suramin has been researched along with Leukemia, Myeloid in 2 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Leukemia, Myeloid: Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (MYELOID PROGENITOR CELLS) in the bone marrow and other sites.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Abe, S | 1 |
| Funato, T | 1 |
| Takahashi, S | 1 |
| Yokoyama, H | 1 |
| Yamamoto, J | 1 |
| Tomiya, Y | 1 |
| Yamada-Fujiwara, M | 1 |
| Ishizawa, K | 1 |
| Kameoka, J | 1 |
| Kaku, M | 1 |
| Harigae, H | 1 |
| Sasaki, T | 1 |
| Carrier, F | 1 |
| Zhan, Q | 1 |
| Alamo, I | 1 |
| Hanaoka, F | 1 |
| Fornace, AJ | 1 |
2 other studies available for suramin and Leukemia, Myeloid
| Article | Year |
|---|---|
Increased expression of insulin-like growth factor i is associated with Ara-C resistance in leukemia.
Topics: Acute Disease; Adult; Aged; Apoptosis; Cytarabine; Drug Resistance, Neoplasm; Female; Gene Expressio | 2006 |
Evidence for distinct kinase-mediated pathways in gadd gene responses.
Topics: Animals; Cell Division; CHO Cells; Cricetinae; DNA Damage; Enzyme Induction; Enzyme Inhibitors; Gene | 1998 |