Page last updated: 2024-11-04

suramin and Glioma

suramin has been researched along with Glioma in 27 studies

Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.

Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)

Research Excerpts

ExcerptRelevanceReference
"To determine the toxicity, efficacy, and pharmacology of suramin in patients with recurrent or progressive recurrent high-grade gliomas."9.09Toxicity, efficacy, and pharmacology of suramin in adults with recurrent high-grade gliomas. ( Fisher, J; Grochow, LB; Grossman, SA; Lesser, G; Phuphanich, S; Piantadosi, S; Rozental, J, 2001)
" The aim of the study was to investigate the effect of suramin on the telomerase activity of C6 glioma cells and on the growth of C6 glioma spheroids."7.74The inhibitory effect of suramin on telomerase activity and spheroid growth of C6 glioma cells. ( Akev, N; Bilir, A; Erguven, M; Karabulut, E; Ozdemir, A, 2008)
"We have recently shown that glioma cell lines, as well as cells of human malignant gliomas in situ, synthesize tropoelastin."7.70Cell surface aggregation of elastin receptor molecules caused by suramin amplified signals leading to proliferation of human glioma cells. ( Hinek, A; Jung, S; Rutka, JT, 1999)
"In this study the effect of suramin on tumor growth, vascularity and oxygenation of a human glioma xenografted in the nude mouse was examined."7.70Suramin treatment of human glioma xenografts; effects on tumor vasculature and oxygenation status. ( Bakker, JH; Bernsen, HJ; Boerman, RH; Peters, JP; Rijken, PF; van der Kogel, AJ; Wesseling, P, 1999)
"The antiestrogen tamoxifen is commonly used to treat breast cancer, but it also has therapeutic activity in several other types of cancer."7.70Tamoxifen-induced enhancement of calcium signaling in glioma and MCF-7 breast cancer cells. ( Couldwell, WT; Lin, JH; Nedergaard, M; Song, H; Takano, T; Zhang, W, 2000)
" Additionally, we compared the antitumoral effect of protamine with that of another inhibitor of angiogenesis, suramin, and investigated a potential synergistic antitumoral action of low doses of protamine combined with the antineoplastic carmustine."5.30Protamine inhibits angiogenesis and growth of C6 rat glioma; a synergistic effect when combined with carmustine. ( Arrieta, O; Guevara, P; Ortiz, A; Rembao, D; Reyes, S; Sotelo, J, 1998)
"Suramin is a novel anticancer agent that blocks the binding of growth factors, including basic fibroblast growth factor (bFGF), to their receptors."5.29Suramin inhibits glioma cell proliferation in vitro and in the brain. ( Brem, S; Engelhard, H; Gately, S; Takano, S; Tsanaclis, AM, 1994)
"To determine the toxicity, efficacy, and pharmacology of suramin in patients with recurrent or progressive recurrent high-grade gliomas."5.09Toxicity, efficacy, and pharmacology of suramin in adults with recurrent high-grade gliomas. ( Fisher, J; Grochow, LB; Grossman, SA; Lesser, G; Phuphanich, S; Piantadosi, S; Rozental, J, 2001)
" The aim of the study was to investigate the effect of suramin on the telomerase activity of C6 glioma cells and on the growth of C6 glioma spheroids."3.74The inhibitory effect of suramin on telomerase activity and spheroid growth of C6 glioma cells. ( Akev, N; Bilir, A; Erguven, M; Karabulut, E; Ozdemir, A, 2008)
"We have recently shown that glioma cell lines, as well as cells of human malignant gliomas in situ, synthesize tropoelastin."3.70Cell surface aggregation of elastin receptor molecules caused by suramin amplified signals leading to proliferation of human glioma cells. ( Hinek, A; Jung, S; Rutka, JT, 1999)
"In this study the effect of suramin on tumor growth, vascularity and oxygenation of a human glioma xenografted in the nude mouse was examined."3.70Suramin treatment of human glioma xenografts; effects on tumor vasculature and oxygenation status. ( Bakker, JH; Bernsen, HJ; Boerman, RH; Peters, JP; Rijken, PF; van der Kogel, AJ; Wesseling, P, 1999)
"The antiestrogen tamoxifen is commonly used to treat breast cancer, but it also has therapeutic activity in several other types of cancer."3.70Tamoxifen-induced enhancement of calcium signaling in glioma and MCF-7 breast cancer cells. ( Couldwell, WT; Lin, JH; Nedergaard, M; Song, H; Takano, T; Zhang, W, 2000)
"The mechanism by which cyclic GMP synthesis is activated through a nucleotide receptor was studied in mouse neuroblastoma x rat glioma hybrid cells [108CC15 (NG 108-15)]."3.69Ca(2+)- and nitric oxide-dependent stimulation of cyclic GMP synthesis in neuronal cell line induced by P2-purinergic/pyrimidinergic receptor. ( Reiser, G, 1995)
" Additionally, we compared the antitumoral effect of protamine with that of another inhibitor of angiogenesis, suramin, and investigated a potential synergistic antitumoral action of low doses of protamine combined with the antineoplastic carmustine."1.30Protamine inhibits angiogenesis and growth of C6 rat glioma; a synergistic effect when combined with carmustine. ( Arrieta, O; Guevara, P; Ortiz, A; Rembao, D; Reyes, S; Sotelo, J, 1998)
"Suramin is a novel anticancer agent that blocks the binding of growth factors, including basic fibroblast growth factor (bFGF), to their receptors."1.29Suramin inhibits glioma cell proliferation in vitro and in the brain. ( Brem, S; Engelhard, H; Gately, S; Takano, S; Tsanaclis, AM, 1994)
"Suramin is a competitive antagonist for the nucleotide receptor; reactive blue and DIDS are more selective antagonists for the P2Y receptor."1.29Different signal transduction pathways are coupled to the nucleotide receptor and the P2Y receptor in C6 glioma cells. ( Chuang, DM; Lin, WW, 1994)
"Suramin treatment induced a 2-fold increase in immunoreactive FGFR and a 1."1.29Basic fibroblast growth factor binding and processing by human glioma cells. ( Knee, RS; Murphy, PR, 1995)
"Suramin is an anti-helminthic drug that has been shown to antagonize the effects of a variety of growth factors including EGF, PDGF and TGF beta."1.28[Suramin inhibits the proliferation and stimulates the differentiation of tumoral cell lines HT29-D4 and C6]. ( Baghdiguian, S; Fantini, J; Marvaldi, J; Pichon, J, 1991)
"Suramin is a polyanionic compound currently used under evaluation for antineoplastic activity."1.28Double screening of suramin derivatives on human colon cancer cells and on neural cells provides new therapeutic agents with reduced toxicity. ( Baghdiguian, S; Fantini, J; Nickel, P, 1991)

