suramin has been researched along with Inflammation in 23 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the efficacy and safety of suramin, genistein and collagen matrix for the prevention of inflammation, the reduction of fibrosis and the delay in adjustment after strabismus surgery on a rabbit model." | 7.83 | Suramin, Genistein and Collagen Matrix (DuraGen) for Delayed Adjustment after Strabismus Surgery: Which One is Best? ( Akova, YA; Bakar, C; Oktem, C; Oto, S; Ozdemir, H; Toru, S, 2016) |
| "Suramin is an anti-parasitic drug that has potent anti-purinergic properties." | 5.91 | Suramin ameliorates osteoarthritis by acting on the Nrf2/HO-1 and NF-κB signaling pathways in chondrocytes and promoting M2 polarization in macrophages. ( Chou, SH; Huang, SH; Liu, ZM; Lu, CC; Shen, PC; Tien, YC, 2023) |
| "To evaluate the efficacy and safety of suramin, genistein and collagen matrix for the prevention of inflammation, the reduction of fibrosis and the delay in adjustment after strabismus surgery on a rabbit model." | 3.83 | Suramin, Genistein and Collagen Matrix (DuraGen) for Delayed Adjustment after Strabismus Surgery: Which One is Best? ( Akova, YA; Bakar, C; Oktem, C; Oto, S; Ozdemir, H; Toru, S, 2016) |
| "Suramin can protect LPS-induced acute lung injury through down-regulation of systemic and pulmonary pro-inflammatory factors, which may be associated with the inhibition of NF-κB activity." | 3.81 | [Inhibitory effect of suramin on inflammatory response in pulmonary tissue and peripheral blood in LPS-induced septic mice]. ( Fang, XM; Han, L; Hou, JC, 2015) |
| " In order to determine if the endogenous opioid system is involved in this antinociception, naloxone was administered just prior to the injection of a selective P2X3/P2X2/3 receptor antagonist, A-317491, in rat models of neuropathic, chemogenic, and inflammatory pain." | 3.73 | Endogenous opioid mechanisms partially mediate P2X3/P2X2/3-related antinociception in rat models of inflammatory and chemogenic pain but not neuropathic pain. ( Bianchi, B; Faltynek, CR; Honore, P; Jarvis, MF; McDonald, HA; McGaraughty, S; Mikusa, J; Wismer, CT; Zhu, CZ, 2005) |
| "Suramin is an anti-parasitic drug that has potent anti-purinergic properties." | 1.91 | Suramin ameliorates osteoarthritis by acting on the Nrf2/HO-1 and NF-κB signaling pathways in chondrocytes and promoting M2 polarization in macrophages. ( Chou, SH; Huang, SH; Liu, ZM; Lu, CC; Shen, PC; Tien, YC, 2023) |
| "In vivo, results showed that the hepatoprotective effect of P2Y2R blockade by significantly suppressed liver structural abnormalities and lipid infiltration, and decreased levels of ALT/AST and TNF-α/IL-1β in the high dosage group of suramin (20 mg/kg) compared to control diet (CD)-fed mice." | 1.72 | Blockade of the P2Y2 Receptor Attenuates Alcoholic Liver Inflammation by Targeting the EGFR-ERK1/2 Signaling Pathway. ( Liu, ZN; Lv, XW; Su, QQ; Wang, YH; Wu, X, 2022) |
| "Suramin was also effective in blocking CG-induced phosphorylation of inhibitor of κB (IκB) and nuclear factor (NF)-κBp65, expression of several inflammatory cytokines, and infiltration of macrophages in the peritoneum." | 1.40 | Suramin inhibits the development and progression of peritoneal fibrosis. ( Fang, L; Liu, N; Xiong, C; Yan, H; Zhuang, S, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (17.39) | 18.2507 |
| 2000's | 8 (34.78) | 29.6817 |
| 2010's | 9 (39.13) | 24.3611 |
| 2020's | 2 (8.70) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, ZN | 1 |
