelioma xenografts in athymic nude mice. ( Chahinian, AP; Gluck, H; Holland, JF; Mandeli, JP; Naim, H; Teirstein, AS, 1998) |
| "Suramin treatment inhibited in vivo growth in the REN intraperitoneal model shown grossly by necropsy of same day deaths comparing treatment and control animals." | 5.32 | Suramin inhibits the growth of malignant mesothelioma in vitro, and in vivo, in murine flank and intraperitoneal models. ( Cook, JW; Kaiser, LR; Singhal, S; Smythe, WR; Sterman, DH, 2003) |
| " The antitumor effectiveness of cisplatin, paclitaxel, and suramin as single agents and in combination was evaluated in vivo against four lines of human pleural malignant mesothelioma xenografts in athymic nude mice, including one epithelial type and three fibrosarcomatous." | 3.70 | Effectiveness of cisplatin, paclitaxel, and suramin against human malignant mesothelioma xenografts in athymic nude mice. ( Chahinian, AP; Gluck, H; Holland, JF; Mandeli, JP; Naim, H; Teirstein, AS, 1998) |
| " Regular pharmacokinetic sampling of plasma and ascites fluid was carried out." | 2.69 | Feasibility and pharmacokinetics of intraperitoneal suramin in advanced malignancy. ( Baars, JP; Beijnen, JH; Dubbelman, R; Moolenaar, WH; Rodenhuis, S; Westermann, AM, 2000) |
| "Suramin treatment inhibited in vivo growth in the REN intraperitoneal model shown grossly by necropsy of same day deaths comparing treatment and control animals." | 1.32 | Suramin inhibits the growth of malignant mesothelioma in vitro, and in vivo, in murine flank and intraperitoneal models. ( Cook, JW; Kaiser, LR; Singhal, S; Smythe, WR; Sterman, DH, 2003) |
| "Fumagillin can also inhibit cancer cell proliferation, implying that MetAP2 may play a quite complex role in tumor progression." | 1.31 | Methionine aminopeptidase-2 regulates human mesothelioma cell survival: role of Bcl-2 expression and telomerase activity. ( Catalano, A; Procopio, A; Robuffo, I; Romano, M; Strizzi, L, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cook, JW | 1 |
| Sterman, DH | 1 |
| Singhal, S | 1 |
| Smythe, WR | 1 |
| Kaiser, LR | 1 |
| Westermann, AM | 2 |
| Dubbelman, R | 2 |
| Moolenaar, WH | 2 |
| Beijnen, J | 1 |
| Rodenhuis, S | 2 |
| Chahinian, AP | 1 |
| Mandeli, JP | 1 |
| Gluck, H | 1 |
| Naim, H | 1 |
| Teirstein, AS | 1 |
| Holland, JF | 1 |
| Baars, JP | 1 |
| Beijnen, JH | 1 |
| Catalano, A | 1 |
| Romano, M | 1 |
| Robuffo, I | 1 |
| Strizzi, L | 1 |
| Procopio, A | 1 |
1 trial available for suramin and Mesothelioma
| Article | Year |
|---|---|
Feasibility and pharmacokinetics of intraperitoneal suramin in advanced malignancy.
Topics: Adult; Antineoplastic Agents; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cholangiocarcinoma; Dru | 2000 |
4 other studies available for suramin and Mesothelioma
| Article | Year |
|---|---|
Suramin inhibits the growth of malignant mesothelioma in vitro, and in vivo, in murine flank and intraperitoneal models.
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Line, Tumor; Dose-Response Relationship, Drug; H | 2003 |
Successful intraperitoneal suramin treatment of peritoneal mesothelioma.
Topics: Adult; Antineoplastic Agents; Follow-Up Studies; Humans; Male; Mesothelioma; Peritoneal Neoplasms; S | 1997 |
Effectiveness of cisplatin, paclitaxel, and suramin against human malignant mesothelioma xenografts in athymic nude mice.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Administration Schedule; Fe | 1998 |
Methionine aminopeptidase-2 regulates human mesothelioma cell survival: role of Bcl-2 expression and telomerase activity.
Topics: Amino Acid Chloromethyl Ketones; Aminopeptidases; Angiogenesis Inhibitors; Apoptosis; Caspase 3; Cas | 2001 |