suramin and Hyperoxia
suramin has been researched along with Hyperoxia in 1 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Hyperoxia: An abnormal increase in the amount of oxygen in the tissues and organs.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pretreatment with suramin, which binds to growth factor, results in increased EGFR tyrosine phosphorylation after stimulation, suggesting disruption of normal autocrine receptor downregulation." | 5.29 | The epidermal growth factor receptor network in type 2 pneumocytes exposed to hyperoxia in vitro. ( Frackelton, AR; Medina, M; Nici, L, 1996) |
| "Pretreatment with suramin, which binds to growth factor, results in increased EGFR tyrosine phosphorylation after stimulation, suggesting disruption of normal autocrine receptor downregulation." | 1.29 | The epidermal growth factor receptor network in type 2 pneumocytes exposed to hyperoxia in vitro. ( Frackelton, AR; Medina, M; Nici, L, 1996) |
Research
Studies (1)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Nici, L | 1 |
| Medina, M | 1 |
| Frackelton, AR | 1 |
Other Studies
1 other study available for suramin and Hyperoxia
| Article | Year |
|---|---|
The epidermal growth factor receptor network in type 2 pneumocytes exposed to hyperoxia in vitro.
Topics: Animals; Bronchoalveolar Lavage Fluid; Catechols; Cell Line; Culture Media; Epidermal Growth Factor; | 1996 |