suramin has been researched along with Leukodystrophy, Globoid Cell in 2 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Leukodystrophy, Globoid Cell: An autosomal recessive metabolic disorder caused by a deficiency of GALACTOSYLCERAMIDASE leading to intralysosomal accumulation of galactolipids such as GALACTOSYLCERAMIDES and PSYCHOSINE. It is characterized by demyelination associated with large multinucleated globoid cells, predominantly involving the white matter of the central nervous system. The loss of MYELIN disrupts normal conduction of nerve impulses.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In vivo studies were carried out on dental tissues of rat incisor after a single injection of suramin, a drug which induces mucopolysaccharidosis-like disease." | 3.68 | [Lysosomal storage diseases, genetic or drug-induced? effect of glycosaminoglycan and sphingolipid disorders on dental tissues]. ( Bloch-Zupan, A; Goldberg, M; Gritli, A; Lécolle, S; Legrand, JM; Ruch, JV; Septier, D, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Goldberg, M | 2 |
| Septier, D | 2 |
| Lécolle, S | 2 |
| Vermelin, L | 1 |
| Bissila-Mapahou, P | 1 |
| Carreau, JP | 1 |
| Gritli, A | 2 |
| Bloch-Zupan, A | 2 |
| Legrand, JM | 1 |
| Ruch, JV | 1 |
1 review available for suramin and Leukodystrophy, Globoid Cell
| Article | Year |
|---|---|
Lipids in predentine and dentine.
Topics: Animals; Autoradiography; Collagen; Coloring Agents; Dentin; Dentinogenesis; Extracellular Matrix; H | 1995 |
1 other study available for suramin and Leukodystrophy, Globoid Cell
| Article | Year |
|---|---|
[Lysosomal storage diseases, genetic or drug-induced? effect of glycosaminoglycan and sphingolipid disorders on dental tissues].
Topics: Ameloblasts; Animals; Child; Dentin; Glycosaminoglycans; Humans; In Vitro Techniques; Leukodystrophy | 1993 |