suramin has been researched along with Hemolysis in 12 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Hemolysis: The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.
| Excerpt | Relevance | Reference |
|---|---|---|
| " One such compound, suramin, was shown to be an effective inhibitor of PCA and the proteinuria manifestation of EGN while not affecting antibody fixation to tissue or histamine-mediated skin reaction." | 3.66 | Inhibition of immune complex-mediated activation of complement. Effects of agents modulating activation of, and the activated C1 complex. ( Fletcher, DS; Lin, TY, 1980) |
| "Suramin did not inhibit fibrin degradation by the fibrinolytic system in plasma." | 1.25 | Effects of suramin on complement, blood clotting, fibrinolysis and kinin formation. ( Eisen, V; Loveday, C, 1973) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (58.33) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 2 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Arvidsson, I | 1 |
| Ståhl, AL | 1 |
| Hedström, MM | 1 |
| Kristoffersson, AC | 1 |
| Rylander, C | 1 |
| Westman, JS | 1 |
| Storry, JR | 1 |
| Olsson, ML | 1 |
| Karpman, D | 1 |
| Chaves-Moreira, D | 1 |
| de Moraes, FR | 1 |
| Caruso, ÍP | 1 |
| Chaim, OM | 1 |
| Senff-Ribeiro, A | 1 |
| Ullah, A | 1 |
| da Silva, LS | 1 |
| Chahine, J | 1 |
| Arni, RK | 1 |
| Veiga, SS | 1 |
| MANSKI, W | 1 |
| ZYLBERBERG, A | 1 |
| Jack, RM | 1 |
| Ward, PA | 1 |
| Fletcher, DS | 1 |
| Lin, TY | 1 |
| Zhang, H | 1 |
| Weir, B | 2 |
| Marton, LS | 2 |
| Macdonald, RL | 1 |
| Bindokas, V | 1 |
| Miller, RJ | 1 |
| Brorson, JR | 1 |
| Sima, B | 1 |
| Macdonald, L | 1 |
| Zhang, J | 1 |
| Light, DB | 1 |
| Dahlstrom, PK | 1 |
| Gronau, RT | 1 |
| Baumann, NL | 1 |
| Schmid, JH | 1 |
| Lachmann, PJ | 1 |
| Nicol, P | 1 |
| Aston, WP | 1 |
| Eisen, V | 1 |
| Loveday, C | 1 |
| Rommel, FA | 1 |
| Stolfi, R | 1 |
12 other studies available for suramin and Hemolysis
| Article | Year |
|---|---|
Shiga toxin-induced complement-mediated hemolysis and release of complement-coated red blood cell-derived microvesicles in hemolytic uremic syndrome.
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Child; Child, Preschool; Coated Vesicles; Complement | 2015 |
Potential Implications for Designing Drugs Against the Brown Spider Venom Phospholipase-D.
Topics: Animals; Arthropod Proteins; Benzimidazoles; Brown Recluse Spider; Drug Design; Drug Evaluation, Pre | 2017 |
[Inactivation of the 3d component of complement & the hemolytic processes in vivo].
Topics: Complement System Proteins; Dextrans; Hemolysis; Humans; Suramin | 1958 |
The role in vivo of C3 and the C3b receptor in babesial infection in the rat.
Topics: Animals; Babesiosis; Complement C3; Complement C3b; Coombs Test; Elapid Venoms; Erythrocytes; Hemoly | 1980 |
Inhibition of immune complex-mediated activation of complement. Effects of agents modulating activation of, and the activated C1 complex.
Topics: Animals; Antigen-Antibody Complex; Complement Activating Enzymes; Complement Activation; Complement | 1980 |
Mechanisms of hemolysate-induced [Ca2+]i elevation in cerebral smooth muscle cells.
Topics: 2,3-Diphosphoglycerate; Animals; Basilar Artery; Calcium; Calcium Channel Blockers; Cytosol; Diphosp | 1995 |
Effect of P2-purinoceptor antagonists on hemolysate-induced and adenosine 5'-triphosphate-induced contractions of dog basilar artery in vitro.
Topics: Adenosine Triphosphate; Animals; Basilar Artery; Dogs; Female; Hemolysis; Ischemic Attack, Transient | 1996 |
Extracellular ATP activates a P2 receptor in necturus erythrocytes during hypotonic swelling.
Topics: Adenosine; Adenosine Triphosphate; Animals; Cell Size; Erythrocytes; Gramicidin; Hemolysis; Necturus | 2001 |
[Paroxysmal nocturnal hemoglobinuria: inhibition of in vitro hemolysis by germanin, heparin and heparinoids].
Topics: Complement System Proteins; Hemoglobinuria, Paroxysmal; Hemolysis; Heparin; Heparinoids; Humans; Pho | 1966 |
Further studies on the C3b inactivator or conglutinogen activating factor (KAF).
Topics: Animals; Binding Sites; Blood Proteins; Cattle; Chemical Precipitation; Chromatography, DEAE-Cellulo | 1973 |
Effects of suramin on complement, blood clotting, fibrinolysis and kinin formation.
Topics: Animals; Blood Coagulation; Complement Inactivator Proteins; Cryoglobulins; Erythrocytes; Esterases; | 1973 |
Preparation and partial characterization of sheep erythrocyte-antibody-complement intermediate.
Topics: Animals; Antibodies; Binding Sites; Chromatography, Ion Exchange; Complement System Proteins; Erythr | 1968 |