suramin has been researched along with Meningeal Neoplasms in 2 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Meningeal Neoplasms: Benign and malignant neoplastic processes that arise from or secondarily involve the meningeal coverings of the brain and spinal cord.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We studied the effects of suramin, a nonspecific growth factor antagonist, on epidermal growth factor (EGF) binding to cell surface receptors in surgically excised human meningiomas, using quantitative receptor autoradiographic methods with radioluminography." | 7.68 | Biphasic effects of suramin on 125I-epidermal growth factor binding to human meningiomas. ( Himeno, A; Khalid, H; Kitagawa, N; Niwa, M; Shibata, S; Taniyama, K; Tsutsumi, K; Yamaga, S, 1993) |
| " We studied the effects of suramin, a nonspecific growth factor antagonist, on epidermal growth factor (EGF) binding to cell surface receptors in surgically excised human meningiomas, using quantitative receptor autoradiographic methods with radioluminography." | 3.68 | Biphasic effects of suramin on 125I-epidermal growth factor binding to human meningiomas. ( Himeno, A; Khalid, H; Kitagawa, N; Niwa, M; Shibata, S; Taniyama, K; Tsutsumi, K; Yamaga, S, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tsutsumi, K | 2 |
| Kitagawa, N | 2 |
| Niwa, M | 2 |
| Himeno, A | 2 |
| Taniyama, K | 2 |
| Shibata, S | 2 |
| Yamaga, S | 1 |
| Khalid, H | 1 |
2 other studies available for suramin and Meningeal Neoplasms
| Article | Year |
|---|---|
Effect of suramin on 125I-insulin-like growth factor-I binding to human meningiomas and on proliferation of meningioma cells.
Topics: Aged; Cell Division; DNA, Neoplasm; Female; Humans; Insulin-Like Growth Factor I; Iodine Radioisotop | 1994 |
Biphasic effects of suramin on 125I-epidermal growth factor binding to human meningiomas.
Topics: Aged; Autoradiography; Epidermal Growth Factor; ErbB Receptors; Female; Humans; Iodine Radioisotopes | 1993 |