suramin has been researched along with Lymphopenia in 1 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Lymphopenia: Reduction in the number of lymphocytes.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Three cohorts of patients with advanced prostate cancer that progressed despite castrate levels of testosterone received oral hydrocortisone plus suramin administered in the following manners: (1) a loading dose of suramin followed by a continuous infusion using an adaptive control program (cohort A); (2) an intermittent schedule using a simplified adaptive control schedule (cohort B); and (3) an empiric dosing regimen (cohort C)." | 2.68 | Suramin and hydrocortisone: determining drug efficacy in androgen-independent prostate cancer. ( Cohen, L; Curley, T; Dnistrian, A; Kelly, WK; Leibertz, C; Mazumdar, M; Pfister, D; Scher, HI; Schwartz, M; Vlamis, V, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kelly, WK | 1 |
| Scher, HI | 1 |
| Mazumdar, M | 1 |
| Pfister, D | 1 |
| Curley, T | 1 |
| Leibertz, C | 1 |
| Cohen, L | 1 |
| Vlamis, V | 1 |
| Dnistrian, A | 1 |
| Schwartz, M | 1 |
1 trial available for suramin and Lymphopenia
| Article | Year |
|---|---|
Suramin and hydrocortisone: determining drug efficacy in androgen-independent prostate cancer.
Topics: Adaptation, Physiological; Aged; Aged, 80 and over; Anemia; Cohort Studies; Drug Administration Sche | 1995 |