suramin has been researched along with Liver Failure, Acute in 2 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Liver Failure, Acute: A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of HEPATOCYTES. It is characterized by sudden development of liver dysfunction and JAUNDICE. Acute liver failure may progress to exhibit cerebral dysfunction even HEPATIC COMA depending on the etiology that includes hepatic ISCHEMIA, drug toxicity, malignant infiltration, and viral hepatitis such as post-transfusion HEPATITIS B and HEPATITIS C.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Suramin is a symmetrical polysulfonated naphthylamine derivative of urea." | 1.33 | Suramin prevents fulminant hepatic failure resulting in reduction of lethality through the suppression of NF-kappaB activity. ( Endo, A; Goto, T; Kataoka, E; Mikami, K; Miura, K; Ohshima, S; Sato, M; Sato, W; Segawa, D; Shibuya, T; Takeuchi, S; Watanabe, D; Watanabe, S; Yoneyama, K; Yoshino, R, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Doggrell, SA | 1 |
| Goto, T | 1 |
| Takeuchi, S | 1 |
| Miura, K | 1 |
| Ohshima, S | 1 |
| Mikami, K | 1 |
| Yoneyama, K | 1 |
| Sato, M | 1 |
| Shibuya, T | 1 |
| Watanabe, D | 1 |
| Kataoka, E | 1 |
| Segawa, D | 1 |
| Endo, A | 1 |
| Sato, W | 1 |
| Yoshino, R | 1 |
| Watanabe, S | 1 |
1 review available for suramin and Liver Failure, Acute
| Article | Year |
|---|---|
Suramin: potential in acute liver failure.
Topics: Animals; Apoptosis; Disease Models, Animal; Humans; Liver Failure, Acute; Suramin | 2004 |
1 other study available for suramin and Liver Failure, Acute
| Article | Year |
|---|---|
Suramin prevents fulminant hepatic failure resulting in reduction of lethality through the suppression of NF-kappaB activity.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Cell Line; Cytokines; Galactosamine; Int | 2006 |