suramin has been researched along with Lacerations in 1 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Lacerations: Torn, ragged, mangled wounds.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Suramin has been found to inhibit transforming growth factor (TGF)-beta1 expression by competitively binding to the growth factor receptor." | 1.32 | Antifibrotic effects of suramin in injured skeletal muscle after laceration. ( Chan, YS; Foster, W; Fu, FH; Horaguchi, T; Huard, J; Li, Y; Somogyi, G, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chan, YS | 1 |
| Li, Y | 1 |
| Foster, W | 1 |
| Horaguchi, T | 1 |
| Somogyi, G | 1 |
| Fu, FH | 1 |
| Huard, J | 1 |
1 other study available for suramin and Lacerations
| Article | Year |
|---|---|
Antifibrotic effects of suramin in injured skeletal muscle after laceration.
Topics: 3T3 Cells; Actins; Animals; Blotting, Western; Fibroblasts; Fibrosis; Injections; Intracellular Memb | 2003 |