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suramin and Hyperoxia

suramin has been researched along with Hyperoxia in 1 studies

Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.

Hyperoxia: An abnormal increase in the amount of oxygen in the tissues and organs.

Research Excerpts

ExcerptRelevanceReference
"Pretreatment with suramin, which binds to growth factor, results in increased EGFR tyrosine phosphorylation after stimulation, suggesting disruption of normal autocrine receptor downregulation."5.29The epidermal growth factor receptor network in type 2 pneumocytes exposed to hyperoxia in vitro. ( Frackelton, AR; Medina, M; Nici, L, 1996)
"Pretreatment with suramin, which binds to growth factor, results in increased EGFR tyrosine phosphorylation after stimulation, suggesting disruption of normal autocrine receptor downregulation."1.29The epidermal growth factor receptor network in type 2 pneumocytes exposed to hyperoxia in vitro. ( Frackelton, AR; Medina, M; Nici, L, 1996)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Nici, L1
Medina, M1
Frackelton, AR1

Other Studies

1 other study available for suramin and Hyperoxia

ArticleYear
The epidermal growth factor receptor network in type 2 pneumocytes exposed to hyperoxia in vitro.
    The American journal of physiology, 1996, Volume: 270, Issue:2 Pt 1

    Topics: Animals; Bronchoalveolar Lavage Fluid; Catechols; Cell Line; Culture Media; Epidermal Growth Factor;

1996