suramin has been researched along with Meningioma in 3 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Meningioma: A relatively common neoplasm of the CENTRAL NERVOUS SYSTEM that arises from arachnoidal cells. The majority are well differentiated vascular tumors which grow slowly and have a low potential to be invasive, although malignant subtypes occur. Meningiomas have a predilection to arise from the parasagittal region, cerebral convexity, sphenoidal ridge, olfactory groove, and SPINAL CANAL. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2056-7)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The growth of human cerebral meningiomas depends on various growth factors, including epidermal growth factor (EGF), transforming growth factor (TGF)-alpha and TGF-beta, platelet-derived growth factor (PDGF)-BB, insulin-like growth factor (IGF)-I and IGF-II, and acidic and basic fibroblast growth factors." | 7.69 | Inhibition of proliferation of human cerebral meningioma cells by suramin: effects on cell growth, cell cycle phases, extracellular growth factors, and PDGF-BB autocrine growth loop. ( Adams, EF; Bickel, A; Fahlbusch, R; Gauer, S; Hren, J; Kiesewetter, F; Schrell, UM, 1995) |
| " We studied the effects of suramin, a nonspecific growth factor antagonist, on epidermal growth factor (EGF) binding to cell surface receptors in surgically excised human meningiomas, using quantitative receptor autoradiographic methods with radioluminography." | 7.68 | Biphasic effects of suramin on 125I-epidermal growth factor binding to human meningiomas. ( Himeno, A; Khalid, H; Kitagawa, N; Niwa, M; Shibata, S; Taniyama, K; Tsutsumi, K; Yamaga, S, 1993) |
| "The growth of human cerebral meningiomas depends on various growth factors, including epidermal growth factor (EGF), transforming growth factor (TGF)-alpha and TGF-beta, platelet-derived growth factor (PDGF)-BB, insulin-like growth factor (IGF)-I and IGF-II, and acidic and basic fibroblast growth factors." | 3.69 | Inhibition of proliferation of human cerebral meningioma cells by suramin: effects on cell growth, cell cycle phases, extracellular growth factors, and PDGF-BB autocrine growth loop. ( Adams, EF; Bickel, A; Fahlbusch, R; Gauer, S; Hren, J; Kiesewetter, F; Schrell, UM, 1995) |
| " We studied the effects of suramin, a nonspecific growth factor antagonist, on epidermal growth factor (EGF) binding to cell surface receptors in surgically excised human meningiomas, using quantitative receptor autoradiographic methods with radioluminography." | 3.68 | Biphasic effects of suramin on 125I-epidermal growth factor binding to human meningiomas. ( Himeno, A; Khalid, H; Kitagawa, N; Niwa, M; Shibata, S; Taniyama, K; Tsutsumi, K; Yamaga, S, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schrell, UM | 1 |
| Gauer, S | 1 |
| Kiesewetter, F | 1 |
| Bickel, A | 1 |
| Hren, J | 1 |
| Adams, EF | 1 |
| Fahlbusch, R | 1 |
| Tsutsumi, K | 2 |
| Kitagawa, N | 2 |
| Niwa, M | 2 |
| Himeno, A | 2 |
| Taniyama, K | 2 |
| Shibata, S | 2 |
| Yamaga, S | 1 |
| Khalid, H | 1 |
3 other studies available for suramin and Meningioma
| Article | Year |
|---|---|
Inhibition of proliferation of human cerebral meningioma cells by suramin: effects on cell growth, cell cycle phases, extracellular growth factors, and PDGF-BB autocrine growth loop.
Topics: Blotting, Western; Brain Neoplasms; Cell Cycle; Cell Division; DNA; Dose-Response Relationship, Drug | 1995 |
Effect of suramin on 125I-insulin-like growth factor-I binding to human meningiomas and on proliferation of meningioma cells.
Topics: Aged; Cell Division; DNA, Neoplasm; Female; Humans; Insulin-Like Growth Factor I; Iodine Radioisotop | 1994 |
Biphasic effects of suramin on 125I-epidermal growth factor binding to human meningiomas.
Topics: Aged; Autoradiography; Epidermal Growth Factor; ErbB Receptors; Female; Humans; Iodine Radioisotopes | 1993 |