suramin has been researched along with Infections, Retroviridae in 5 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Suramin was given to ten outpatients with acquired immunodeficiency syndrome (AIDS) presenting as Kaposi's sarcoma (KS) or as an AIDS-related complex (ARC)." | 3.67 | Effects of suramin on HTLV-III/LAV infection presenting as Kaposi's sarcoma or AIDS-related complex: clinical pharmacology and suppression of virus replication in vivo. ( Broder, S; Collins, JM; Gelmann, E; Hoth, DF; Klecker, RW; Lane, HC; Markham, PD; Mitsuya, H; Redfield, RR; Yarchoan, R, 1985) |
| "The pathogenesis of AIDS involves the destruction of helper/inducer T-lymphocytes by active viral infection, and drugs which inhibit the replication of HTLV-III or monoclonal antibodies directed at viral antigens may be important components of future therapeutic strategies." | 2.66 | Implications of the discovery of HTLV-III for the treatment of AIDS. ( Broder, S; Matsushita, S; Mitsuya, H; Yarchoan, R, 1985) |
| "Suramin is an active antiretroviral agent whose effect on retroviral propagation is reversible." | 1.27 | Suppression of retroviral propagation and disease by suramin in murine systems. ( Broder, S; Haseltine, WA; Rossoni, LD; Ruprecht, RM, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| De Clercq, E | 2 |
| Yarchoan, R | 2 |
| Mitsuya, H | 2 |
| Matsushita, S | 1 |
| Broder, S | 3 |
| Ruprecht, RM | 1 |
| Rossoni, LD | 1 |
| Haseltine, WA | 1 |
| Collins, JM | 1 |
| Lane, HC | 1 |
| Markham, PD | 1 |
| Klecker, RW | 1 |
| Redfield, RR | 1 |
| Hoth, DF | 1 |
| Gelmann, E | 1 |
2 reviews available for suramin and Infections, Retroviridae
| Article | Year |
|---|---|
Chemotherapeutic approaches to the treatment of the acquired immune deficiency syndrome (AIDS).
Topics: Acquired Immunodeficiency Syndrome; Adsorption; Antibodies, Viral; Antigens, Viral; Aurintricarboxyl | 1986 |
Recent trends and development in antiviral chemotherapy.
Topics: Acyclovir; Antiviral Agents; Chemical Phenomena; Chemistry; DNA, Viral; Ganciclovir; Herpesviridae I | 1985 |
1 trial available for suramin and Infections, Retroviridae
| Article | Year |
|---|---|
Implications of the discovery of HTLV-III for the treatment of AIDS.
Topics: Acquired Immunodeficiency Syndrome; Clinical Trials as Topic; Deltaretrovirus; DNA, Viral; Humans; L | 1985 |
2 other studies available for suramin and Infections, Retroviridae
| Article | Year |
|---|---|
Suppression of retroviral propagation and disease by suramin in murine systems.
Topics: Animals; Female; Hematopoietic Stem Cells; Leukemia, Experimental; Mice; Mice, Inbred BALB C; Rausch | 1985 |
Effects of suramin on HTLV-III/LAV infection presenting as Kaposi's sarcoma or AIDS-related complex: clinical pharmacology and suppression of virus replication in vivo.
Topics: Acquired Immunodeficiency Syndrome; Adult; Deltaretrovirus; Humans; Male; Middle Aged; Retroviridae | 1985 |