suramin has been researched along with Hypertension, Portal in 1 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Hypertension, Portal: Abnormal increase of resistance to blood flow within the hepatic PORTAL SYSTEM, frequently seen in LIVER CIRRHOSIS and conditions with obstruction of the PORTAL VEIN.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Portal hypertension was induced by PVL (portal vein ligation) in Sprague-Dawley rats." | 1.37 | Propranolol modulates the collateral vascular responsiveness to vasopressin via a G(α)-mediated pathway in portal hypertensive rats. ( Chang, CC; Chuang, CL; Huang, HC; Huo, TI; Lee, FY; Lee, JY; Lee, SD; Lin, HC; Wang, SS, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, JY | 1 |
| Huo, TI | 1 |
| Huang, HC | 1 |
| Lee, FY | 1 |
| Lin, HC | 1 |
| Chuang, CL | 1 |
| Chang, CC | 1 |
| Wang, SS | 1 |
| Lee, SD | 1 |
1 other study available for suramin and Hypertension, Portal
| Article | Year |
|---|---|
Propranolol modulates the collateral vascular responsiveness to vasopressin via a G(α)-mediated pathway in portal hypertensive rats.
Topics: Adrenergic beta-Antagonists; Animals; Antihypertensive Agents; Arginine Vasopressin; Collateral Circ | 2011 |