| Su, QQ | 1 |
| Wang, YH | 1 |
| Wu, X | 1 |
| Lv, XW | 1 |
| Shen, PC | 1 |
| Huang, SH | 1 |
| Liu, ZM | 1 |
| Lu, CC | 1 |
| Chou, SH | 1 |
| Tien, YC | 1 |
| Dixit, A | 1 |
| Cheema, H | 1 |
| George, J | 1 |
| Iyer, S | 1 |
| Dudeja, V | 1 |
| Dawra, R | 1 |
| Saluja, AK | 1 |
| Kuang, Y | 1 |
| Liu, H | 1 |
| Guo, S | 1 |
| Wang, Y | 1 |
| Zhang, H | 1 |
| Qiao, Y | 1 |
| Xiong, C | 1 |
| Liu, N | 1 |
| Fang, L | 1 |
| Zhuang, S | 1 |
| Yan, H | 1 |
| Oktem, C | 1 |
| Oto, S | 1 |
| Toru, S | 1 |
| Bakar, C | 1 |
| Ozdemir, H | 1 |
| Akova, YA | 1 |
| Gadotti, VM | 1 |
| Caballero, AG | 1 |
| Berger, ND | 1 |
| Gladding, CM | 1 |
| Chen, L | 1 |
| Pfeifer, TA | 1 |
| Zamponi, GW | 1 |
| Alyoussef, A | 1 |
| Calvén, J | 1 |
| Akbarshahi, H | 1 |
| Menzel, M | 1 |
| Ayata, CK | 1 |
| Idzko, M | 2 |
| Bjermer, L | 1 |
| Uller, L | 1 |
| Han, L | 1 |
| Hou, JC | 1 |
| Fang, XM | 1 |
| Ballok, DA | 1 |
| Sakic, B | 1 |
| Taylor, JM | 1 |
| Han, Z | 1 |
| McGaraughty, S | 1 |
| Honore, P | 1 |
| Wismer, CT | 1 |
| Mikusa, J | 1 |
| Zhu, CZ | 1 |
| McDonald, HA | 1 |
| Bianchi, B | 1 |
| Faltynek, CR | 1 |
| Jarvis, MF | 1 |
| Seiffert, K | 1 |
| Ding, W | 1 |
| Wagner, JA | 1 |
| Granstein, RD | 1 |
| Hammad, H | 1 |
| van Nimwegen, M | 1 |
| Kool, M | 1 |
| Willart, MA | 1 |
| Muskens, F | 1 |
| Hoogsteden, HC | 1 |
| Luttmann, W | 1 |
| Ferrari, D | 1 |
| Di Virgilio, F | 1 |
| Virchow, JC | 1 |
| Lambrecht, BN | 1 |
| Braddock, PS | 1 |
| Hu, DE | 1 |
| Fan, TP | 1 |
| Stratford, IJ | 1 |
| Harris, AL | 1 |
| Bicknell, R | 1 |
| Estrov, Z | 1 |
| Kurzrock, R | 1 |
| Talpaz, M | 1 |
| Ziganshina, LE | 1 |
| Ziganshin, AU | 1 |
| Hoyle, CH | 1 |
| Burnstock, G | 1 |
| Palmetshofer, A | 1 |
| Robson, SC | 1 |
| Nehls, V | 1 |
| Stanfa, LC | 1 |
| Kontinen, VK | 1 |
| Dickenson, AH | 1 |
| Zhang, YH | 1 |
| Chen, Y | 1 |
| Zhao, ZQ | 1 |
| John, GR | 1 |
| Simpson, JE | 1 |
| Woodroofe, MN | 1 |
| Lee, SC | 1 |
| Brosnan, CF | 1 |
| Shiono, T | 1 |
| Kodama, M | 1 |
| Hanawa, H | 1 |
| Fuse, K | 1 |
| Yamamoto, T | 1 |
| Aizawa, Y | 1 |
1 review available for suramin and Inflammation
| Article | Year |
|---|---|
Interleukin-1 and its inhibitors: implications for disease biology and therapy.
Topics: Animals; Antineoplastic Agents; Bone Marrow Diseases; Caspase 1; Cysteine Endopeptidases; Gene Expre | 1995 |
1 trial available for suramin and Inflammation
| Article | Year |
|---|---|
Interleukin-1 and its inhibitors: implications for disease biology and therapy.
Topics: Animals; Antineoplastic Agents; Bone Marrow Diseases; Caspase 1; Cysteine Endopeptidases; Gene Expre | 1995 |
22 other studies available for suramin and Inflammation
| Article | Year |
|---|---|
Blockade of the P2Y2 Receptor Attenuates Alcoholic Liver Inflammation by Targeting the EGFR-ERK1/2 Signaling Pathway.
Topics: Animals; ErbB Receptors; Inflammation; Leukemia, Myeloid, Acute; Liver; MAP Kinase Signaling System; | 2022 |
Suramin ameliorates osteoarthritis by acting on the Nrf2/HO-1 and NF-κB signaling pathways in chondrocytes and promoting M2 polarization in macrophages.
Topics: Animals; Cartilage, Articular; Chondrocytes; Inflammation; Interleukin-1beta; Macrophages; Mice; NF- | 2023 |
Extracellular release of ATP promotes systemic inflammation during acute pancreatitis.
Topics: Acute Disease; Adenosine Triphosphate; Animals; Apyrase; Arginine; Bronchoalveolar Lavage Fluid; Cer | 2019 |
The antagonist of P2Y11 receptor NF157 ameliorates oxidized LDL-induced vascular endothelial inflammation.
