suramin has been researched along with Hepatitis, Chronic in 1 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Hepatitis, Chronic: INFLAMMATION of the LIVER with ongoing hepatocellular injury for 6 months or more, characterized by NECROSIS of HEPATOCYTES and inflammatory cell (LEUKOCYTES) infiltration. Chronic hepatitis can be caused by viruses, medications, autoimmune diseases, and other unknown factors.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Suramin has recently been shown to inhibit the activity of the duck hepatitis B virus DNA polymerase (DHBV DNAp) in vitro." | 7.67 | Suramin treatment for chronic active hepatitis B--toxic and ineffective. ( Anderson, MG; Coleman, JC; Loke, RH; Murray-Lyon, IM; Tsiquaye, KN; Zuckerman, AJ, 1987) |
| "Suramin has recently been shown to inhibit the activity of the duck hepatitis B virus DNA polymerase (DHBV DNAp) in vitro." | 3.67 | Suramin treatment for chronic active hepatitis B--toxic and ineffective. ( Anderson, MG; Coleman, JC; Loke, RH; Murray-Lyon, IM; Tsiquaye, KN; Zuckerman, AJ, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Loke, RH | 1 |
| Anderson, MG | 1 |
| Coleman, JC | 1 |
| Tsiquaye, KN | 1 |
| Zuckerman, AJ | 1 |
| Murray-Lyon, IM | 1 |
1 other study available for suramin and Hepatitis, Chronic
| Article | Year |
|---|---|
Suramin treatment for chronic active hepatitis B--toxic and ineffective.
Topics: Esophageal and Gastric Varices; Gastrointestinal Hemorrhage; Hepatic Encephalopathy; Hepatitis B; He | 1987 |