suramin has been researched along with Kidney Diseases in 2 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Kidney Diseases: Pathological processes of the KIDNEY or its component tissues.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Suramin is a compound that inhibits the interaction of several cytokines and growth factors with their receptors, but whether suramin inhibits the progression of renal fibrosis is unknown." | 5.37 | Suramin inhibits renal fibrosis in chronic kidney disease. ( Liu, N; Pang, M; Ponnusamy, M; Tolbert, E; Yan, H; Zhuang, S, 2011) |
| "We used population pharmacokinetic-parameter estimates and designed a fixed dosing schedule to maintain plasma suramin concentrations between 100 and 300 micrograms/mL and then evaluated its performance." | 2.68 | Development and validation of a pharmacokinetically based fixed dosing scheme for suramin. ( Egorin, MJ; Eisenberger, MA; Reyno, LM; Sinibaldi, VJ; Sridhara, R; Zuhowski, EG, 1995) |
| "Suramin is a compound that inhibits the interaction of several cytokines and growth factors with their receptors, but whether suramin inhibits the progression of renal fibrosis is unknown." | 1.37 | Suramin inhibits renal fibrosis in chronic kidney disease. ( Liu, N; Pang, M; Ponnusamy, M; Tolbert, E; Yan, H; Zhuang, S, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, N | 1 |
| Tolbert, E | 1 |
| Pang, M | 1 |
| Ponnusamy, M | 1 |
| Yan, H | 1 |
| Zhuang, S | 1 |
| Reyno, LM | 1 |
| Egorin, MJ | 1 |
| Eisenberger, MA | 1 |
| Sinibaldi, VJ | 1 |
| Zuhowski, EG | 1 |
| Sridhara, R | 1 |
1 trial available for suramin and Kidney Diseases
| Article | Year |
|---|---|
Development and validation of a pharmacokinetically based fixed dosing scheme for suramin.
Topics: Adult; Aged; Aged, 80 and over; Disease-Free Survival; Drug Administration Schedule; Drug Monitoring | 1995 |
1 other study available for suramin and Kidney Diseases
| Article | Year |
|---|---|
Suramin inhibits renal fibrosis in chronic kidney disease.
Topics: Actins; Animals; Antineoplastic Agents; Cells, Cultured; Chronic Disease; Disease Models, Animal; Di | 2011 |