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's21 (77.78)18.2507
2000's6 (22.22)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Erguven, M1
Akev, N1
Ozdemir, A1
Karabulut, E1
Bilir, A1
Bellinzona, M1
Roser, F1
Matthies, C1
Samii, M1
Saini, M1
Takano, S2
Coomber, BL1
Gately, S1
Engelhard, H1
Tsanaclis, AM1
Brem, S1
Reiser, G1
Boyer, JL1
Zohn, IE1
Jacobson, KA1
Harden, TK1
Lin, WW2
Chuang, DM1
Westphal, M2
Hamel, W1
Zirkel, D1
Herrmann, HD2
Bilzer, T1
Reifenberger, G1
Schober, R1
Wechsler, W1
Albert, FK1
Behnke, J1
Chen, ZP1
Krull, N1
Xu, S1
Levy, A1
Lightman, SL1
Murphy, PR1
Knee, RS1
Chen, BC1
Lee, CM1
Johnson, JP1
Bruce, JN1
Nagai, G1
Nakaoka, Y1
Badache, A1
Muja, N1
De Vries, GH1
Arrieta, O1
Guevara, P1
Reyes, S1
Ortiz, A1
Rembao, D1
Sotelo, J1
Hinek, A1
Jung, S1
Rutka, JT1
Bernsen, HJ1
Rijken, PF1
Peters, JP1
Bakker, JH1
Boerman, RH1
Wesseling, P1
van der Kogel, AJ1
Zhang, W1
Couldwell, WT1
Song, H1
Takano, T1
Lin, JH1
Nedergaard, M1
Grossman, SA1
Phuphanich, S1
Lesser, G1
Rozental, J1
Grochow, LB1
Fisher, J1
Piantadosi, S1
Meyer, RG1
Küpper, JH1
Kandolf, R1
Rodemann, HP1
Ackermann, E1
Hoppe, J1
Baghdiguian, S2
Pichon, J1
Marvaldi, J3
Fantini, J4
Nickel, P1
Guo, XJ2
Rougon, G2
Roubin, R1
Kuratsu, J1
Ushio, Y1

