suramin has been researched along with Invasiveness, Neoplasm in 9 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The treatment of patients with invasive breast cancer remains a major issue because of the acquisition of drug resistance to conventional chemotherapy." | 5.40 | A combination treatment with DNA methyltransferase inhibitors and suramin decreases invasiveness of breast cancer cells. ( Borges, S; Döppler, HR; Storz, P, 2014) |
| "The treatment of patients with invasive breast cancer remains a major issue because of the acquisition of drug resistance to conventional chemotherapy." | 1.40 | A combination treatment with DNA methyltransferase inhibitors and suramin decreases invasiveness of breast cancer cells. ( Borges, S; Döppler, HR; Storz, P, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (66.67) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Borges, S | 1 |
| Döppler, HR | 1 |
| Storz, P | 1 |
| Marchetti, D | 1 |
| Reiland, J | 1 |
| Erwin, B | 1 |
| Roy, M | 1 |
| Garrido, T | 1 |
| Riese, HH | 1 |
| Aracil, M | 1 |
| Pérez-Aranda, A | 1 |
| Droller, MJ | 1 |
| Taylor, WR | 1 |
| Greenberg, AH | 1 |
| Turley, EA | 1 |
| Wright, JA | 1 |
| Samid, D | 1 |
| Shack, S | 1 |
| Myers, CE | 1 |
| Kakeji, Y | 1 |
| Teicher, BA | 1 |
| Rodier, JM | 1 |
| Pujade-Lauraine, E | 1 |
| Fujiyama, C | 1 |
| Jones, A | 1 |
| Fuggle, S | 1 |
| Bicknell, R | 1 |
| Cranston, D | 1 |
| Harris, AL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase II Trial of Phenylbutyrate Given as a Continuous Infusion in Pediatric Patients With Progressive or Recurrent CNS Malignancy[NCT00006450] | Phase 2 | 120 participants | Interventional | 2000-11-30 | Completed | ||
| Phase I and Pharmacokinetic Trial of Phenylbutyrate Given as a Continuous Infusion in Pediatric Patients With Refractory Malignancy[NCT00001565] | Phase 1 | 35 participants | Interventional | 1996-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 other studies available for suramin and Invasiveness, Neoplasm
| Article | Year |
|---|---|
A combination treatment with DNA methyltransferase inhibitors and suramin decreases invasiveness of breast cancer cells.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Breast Neoplasms; Cell Line, T | 2014 |
Inhibition of heparanase activity and heparanase-induced angiogenesis by suramin analogues.
Topics: Antineoplastic Agents; Cell Division; Dose-Response Relationship, Drug; Glucuronidase; Humans; Neopl | 2003 |
Endothelial cell differentiation into capillary-like structures in response to tumour cell conditioned medium: a modified chemotaxis chamber assay.
Topics: Adenocarcinoma; Animals; Antibodies; Aorta; Breast Neoplasms; Capillaries; Cattle; Cell Differentiat | 1995 |
This month in Investigative Urology. A commentary on suramin demonstrates in vitro toxicity against transitional cell carcinoma cell lines and exposure to alkyllysophospholipids inhibits in vitro invasion of transitional cell carcinoma.
Topics: Antineoplastic Agents; Carcinoma, Transitional Cell; Drug Screening Assays, Antitumor; Humans; Neopl | 1994 |
Cell motility, invasion, and malignancy induced by overexpression of K-FGF or bFGF.
Topics: 3T3 Cells; Animals; Cell Movement; Fibroblast Growth Factor 2; Fibroblast Growth Factor 4; Fibroblas | 1993 |
Selective growth arrest and phenotypic reversion of prostate cancer cells in vitro by nontoxic pharmacological concentrations of phenylacetate.
Topics: Animals; Cell Division; Cell Survival; DNA Replication; Female; Glutamine; HLA-A3 Antigen; Humans; M | 1993 |
Selective growth arrest and phenotypic reversion of prostate cancer cells in vitro by nontoxic pharmacological concentrations of phenylacetate.
Topics: Animals; Cell Division; Cell Survival; DNA Replication; Female; Glutamine; HLA-A3 Antigen; Humans; M | 1993 |
Selective growth arrest and phenotypic reversion of prostate cancer cells in vitro by nontoxic pharmacological concentrations of phenylacetate.
Topics: Animals; Cell Division; Cell Survival; DNA Replication; Female; Glutamine; HLA-A3 Antigen; Humans; M | 1993 |
Selective growth arrest and phenotypic reversion of prostate cancer cells in vitro by nontoxic pharmacological concentrations of phenylacetate.
Topics: Animals; Cell Division; Cell Survival; DNA Replication; Female; Glutamine; HLA-A3 Antigen; Humans; M | 1993 |
Preclinical studies of the combination of angiogenic inhibitors with cytotoxic agents.
Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Anti | 1997 |
[Autocrine stimulation of cell proliferation in colonic carcinoma: a biological curiosity or a new therapeutic target?].
Topics: Antineoplastic Agents; Cell Division; Colonic Neoplasms; Epidermal Growth Factor; Humans; Neoplasm I | 1995 |
Human bladder cancer invasion model using rat bladder in vitro and its use to test mechanisms and therapeutic inhibitors of invasion.
Topics: Acetylcysteine; Administration, Intravesical; Animals; Antineoplastic Agents; Carcinoma, Transitiona | 2001 |