suramin has been researched along with Hepatitis B in 5 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Hepatitis B: INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Suramin has recently been shown to inhibit the activity of the duck hepatitis B virus DNA polymerase (DHBV DNAp) in vitro." | 7.67 | Suramin treatment for chronic active hepatitis B--toxic and ineffective. ( Anderson, MG; Coleman, JC; Loke, RH; Murray-Lyon, IM; Tsiquaye, KN; Zuckerman, AJ, 1987) |
| "Suramin, a polybasic anion, blocks the activity of the DNA polymerase encoded by the duck hepatitis B virus." | 7.67 | Suramin inhibits duck hepatitis B virus DNA polymerase activity. ( Tsiquaye, K; Zuckerman, A, 1985) |
| "Suramin has recently been shown to inhibit the activity of the duck hepatitis B virus DNA polymerase (DHBV DNAp) in vitro." | 3.67 | Suramin treatment for chronic active hepatitis B--toxic and ineffective. ( Anderson, MG; Coleman, JC; Loke, RH; Murray-Lyon, IM; Tsiquaye, KN; Zuckerman, AJ, 1987) |
| "Acyclovir and suramin were examined for their efficacy alone and in combination against duck hepatitis B virus (DHBV) in persistently infected Pekin ducks." | 3.67 | Antiviral activity of the polybasic anion, suramin and acyclovir in Hepadna virus infection. ( Collins, P; Tsiquaye, KN; Zuckerman, AJ, 1986) |
| "Suramin, a polybasic anion, blocks the activity of the DNA polymerase encoded by the duck hepatitis B virus." | 3.67 | Suramin inhibits duck hepatitis B virus DNA polymerase activity. ( Tsiquaye, K; Zuckerman, A, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (80.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Enomoto, M | 1 |
| Sawano, Y | 1 |
| Kosuge, S | 1 |
| Yamano, Y | 1 |
| Kuroki, K | 1 |
| Ohtsuki, K | 1 |
| Tsiquaye, KN | 3 |
| Collins, P | 2 |
| Zuckerman, AJ | 3 |
| Loke, RH | 1 |
| Anderson, MG | 1 |
| Coleman, JC | 1 |
| Murray-Lyon, IM | 1 |
| Tsiquaye, K | 1 |
| Zuckerman, A | 1 |
5 other studies available for suramin and Hepatitis B
| Article | Year |
|---|---|
High phosphorylation of HBV core protein by two alpha-type CK2-activated cAMP-dependent protein kinases in vitro.
Topics: Animals; Antineoplastic Agents; Casein Kinase II; Cattle; Cyclic AMP; Cyclic AMP-Dependent Protein K | 2006 |
Screening of antiviral drugs for treatment of hepatitis B.
Topics: Acyclovir; Animals; Antiviral Agents; Drug Evaluation, Preclinical; Ducks; Foscarnet; Hepatitis B; H | 1986 |
Suramin treatment for chronic active hepatitis B--toxic and ineffective.
Topics: Esophageal and Gastric Varices; Gastrointestinal Hemorrhage; Hepatic Encephalopathy; Hepatitis B; He | 1987 |
Antiviral activity of the polybasic anion, suramin and acyclovir in Hepadna virus infection.
Topics: Acyclovir; Animals; Drug Therapy, Combination; Ducks; Hepatitis B; Hepatitis B virus; Hepatitis, Ani | 1986 |
Suramin inhibits duck hepatitis B virus DNA polymerase activity.
Topics: Animals; Blood Proteins; Dose-Response Relationship, Drug; Ducks; Female; Hepatitis B; Hepatitis B v | 1985 |