suramin has been researched along with Hyperglycemia in 5 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Hyperglycemia: Abnormally high BLOOD GLUCOSE level.
| Excerpt | Relevance | Reference |
|---|---|---|
| "As suramin has been reported to induce hyperglycaemia, its effect on glucose formation has been studied in isolated rabbit hepatocytes and kidney-cortex tubules." | 1.33 | Suramin-induced reciprocal changes in glucose and lactate synthesis in renal tubules contribute to its hyperglycaemic action. ( Bryła, J; Jagielski, AK; Kryśkiewicz, E, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mahapatra, MK | 1 |
| Kumar, R | 1 |
| Kumar, M | 1 |
| Trueblood, KE | 1 |
| Mohr, S | 1 |
| Dubyak, GR | 1 |
| Jagielski, AK | 1 |
| Kryśkiewicz, E | 1 |
| Bryła, J | 1 |
| Michno, A | 1 |
| Bielarczyk, H | 1 |
| Pawełczyk, T | 1 |
| Jankowska-Kulawy, A | 1 |
| Klimaszewska, J | 1 |
| Szutowicz, A | 1 |
| Lundquist, I | 1 |
5 other studies available for suramin and Hyperglycemia
| Article | Year |
|---|---|
Synthesis, biological evaluation and in silico studies of 5-(3-methoxybenzylidene)thiazolidine-2,4-dione analogues as PTP1B inhibitors.
Topics: Animals; Computer Simulation; Diabetes Mellitus; Drug Design; Enzyme Inhibitors; Humans; Hyperglycem | 2017 |
Purinergic regulation of high-glucose-induced caspase-1 activation in the rat retinal Müller cell line rMC-1.
Topics: Adenosine A2 Receptor Antagonists; Adenosine Deaminase; Adenosine-5'-(N-ethylcarboxamide); Animals; | 2011 |
Suramin-induced reciprocal changes in glucose and lactate synthesis in renal tubules contribute to its hyperglycaemic action.
Topics: Animals; Cells, Cultured; Glucose; Glycolysis; Hepatocytes; Hyperglycemia; Kidney Tubules; Lactic Ac | 2006 |
Alterations of adenine nucleotide metabolism and function of blood platelets in patients with diabetes.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Amino Acids; Blood Platelets; Diabetes Mellitus; Dose | 2007 |
Islet lysosomal enzyme activities and plasma insulin levels in obese hyperglycemic mice following injection of the lysosomotropic drug suramin.
Topics: Animals; Blood Glucose; Glucan 1,4-alpha-Glucosidase; Hyperglycemia; Injections; Insulin; Islets of | 1985 |