suramin has been researched along with B-Cell Chronic Lymphocytic Leukemia in 2 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Van Den Neste, E | 1 |
| Smal, C | 1 |
| Cardoen, S | 1 |
| Delacauw, A | 1 |
| Frankard, J | 1 |
| Ferrant, A | 1 |
| Van den Berghe, G | 1 |
| Bontemps, F | 1 |
| Wiley, JS | 1 |
| Chen, R | 1 |
| Jamieson, GP | 1 |
2 other studies available for suramin and B-Cell Chronic Lymphocytic Leukemia
| Article | Year |
|---|---|
Activation of deoxycytidine kinase by UV-C-irradiation in chronic lymphocytic leukemia B-lymphocytes.
Topics: Antineoplastic Agents; B-Lymphocytes; Deoxycytidine Kinase; DNA Repair; Enzyme Activation; Humans; L | 2003 |
The ATP4- receptor-operated channel (P2Z class) of human lymphocytes allows Ba2+ and ethidium+ uptake: inhibition of fluxes by suramin.
Topics: Adenosine Triphosphate; Barium; Biological Transport; Calcium; Ethidium; Flow Cytometry; Humans; Ion | 1993 |