Page last updated: 2024-11-04

suramin and HIV

suramin has been researched along with HIV in 18 studies

Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.

HIV: Human immunodeficiency virus. A non-taxonomic and historical term referring to any of two species, specifically HIV-1 and/or HIV-2. Prior to 1986, this was called human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV). From 1986-1990, it was an official species called HIV. Since 1991, HIV was no longer considered an official species name; the two species were designated HIV-1 and HIV-2.

Research Excerpts

ExcerptRelevanceReference
"Suramin is a toxic agent that shows no virologic, immunologic, or clinical benefit in patients with HIV-related disease."6.66Lack of response to suramin in patients with AIDS and AIDS-related complex. ( Abrams, DI; Feorino, P; Gottlieb, MS; Kaplan, LD; Kaufman, L; Kiprov, D; Levy, JA; Volberding, PA; Wolfe, PR; Wong, R, 1987)
"Ten homosexual men with the acquired immunodeficiency syndrome were included in a serologic follow-up study (duration, 40 weeks) of human immunodeficiency virus (HIV) antigenemia."5.27Persistence of human immunodeficiency virus antigenemia in patients with the acquired immunodeficiency syndrome treated with a reverse transcriptase inhibitor, suramin. Ten-patient case-control study. ( Danner, SA; Eeftinck Schattenkerk, JK; Goudsmit, J; Lange, JM; Miedema, F; Paul, DA; Schellekens, PT; van Boxtel, CJ, 1988)
"The inhibitory activities of human immunodeficiency virus reverse transcriptase (HIV-RT) inhibitors PFA and Suramin against HIV-RT and equine infectious anemic virus reverse transcriptase (EIAV-RT) were studied in this paper."3.69Screening anti-HIV Chinese materia medica with HIV and equine infectious anemic virus reverse transcriptase. ( Chen, H; Quan, K; Sun, M; Tang, X; Zhang, X, 1994)
"Suramin sodium is a reverse transcriptase inhibitor with in vitro activity against the human immunodeficiency virus (HIV), the causative agent of acquired immunodeficiency syndrome (AIDS)."3.67Suramin therapy in AIDS and related disorders. Report of the US Suramin Working Group. ( Cheson, BD; Gill, P; Groopman, JE; Kaplan, LD; Levine, AM; Mildvan, D; Poiesz, BJ; Rios, A; Volberding, PA; Wolfe, P, 1987)
"Suramin is a toxic agent that shows no virologic, immunologic, or clinical benefit in patients with HIV-related disease."2.66Lack of response to suramin in patients with AIDS and AIDS-related complex. ( Abrams, DI; Feorino, P; Gottlieb, MS; Kaplan, LD; Kaufman, L; Kiprov, D; Levy, JA; Volberding, PA; Wolfe, PR; Wong, R, 1987)
"Human African trypanosomiasis (HAT), otherwise known as sleeping sickness, has remained a disease with no effective treatment."2.42Arsenicals (melarsoprol), pentamidine and suramin in the treatment of human African trypanosomiasis. ( Nok, AJ, 2003)
"Suramin is a potent inhibitor of the reverse transcriptase (RNA-directed DNA polymerase) of retroviruses, including the HTLV-III/LAV (human T-cell lymphotropic virus type III/lymphadenopathy-associated virus) reverse transcriptase."2.37Suramin in the treatment of AIDS: mechanism of action. ( De Clercq, E, 1987)
"Ten homosexual men with the acquired immunodeficiency syndrome were included in a serologic follow-up study (duration, 40 weeks) of human immunodeficiency virus (HIV) antigenemia."1.27Persistence of human immunodeficiency virus antigenemia in patients with the acquired immunodeficiency syndrome treated with a reverse transcriptase inhibitor, suramin. Ten-patient case-control study. ( Danner, SA; Eeftinck Schattenkerk, JK; Goudsmit, J; Lange, JM; Miedema, F; Paul, DA; Schellekens, PT; van Boxtel, CJ, 1988)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-199011 (61.11)18.7374
1990's5 (27.78)18.2507
2000's1 (5.56)29.6817
2010's0 (0.00)24.3611
2020's1 (5.56)2.80

Authors

AuthorsStudies
De Clercq, E4
Nok, AJ1
Tang, X1
Chen, H1
Zhang, X1
Quan, K1
Sun, M1
Neyts, J1
Gabriel, JL1
Mitchell, WM1
Bhat, S1
Otsuka, T1
Srinivasan, A1
Mahoney, CW1
Azzi, A1
Huang, KP1
Vogt, M1
Schooley, RT1
Hirsch, MS1
Nakashima, H1
Harada, S1
Yamamoto, N1
Eeftinck Schattenkerk, JK1
Danner, SA1
Lange, JM1
Paul, DA1
van Boxtel, CJ1
Miedema, F1
Schellekens, PT1
Goudsmit, J1
Mitsuya, H1
Looney, DJ1
Kuno, S1
Ueno, R1
Wong-Staal, F1
Broder, S2
Yarchoan, R1
Weber, J1
Kaplan, LD2
Wolfe, PR1
Volberding, PA2
Feorino, P1
Levy, JA1
Abrams, DI1
Kiprov, D1
Wong, R1
Kaufman, L1
Gottlieb, MS1
Resnick, L1
Markham, PD1
Veren, K1
Salahuddin, SZ1
Gallo, RC1
Cheson, BD1
Levine, AM1
Mildvan, D1
Wolfe, P1
Rios, A1
Groopman, JE1
Gill, P1
Poiesz, BJ1

Reviews

4 reviews available for suramin and HIV

ArticleYear
Arsenicals (melarsoprol), pentamidine and suramin in the treatment of human African trypanosomiasis.
    Parasitology research, 2003, Volume: 90, Issue:1

