Page last updated: 2024-11-04

suramin and Leukemia

suramin has been researched along with Leukemia in 5 studies

Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.

Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)

Research Excerpts

ExcerptRelevanceReference
"Suramin treatments were administered (IV) to 2 healthy adult cats infected with naturally acquired feline leukemia virus."7.67Effect of suramin on serum viral replication in feline leukemia virus-infected pet cats. ( Cogan, DC; Cotter, SM; Kitchen, LW, 1986)
"Suramin treatments were administered (IV) to 2 healthy adult cats infected with naturally acquired feline leukemia virus."3.67Effect of suramin on serum viral replication in feline leukemia virus-infected pet cats. ( Cogan, DC; Cotter, SM; Kitchen, LW, 1986)
"Suramin is a more potent (IC50, 0."1.29Potent inhibition of human folylpolyglutamate synthetase by suramin. ( Haile, WH; McGuire, JJ, 1996)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19901 (20.00)18.7374
1990's2 (40.00)18.2507
2000's0 (0.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Eadsforth, TC1
Pinto, A1
Luciani, R1
Tamborini, L1
Cullia, G1
De Micheli, C1
Marinelli, L1
Cosconati, S1
Novellino, E1
Lo Presti, L1
Cordeiro da Silva, A1
Conti, P1
Hunter, WN1
Costi, MP1
Karim, H1
Bogason, A1
Bhuiyan, H1
Fotoohi, AK1
Lafolie, P1
Vitols, S1
Cheson, BD1
Phillips, PH1
Pluda, JM1
Christian, M1
McGuire, JJ1
Haile, WH1
Cogan, DC1
Cotter, SM1
Kitchen, LW1

Other Studies

5 other studies available for suramin and Leukemia

ArticleYear
Characterization of 2,4-Diamino-6-oxo-1,6-dihydropyrimidin-5-yl Ureido Based Inhibitors of Trypanosoma brucei FolD and Testing for Antiparasitic Activity.
    Journal of medicinal chemistry, 2015, Oct-22, Volume: 58, Issue:20

    Topics: Animals; Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; Humans; Leukemia; Macrophages; Meth

2015
Comparison of uptake mechanisms for anthracyclines in human leukemic cells.
    Current drug delivery, 2013, Volume: 10, Issue:4

    Topics: Anthracyclines; Antibiotics, Antineoplastic; Apoptosis; ATP Binding Cassette Transporter, Subfamily

2013
Clinical trials referral resource. Clinical trials of suramin.
    Oncology (Williston Park, N.Y.), 1995, Volume: 9, Issue:2

    Topics: Antineoplastic Agents; Breast Neoplasms; Clinical Trials as Topic; Humans; Leukemia; Lymphoma; Suram

1995
Potent inhibition of human folylpolyglutamate synthetase by suramin.
    Archives of biochemistry and biophysics, 1996, Nov-01, Volume: 335, Issue:1

    Topics: Animals; Binding, Competitive; Cattle; Cell Line; Enzyme Inhibitors; Humans; Kinetics; Leukemia; Pep

1996
Effect of suramin on serum viral replication in feline leukemia virus-infected pet cats.
    American journal of veterinary research, 1986, Volume: 47, Issue:10

    Topics: Animals; Antibodies, Viral; Antigens, Viral; Cat Diseases; Cats; Female; Leukemia; Leukemia Virus, F

1986