suramin has been researched along with Malaria in 9 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Malaria: A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study, a new semi-synthetic berberine analogue, 5,6-didehydro-8,8-diethyl-13-oxodihydroberberine chloride (1), showed nanomolar level potency against in vitro models of leishmaniasis, malaria, and trypanosomiasis as well as activity in an in vivo visceral leishmaniasis model." | 3.77 | Potent antiprotozoal activity of a novel semi-synthetic berberine derivative. ( Anklin, C; Bahar, M; Deng, Y; Doskotch, RW; Drew, ME; Gil, RR; He, S; Kinghorn, AD; Navarro-Vázquez, A; Pandharkar, T; Werbovetz, KA; Zhu, X, 2011) |
| "We present a case of East-African trypanosomiasis (EAT) in a 56-year-old Dutch woman returning from holiday in Tanzania and Kenya." | 1.48 | A case of delayed diagnosis of East-African trypanosomiasis in a Dutch traveller. ( Hanssen, JLJ; Scheper, H; van Lieshout, L; Visser, LG; Wijsman, CA, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (44.44) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bahar, M | 1 |
| Deng, Y | 1 |
| Zhu, X | 1 |
| He, S | 1 |
| Pandharkar, T | 1 |
| Drew, ME | 1 |
| Navarro-Vázquez, A | 1 |
| Anklin, C | 1 |
| Gil, RR | 1 |
| Doskotch, RW | 1 |
| Werbovetz, KA | 1 |
| Kinghorn, AD | 1 |
| Wijsman, CA | 1 |
| Hanssen, JLJ | 1 |
| Scheper, H | 1 |
| Visser, LG | 1 |
| van Lieshout, L | 1 |
| TELLA, A | 1 |
| Niederau, C | 1 |
| Günther, B | 1 |
| Erkenbrecht, J | 1 |
| Strohmeyer, G | 1 |
| Moore, AC | 1 |
| Ryan, ET | 1 |
| Waldron, MA | 1 |
| Recht, K | 1 |
| Pfürtner-Bloos, I | 1 |
| Gross, R | 1 |
| Takada, S | 1 |
| Woo, P | 1 |
| Soltys, MA | 1 |
| Klein, P | 1 |
9 other studies available for suramin and Malaria
| Article | Year |
|---|---|
Potent antiprotozoal activity of a novel semi-synthetic berberine derivative.
Topics: Animals; Antiprotozoal Agents; Berberine; Chlorocebus aethiops; Disease Models, Animal; Inhibitory C | 2011 |
A case of delayed diagnosis of East-African trypanosomiasis in a Dutch traveller.
Topics: Animals; Delayed Diagnosis; Diagnosis, Differential; Female; Humans; Kenya; Malaria; Middle Aged; Ne | 2018 |
CHEMOTHERAPY OF TROPICAL DISEASES.
Topics: Amebiasis; Amebicides; Anti-Bacterial Agents; Antimalarials; Antimony; Arsenicals; Chagas Disease; C | 1964 |
[Fever after travel to the tropics in Africa: the etiology is not always malaria].
Topics: Adult; Democratic Republic of the Congo; Diagnosis, Differential; Fever of Unknown Origin; Humans; M | 1994 |
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 20-2002. A 37-year-old man with fever, hepatosplenomegaly, and a cutaneous foot lesion after a trip to Africa.
Topics: Adult; Africa; Animals; Anthrax; Blood; Cerebrospinal Fluid; Diagnosis, Differential; Erythema; Feve | 2002 |
[Imported East-African trypanosomiasis (sleeping sickness)].
Topics: Botswana; Diagnosis, Differential; Germany, West; Humans; Malaria; Male; Middle Aged; Suramin; Trypa | 1977 |
[Drugs used against protozoan infections in man].
Topics: Amebiasis; Aminoquinolines; Antiprotozoal Agents; Humans; Malaria; Metronidazole; Pneumonia, Pneumoc | 1990 |
The effect of suramin on blood and tissue forms of Trypanosoma brucei and Trypanosoma rhodesiense.
Topics: Animals; Liver; Malaria; Mice; Rabbits; Recurrence; Spleen; Suramin; Time Factors; Trypanosoma; Tryp | 1971 |
[On the ideological history of the early period of chemotherapy].
Topics: Animals; Arsphenamine; Birds; Drug Therapy; History, 20th Century; Humans; Malaria; Malaria, Avian; | 1966 |