    Topics: Animals; Drug Resistance; HIV; Humans; Melarsoprol; Pentamidine; Suramin; Trypanocidal Agents; Trypa

2003
Suramin in the treatment of AIDS: mechanism of action.
    Antiviral research, 1987, Volume: 7, Issue:1

    Topics: Acquired Immunodeficiency Syndrome; Cytopathogenic Effect, Viral; HIV; Humans; Reverse Transcriptase

1987
Progress in the development of antiviral therapy for HTLV-III-associated diseases.
    Important advances in oncology, 1987

    Topics: Acquired Immunodeficiency Syndrome; Antimony; Antiviral Agents; Foscarnet; HIV; Humans; Phosphonoace

1987
Perspectives for the chemotherapy of AIDS.
    Chemioterapia : international journal of the Mediterranean Society of Chemotherapy, 1988, Volume: 7, Issue:6

    Topics: Acquired Immunodeficiency Syndrome; Glycyrrhetinic Acid; Glycyrrhizic Acid; HIV; Humans; Polysacchar

1988

Trials

2 trials available for suramin and HIV

ArticleYear
[Chemotherapy and immunoprophylaxis of HIV infection].
    Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1986, Nov-25, Volume: 75, Issue:48

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Clinical Trials as Topic; Foscarnet; HIV; Huma

1986
Lack of response to suramin in patients with AIDS and AIDS-related complex.
    The American journal of medicine, 1987, Mar-23, Volume: 82, Issue:3 Spec No

    Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Complex; Clinical Trials as Topic; Drug Admi

1987

Other Studies

12 other studies available for suramin and HIV

ArticleYear
1984-Discovery of the First Anti-HIV Drug, Suramin.
    Viruses, 2021, 08-19, Volume: 13, Issue:8

    Topics: Acquired Immunodeficiency Syndrome; Anti-HIV Agents; Drug Discovery; History, 20th Century; History,

2021
Screening anti-HIV Chinese materia medica with HIV and equine infectious anemic virus reverse transcriptase.
    Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 1994, Volume: 14, Issue:1

    Topics: Animals; Antiviral Agents; Drug Evaluation, Preclinical; Drugs, Chinese Herbal; HIV; HIV Reverse Tra

1994
Effect of polyanionic compounds on intracutaneous and intravaginal herpesvirus infection in mice: impact on the search for vaginal microbicides with anti-HIV activity.
    Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association, 1995, Sep-01, Volume: 10, Issue:1

    Topics: Acrylic Resins; Animals; Antiviral Agents; Dextran Sulfate; Drug Evaluation, Preclinical; Female; He

1995
Functional design of potential inhibitors of human immunodeficiency virus (HIV) binding to CD4+ target cells: a molecular model of gp120 predicts ligand binding.
    Drug design and discovery, 1996, Volume: 14, Issue:2

    Topics: Aurintricarboxylic Acid; Binding Sites; CD4 Antigens; Computer Simulation; Drug Design; HIV; HIV Env

1996
Inhibition of gp120 binding to galactosyl ceramide and sulfatide by potential anti-HIV compounds.
    AIDS (London, England), 1992, Volume: 6, Issue:10

    Topics: Antiviral Agents; Drug Evaluation, Preclinical; Galactosylceramides; HIV; HIV Envelope Protein gp120

1992
Effects of suramin, an anti-human immunodeficiency virus reverse transcriptase agent, on protein kinase C. Differential activation and inhibition of protein kinase C isozymes.
    The Journal of biological chemistry, 1990, Apr-05, Volume: 265, Issue:10

    Topics: Adenosine Triphosphate; Animals; Binding, Competitive; Brain; Calcium; Diglycerides; Enzyme Activati

1990
Effect of retinoic acid on the replication of human immunodeficiency virus in HTLV-I-positive MT-4 cells.
    Medical microbiology and immunology, 1987, Volume: 176, Issue:4

    Topics: Cell Line; Deltaretrovirus; HIV; Reverse Transcriptase Inhibitors; Suramin; Tretinoin; Viral Plaque

1987
Persistence of human immunodeficiency virus antigenemia in patients with the acquired immunodeficiency syndrome treated with a reverse transcriptase inhibitor, suramin. Ten-patient case-control study.
    Archives of internal medicine, 1988, Volume: 148, Issue:1

    Topics: Acquired Immunodeficiency Syndrome; Adult; Antigens, Viral; HIV; HIV Antigens; Humans; Lymphocytes;

1988
Dextran sulfate suppression of viruses in the HIV family: inhibition of virion binding to CD4+ cells.
    Science (New York, N.Y.), 1988, Apr-29, Volume: 240, Issue:4852

    Topics: Antigens, Differentiation, T-Lymphocyte; Cell Line; Dextran Sulfate; Dextrans; Dideoxynucleosides; D

1988
AIDS: the virus, antivirals and vaccines.
    British journal of hospital medicine, 1987, Volume: 37, Issue:2

    Topics: Acquired Immunodeficiency Syndrome; Antimony; Antiviral Agents; Foscarnet; Genes, Viral; HIV; Humans

1987
In vitro suppression of HTLV-III/LAV infectivity by a combination of acyclovir and suramin.
    The Journal of infectious diseases, 1986, Volume: 154, Issue:6

    Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Dose-Response Relationship, Drug; Drug Synergism; HIV

1986
Suramin therapy in AIDS and related disorders. Report of the US Suramin Working Group.
    JAMA, 1987, Sep-11, Volume: 258, Issue:10

    Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Complex; Drug Evaluation; Female; HIV; Human

1987