suramin has been researched along with Hepatocellular Carcinoma in 9 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Suramin was found to be capable of blocking HCV binding in this system at a concentration similar to that reported to be effective against dengue virus." | 1.30 | Suramin blocks hepatitis C binding to human hepatoma cells in vitro. ( Garson, JA; Grant, PR; Lubach, D; Passas, J; Whitby, K, 1999) |
| "Cell lines used were as follows: cervical cancer (HeLa), mammary cancer (MCF-7), bladder cancer (EJ), hepatoma (HuH-7, PLC/PRF/5), embryonal carcinoma (PA-1), and three in vitro transformed human fibroblast lines (KMST-6, SUSM-1, and VA-13)." | 1.28 | [Effects of suramin on cell proliferation of various types of human malignant cells]. ( Bai, LY; Miyazaki, M; Namba, M, 1991) |
| "Treatment with suramin resulted in decreases in hepatitis B surface antigen production and hepatitis B-virus associated DNA polymerase activity." | 1.27 | Effects of suramin on in vitro HBsAg production by PLC/PRF/5 cells and hepatitis B virus DNA polymerase activity. ( Benson, CA; Kessler, HA; Levin, S; Pottage, JC; Trenholme, GM, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 5 (55.56) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tayel, A | 1 |
| Abd El Galil, KH | 1 |
| Ebrahim, MA | 1 |
| Ibrahim, AS | 1 |
| El-Gayar, AM | 1 |
| Al-Gayyar, MM | 1 |
| Xu, K | 1 |
| Ren, H | 1 |
| Zhu, J | 1 |
| Yang, Y | 1 |
| Liao, F | 1 |
| Kraft, A | 1 |
| Reid, LM | 1 |
| Zvibel, I | 1 |
| Burgess, JW | 3 |
| Gould, DR | 1 |
| Marcel, YL | 3 |
| Liang, P | 1 |
| Vaidyanath, C | 1 |
| Garson, JA | 1 |
| Lubach, D | 1 |
| Passas, J | 1 |
| Whitby, K | 1 |
| Grant, PR | 1 |
| Bai, LY | 1 |
| Miyazaki, M | 1 |
| Namba, M | 1 |
| Kessler, HA | 1 |
| Pottage, JC | 1 |
| Trenholme, GM | 1 |
| Benson, CA | 1 |
| Levin, S | 1 |
9 other studies available for suramin and Hepatocellular Carcinoma
| Article | Year |
|---|---|
Suramin inhibits hepatic tissue damage in hepatocellular carcinoma through deactivation of heparanase enzyme.
Topics: Adult; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Female; Glucuronidase; Heparan Sul | 2014 |
Suramin inhibits the in vitro expression of encephalitis B virus proteins NS3 and E.
Topics: Antiviral Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Encephalitis Virus, Japanese; Humans; | 2003 |
Suramin inhibits growth and yet promotes insulin-like growth factor II expression in HepG2 cells.
Topics: Animals; Carcinoma, Hepatocellular; Cell Differentiation; Cell Division; Gene Expression; Glycosamin | 1993 |
The HepG2 extracellular matrix contains separate heparinase- and lipid-releasable pools of ApoE. Implications for hepatic lipoprotein metabolism.
Topics: Antibodies, Monoclonal; Apolipoproteins E; Carcinoma, Hepatocellular; Egtazic Acid; Emulsions; Extra | 1998 |
ApoE of the HepG2 cell surface includes a major pool associated with chondroitin sulfate proteoglycans.
Topics: Apolipoproteins E; Carcinoma, Hepatocellular; Cell Membrane; Chondroitin Sulfate Proteoglycans; Glyc | 1999 |
Suramin blocks hepatitis C binding to human hepatoma cells in vitro.
Topics: Carcinoma, Hepatocellular; Chloroform; Culture Media; Hepacivirus; Humans; Polysaccharides; Sulfates | 1999 |
Dynamic and stable pools of apoE differ functionally at the HepG2 cell surface.
Topics: Apolipoproteins E; Binding Sites; Brefeldin A; Carcinoma, Hepatocellular; Cell Membrane; Chondroitin | 2001 |
[Effects of suramin on cell proliferation of various types of human malignant cells].
Topics: Breast Neoplasms; Carcinoma, Hepatocellular; Cell Division; Female; Humans; Liver Neoplasms; Male; S | 1991 |
Effects of suramin on in vitro HBsAg production by PLC/PRF/5 cells and hepatitis B virus DNA polymerase activity.
Topics: Carcinoma, Hepatocellular; Cell Line; Cells, Cultured; DNA-Directed DNA Polymerase; Dose-Response Re | 1986 |