Topics: Cell Adhesion; E-Selectin; Enzyme Activation; Gene Expression Regulation; Human Umbilical Vein Endot | 2019 |
Suramin inhibits the development and progression of peritoneal fibrosis.
Topics: Actins; Angiogenesis Inducing Agents; Animals; Collagen Type I; Cytokines; Disease Models, Animal; D | 2014 |
Suramin, Genistein and Collagen Matrix (DuraGen) for Delayed Adjustment after Strabismus Surgery: Which One is Best?
Topics: Animals; Antineoplastic Agents; Biomarkers; Collagen; Conjunctiva; Endoglin; Epithelium; Female; Fib | 2016 |
Small organic molecule disruptors of Cav3.2 - USP5 interactions reverse inflammatory and neuropathic pain.
Topics: Analgesics; Animals; Calcium Channels, T-Type; Ganglia, Spinal; Humans; Hyperalgesia; Inflammation; | 2015 |
Suramin attenuated inflammation and reversed skin tissue damage in experimentally induced atopic dermatitis in mice.
Topics: Animals; Anti-Inflammatory Agents; Behavior, Animal; Cytokines; Dermatitis, Atopic; Dinitrochloroben | 2015 |
Rhinoviral stimuli, epithelial factors and ATP signalling contribute to bronchial smooth muscle production of IL-33.
Topics: Adenosine Triphosphate; Asthma; Bronchi; Cells, Cultured; Culture Media, Conditioned; DEAD Box Prote | 2015 |
[Inhibitory effect of suramin on inflammatory response in pulmonary tissue and peripheral blood in LPS-induced septic mice].
Topics: Acute Lung Injury; Animals; Cell Line; Down-Regulation; Gene Expression Regulation; Inflammation; In | 2015 |
Purine receptor antagonist modulates serology and affective behaviors in lupus-prone mice: evidence of autoimmune-induced pain?
Topics: Analysis of Variance; Animals; Anxiety; Autoantibodies; Autoimmunity; Body Weight; Cell Shape; Dendr | 2008 |
Purinergic receptor functionality is necessary for infection of human hepatocytes by hepatitis delta virus and hepatitis B virus.
Topics: Animals; Cell Line; Hepatitis B virus; Hepatitis Delta Virus; Hepatocytes; Humans; Inflammation; Pyr | 2010 |
Endogenous opioid mechanisms partially mediate P2X3/P2X2/3-related antinociception in rat models of inflammatory and chemogenic pain but not neuropathic pain.
Topics: Analgesia; Animals; Arthritis, Experimental; Dose-Response Relationship, Drug; Endorphins; Formaldeh | 2005 |
ATPgammaS enhances the production of inflammatory mediators by a human dermal endothelial cell line via purinergic receptor signaling.
Topics: Adenosine Triphosphate; Apoptosis; Cell Line; Chemokine CCL2; Chemokine CXCL1; Chemokines, CXC; Endo | 2006 |
Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells.
Topics: Adenosine Triphosphate; Animals; Asthma; Cell Differentiation; Dendritic Cells; Humans; Inflammation | 2007 |
A structure-activity analysis of antagonism of the growth factor and angiogenic activity of basic fibroblast growth factor by suramin and related polyanions.
Topics: Animals; Capillaries; Cattle; Cell Division; Cells, Cultured; Dose-Response Relationship, Drug; Endo | 1994 |
Acute paw oedema formation induced by ATP: re-evaluation of the mechanisms involved.
Topics: Adenosine Triphosphate; Animals; Dose-Response Relationship, Drug; Edema; Histamine; Inflammation; M | 1996 |
Lysophosphatidic acid activates nuclear factor kappa B and induces proinflammatory gene expression in endothelial cells.
Topics: Animals; Cells, Cultured; Chemokine CCL2; Drug Synergism; E-Selectin; Endothelium, Vascular; Gene Ex | 1999 |
Effects of spinally administered P2X receptor agonists and antagonists on the responses of dorsal horn neurones recorded in normal, carrageenan-inflamed and neuropathic rats.
Topics: Adenosine Triphosphate; Animals; Carrageenan; Electrophysiology; Inflammation; Injections, Spinal; M | 2000 |
Alteration of spontaneous firing rate of primary myelinated afferents by ATP in adjuvant-induced inflamed rats.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Antineoplastic Agents; Enzyme Inhibitors; Freund | 2001 |
Extracellular nucleotides differentially regulate interleukin-1beta signaling in primary human astrocytes: implications for inflammatory gene expression.
Topics: Adenosine Triphosphate; Astrocytes; Cells, Cultured; Chemokine CXCL10; Chemokines, CXC; Drug Synergi | 2001 |
Suppression of myocardial inflammation using suramin, a growth factor blocker.
Topics: Animals; Anti-Inflammatory Agents; Autoimmune Diseases; Cardiomyopathies; Cytokines; Growth Inhibito | 2002 |