suramin has been researched along with Liver Cirrhosis in 5 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Liver Cirrhosis: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Suramin is a polysulfonated naphthylurea, which was originally synthesized and designed as a treatment for trypanosomiasis and selected malignancies and metastatic diseases." | 2.47 | Tissue protective and anti-fibrotic actions of suramin: new uses of an old drug. ( Liu, N; Zhuang, S, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sastre, E | 1 |
| Caracuel, L | 1 |
| Prieto, I | 1 |
| Llévenes, P | 1 |
| Aller, MÁ | 1 |
| Arias, J | 1 |
| Balfagón, G | 1 |
| Blanco-Rivero, J | 1 |
| Li, C | 3 |
| Kong, Y | 1 |
| Wang, H | 1 |
| Wang, S | 1 |
| Yu, H | 1 |
| Liu, X | 3 |
| Yang, L | 3 |
| Jiang, X | 2 |
| Li, L | 4 |
| Yue, S | 1 |
| Zheng, S | 1 |
| You, H | 1 |
| Lin, M | 1 |
| Liu, N | 1 |
| Zhuang, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Umbilical Cord Mesenchymal Stem Cell Transfusion in Patients With Severe Liver Cirrhosis[NCT01233102] | Phase 1/Phase 2 | 200 participants (Anticipated) | Interventional | 2009-10-31 | Suspended | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for suramin and Liver Cirrhosis
| Article | Year |
|---|---|
Tissue protective and anti-fibrotic actions of suramin: new uses of an old drug.
Topics: Apoptosis; Cardiovascular Diseases; Humans; Kidney; Liver Cirrhosis; Muscle, Skeletal; Neuroprotecti | 2011 |
4 other studies available for suramin and Liver Cirrhosis
| Article | Year |
|---|---|
Decompensated liver cirrhosis and neural regulation of mesenteric vascular tone in rats: role of sympathetic, nitrergic and sensory innervations.
Topics: Animals; Liver Cirrhosis; Male; Mesenteric Artery, Superior; NG-Nitroarginine Methyl Ester; Nitric O | 2016 |
Homing of bone marrow mesenchymal stem cells mediated by sphingosine 1-phosphate contributes to liver fibrosis.
Topics: Animals; Base Sequence; Bone Marrow Cells; Bone Marrow Transplantation; Cell Differentiation; Cell M | 2009 |
Involvement of sphingosine 1-phosphate (SIP)/S1P3 signaling in cholestasis-induced liver fibrosis.
Topics: Animals; Bone Marrow Cells; Cell Movement; Cholestasis; Liver Cirrhosis; Lysophospholipids; Mice; Re | 2009 |
Sphingosine 1-phosphate (S1P)/S1P receptors are involved in human liver fibrosis by action on hepatic myofibroblasts motility.
Topics: Base Sequence; Cell Movement; Cells, Cultured; Humans; Liver Cirrhosis; Lysophospholipids; Myofibrob | 2011 |