suramin has been researched along with Hyperplasia in 3 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Hyperplasia: An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We described a mouse model of venous bypass graft arteriosclerosis that can be effectively retarded by locally applied suramin, a growth factor receptor antagonist." | 7.70 | Inhibition of neointima hyperplasia of mouse vein grafts by locally applied suramin. ( Dietrich, H; Hu, Y; Wick, G; Xu, Q; Zou, Y, 1999) |
| "We described a mouse model of venous bypass graft arteriosclerosis that can be effectively retarded by locally applied suramin, a growth factor receptor antagonist." | 3.70 | Inhibition of neointima hyperplasia of mouse vein grafts by locally applied suramin. ( Dietrich, H; Hu, Y; Wick, G; Xu, Q; Zou, Y, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Denda, M | 1 |
| Inoue, K | 1 |
| Fuziwara, S | 1 |
| Denda, S | 1 |
| Badache, A | 1 |
| Muja, N | 1 |
| De Vries, GH | 1 |
| Hu, Y | 1 |
| Zou, Y | 1 |
| Dietrich, H | 1 |
| Wick, G | 1 |
| Xu, Q | 1 |
3 other studies available for suramin and Hyperplasia
| Article | Year |
|---|---|
P2X purinergic receptor antagonist accelerates skin barrier repair and prevents epidermal hyperplasia induced by skin barrier disruption.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Calcium; Cells, Cultured; Epidermis; Fluores | 2002 |
Expression of Kit in neurofibromin-deficient human Schwann cells: role in Schwann cell hyperplasia associated with type 1 neurofibromatosis.
Topics: Animals; Cell Division; Glioma; Humans; Hyperplasia; Neurilemmoma; Neurofibromatosis 1; Neurofibromi | 1998 |
Inhibition of neointima hyperplasia of mouse vein grafts by locally applied suramin.
Topics: Animals; Arteriosclerosis; Carotid Arteries; Cell Movement; Enzyme Activation; Hyperplasia; Immunohi | 1999 |