suramin and Leukemia
suramin has been researched along with Leukemia in 5 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Suramin treatments were administered (IV) to 2 healthy adult cats infected with naturally acquired feline leukemia virus." | 7.67 | Effect of suramin on serum viral replication in feline leukemia virus-infected pet cats. ( Cogan, DC; Cotter, SM; Kitchen, LW, 1986) |
| "Suramin treatments were administered (IV) to 2 healthy adult cats infected with naturally acquired feline leukemia virus." | 3.67 | Effect of suramin on serum viral replication in feline leukemia virus-infected pet cats. ( Cogan, DC; Cotter, SM; Kitchen, LW, 1986) |
| "Suramin is a more potent (IC50, 0." | 1.29 | Potent inhibition of human folylpolyglutamate synthetase by suramin. ( Haile, WH; McGuire, JJ, 1996) |
Research
Studies (5)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Eadsforth, TC | 1 |
| Pinto, A | 1 |
| Luciani, R | 1 |
| Tamborini, L | 1 |
| Cullia, G | 1 |
| De Micheli, C | 1 |
| Marinelli, L | 1 |
| Cosconati, S | 1 |
| Novellino, E | 1 |
| Lo Presti, L | 1 |
| Cordeiro da Silva, A | 1 |
| Conti, P | 1 |
| Hunter, WN | 1 |
| Costi, MP | 1 |
| Karim, H | 1 |
| Bogason, A | 1 |
| Bhuiyan, H | 1 |
| Fotoohi, AK | 1 |
| Lafolie, P | 1 |
| Vitols, S | 1 |
| Cheson, BD | 1 |
| Phillips, PH | 1 |
| Pluda, JM | 1 |
| Christian, M | 1 |
| McGuire, JJ | 1 |
| Haile, WH | 1 |
| Cogan, DC | 1 |
| Cotter, SM | 1 |
| Kitchen, LW | 1 |
Other Studies
5 other studies available for suramin and Leukemia
| Article | Year |
|---|---|
Characterization of 2,4-Diamino-6-oxo-1,6-dihydropyrimidin-5-yl Ureido Based Inhibitors of Trypanosoma brucei FolD and Testing for Antiparasitic Activity.
Topics: Animals; Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; Humans; Leukemia; Macrophages; Meth | 2015 |
Comparison of uptake mechanisms for anthracyclines in human leukemic cells.
Topics: Anthracyclines; Antibiotics, Antineoplastic; Apoptosis; ATP Binding Cassette Transporter, Subfamily | 2013 |
Clinical trials referral resource. Clinical trials of suramin.
Topics: Antineoplastic Agents; Breast Neoplasms; Clinical Trials as Topic; Humans; Leukemia; Lymphoma; Suram | 1995 |
Potent inhibition of human folylpolyglutamate synthetase by suramin.
Topics: Animals; Binding, Competitive; Cattle; Cell Line; Enzyme Inhibitors; Humans; Kinetics; Leukemia; Pep | 1996 |
Effect of suramin on serum viral replication in feline leukemia virus-infected pet cats.
Topics: Animals; Antibodies, Viral; Antigens, Viral; Cat Diseases; Cats; Female; Leukemia; Leukemia Virus, F | 1986 |