suramin and Hypoxia
suramin has been researched along with Hypoxia in 11 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this study the effect of suramin on tumor growth, vascularity and oxygenation of a human glioma xenografted in the nude mouse was examined." | 7.70 | Suramin treatment of human glioma xenografts; effects on tumor vasculature and oxygenation status. ( Bakker, JH; Bernsen, HJ; Boerman, RH; Peters, JP; Rijken, PF; van der Kogel, AJ; Wesseling, P, 1999) |
| " The nicotinic blocker mecamylamine (50 microM) ablated the excitatory actions of exogenous ACh and increased, rather than decreased, AP activity during moderate hypoxia." | 3.75 | Nicotinic acetylcholine receptors do not mediate excitatory transmission in young rat carotid body. ( Donnelly, DF, 2009) |
| "In this study the effect of suramin on tumor growth, vascularity and oxygenation of a human glioma xenografted in the nude mouse was examined." | 3.70 | Suramin treatment of human glioma xenografts; effects on tumor vasculature and oxygenation status. ( Bakker, JH; Bernsen, HJ; Boerman, RH; Peters, JP; Rijken, PF; van der Kogel, AJ; Wesseling, P, 1999) |
Research
Studies (11)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 6 (54.55) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Vandorpe, DH | 1 |
| Rivera, A | 1 |
| Ganter, M | 1 |
| Dankwa, S | 1 |
| Wohlgemuth, JG | 1 |
| Dlott, JS | 1 |
| Snyder, LM | 1 |
| Brugnara, C | 1 |
| Duraisingh, M | 1 |
| Alper, SL | 1 |
| Rahbar, S | 1 |
| Pan, W | 1 |
| Jonz, MG | 1 |
| Visovatti, SH | 1 |
| Hyman, MC | 1 |
| Goonewardena, SN | 1 |
| Anyanwu, AC | 1 |
| Kanthi, Y | 1 |
| Robichaud, P | 1 |
| Wang, J | 1 |
| Petrovic-Djergovic, D | 1 |
| Rattan, R | 1 |
| Burant, CF | 1 |
| Pinsky, DJ | 1 |
| Baek, EB | 1 |
| Yoo, HY | 1 |
| Park, SJ | 1 |
| Kim, HS | 1 |
| Kim, SD | 1 |
| Earm, YE | 1 |
| Kim, SJ | 1 |
| Meng, F | 1 |
| To, WK | 1 |
| Gu, Y | 1 |
| Donnelly, DF | 1 |
| Mokashi, A | 1 |
| Li, J | 1 |
| Roy, A | 1 |
| Baby, SM | 1 |
| Lahiri, S | 1 |
| Bell, HJ | 1 |
| Inoue, T | 1 |
| Shum, K | 1 |
| Luk, C | 1 |
| Syed, NI | 1 |
| Bernsen, HJ | 1 |
| Rijken, PF | 1 |
| Peters, JP | 1 |
| Bakker, JH | 1 |
| Boerman, RH | 1 |
| Wesseling, P | 1 |
| van der Kogel, AJ | 1 |
| Pessina, F | 1 |
| Matteucci, G | 1 |
| Esposito, L | 1 |
| Gorelli, B | 1 |
| Valoti, M | 1 |
| Sgaragli, G | 1 |
| Leith, JT | 1 |
| Papa, G | 1 |
| Quaranto, L | 1 |
| Michelson, S | 1 |
Other Studies
11 other studies available for suramin and Hypoxia
| Article | Year |
|---|---|
Purinergic signaling is essential for full Psickle activation by hypoxia and by normoxic acid pH in mature human sickle red cells and in vitro-differentiated cultured human sickle reticulocytes.
Topics: Adenosine Triphosphate; Anemia, Sickle Cell; Apyrase; Cations; Cells, Cultured; Erythrocytes; Humans | 2022 |
Purinergic and Cholinergic Drugs Mediate Hyperventilation in Zebrafish: Evidence from a Novel Chemical Screen.
Topics: Animals; Atropine; Cholinergic Agents; Female; Gills; Hyperventilation; Hypoxia; Immunohistochemistr | 2016 |
Purinergic dysregulation in pulmonary hypertension.
Topics: Adenosine; Adenosine Triphosphate; Animals; Antigens, CD; Antihypertensive Agents; Apyrase; Arterial | 2016 |
Luminal ATP-induced contraction of rabbit pulmonary arteries and role of purinoceptors in the regulation of pulmonary arterial pressure.
Topics: Adenosine Triphosphate; Animals; Blood Pressure; Calcium Signaling; Coronary Circulation; Coronary V | 2008 |
Role of TRP channels and NCX in mediating hypoxia-induced [Ca(2+)](i) elevation in PC12 cells.
Topics: Animals; Boron Compounds; Calcium; Calcium Channel Blockers; Dose-Response Relationship, Drug; Gene | 2008 |
Nicotinic acetylcholine receptors do not mediate excitatory transmission in young rat carotid body.
Topics: Acetylcholine; Action Potentials; Analysis of Variance; Animals; Carotid Body; Chemoreceptor Cells; | 2009 |
ATP causes glomus cell [Ca2+]c increase without corresponding increases in CSN activity.
Topics: Adenosine Triphosphate; Afferent Pathways; Animals; Brain Stem; Calcium Signaling; Carotid Body; Car | 2003 |
Peripheral oxygen-sensing cells directly modulate the output of an identified respiratory central pattern generating neuron.
Topics: Action Potentials; Animals; Antinematodal Agents; Behavior, Animal; Brain; Dose-Response Relationshi | 2007 |
Suramin treatment of human glioma xenografts; effects on tumor vasculature and oxygenation status.
Topics: Animals; Antineoplastic Agents; Blood Vessels; Brain Neoplasms; Glioma; Humans; Hypoxia; Mice; Mice, | 1999 |
Protection of intrinsic nerves of guinea-pig detrusor strips against anoxia/glucopenia and reperfusion injury by taurine.
Topics: Aminoethylphosphonic Acid; Animals; Atropine; Electric Stimulation; Evoked Potentials; Glucose; Guin | 2000 |
Modification of the volumetric growth responses and steady-state hypoxic fractions of xenografted DLD-2 human colon carcinomas by administration of basic fibroblast growth factor or suramin.
Topics: Adenocarcinoma; Animals; Cell Division; Cell Line; Cell Survival; Colonic Neoplasms; Dose-Response R | 1992 |