Reviews

2 reviews available for suramin and Glioma

ArticleYear
[Anti-angiogenesis treatment for brain tumors--present and future].
    Nihon rinsho. Japanese journal of clinical medicine, 2005, Volume: 63 Suppl 9

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Bevacizumab; Brain Neoplasms; Clinical Tr

2005
Angiogenesis in human gliomas: prognostic and therapeutic implications.
    EXS, 1997, Volume: 79

    Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cyclohexanes; Endothelial Growth Factors; Epidermal

1997

Trials

2 trials available for suramin and Glioma

ArticleYear
Epidermal growth factor receptor expression in human malignant glioma: in vitro and in vivo effects of application of monoclonal antibodies to the epidermal growth factor receptor.
    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1994, Volume: 135

    Topics: Antibodies, Monoclonal; Antibodies, Neoplasm; Brain Neoplasms; Cell Division; Epidermal Growth Facto

1994
Toxicity, efficacy, and pharmacology of suramin in adults with recurrent high-grade gliomas.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2001, Jul-01, Volume: 19, Issue:13

    Topics: Adult; Aged; Antineoplastic Agents; Central Nervous System Neoplasms; Female; Glioma; Humans; Male;

2001

Other Studies

23 other studies available for suramin and Glioma

ArticleYear
The inhibitory effect of suramin on telomerase activity and spheroid growth of C6 glioma cells.
    Medical science monitor : international medical journal of experimental and clinical research, 2008, Volume: 14, Issue:8

    Topics: Animals; Bromodeoxyuridine; Cell Cycle; Cell Nucleolus; Cell Proliferation; DNA, Neoplasm; Glioma; R

2008
Biopolymer-mediated suramin chemotherapy in the treatment of experimental brain tumours.
    Acta oncologica (Stockholm, Sweden), 2004, Volume: 43, Issue:3

    Topics: Animals; Antineoplastic Agents; Biopolymers; Brain Neoplasms; Drug Implants; Drug Screening Assays,

2004
Suramin inhibits C6 glioma-induced angiogenesis in vitro.
    Journal of cellular biochemistry, 1995, Volume: 58, Issue:2

    Topics: Analysis of Variance; Animals; Cattle; Cell Division; Chemotaxis; Culture Media, Conditioned; Cultur

1995
Suramin inhibits glioma cell proliferation in vitro and in the brain.
    Journal of neuro-oncology, 1994, Volume: 21, Issue:3

    Topics: Animals; Brain Neoplasms; Cell Division; Dose-Response Relationship, Drug; Drug Screening Assays, An

1994
Ca(2+)- and nitric oxide-dependent stimulation of cyclic GMP synthesis in neuronal cell line induced by P2-purinergic/pyrimidinergic receptor.
    Journal of neurochemistry, 1995, Volume: 64, Issue:1

    Topics: Adenosine Triphosphate; Aminoquinolines; Animals; Bradykinin; Calcium; Colforsin; Cyclic GMP; Glioma

1995
Differential effects of P2-purinoceptor antagonists on phospholipase C- and adenylyl cyclase-coupled P2Y-purinoceptors.
    British journal of pharmacology, 1994, Volume: 113, Issue:2

    Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Cells, Cultured; Erythrocyte Membrane; Glio

1994
Different signal transduction pathways are coupled to the nucleotide receptor and the P2Y receptor in C6 glioma cells.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 269, Issue:3

    Topics: Adenylate Cyclase Toxin; Animals; Cyclic AMP; Glioma; Nucleotides; Pertussis Toxin; Phosphatidylinos

1994
Molecular cloning and functional characterization of a rat pituitary G protein-coupled adenosine triphosphate (ATP) receptor.
    Endocrinology, 1996, Volume: 137, Issue:5

    Topics: Adenosine Triphosphate; Amino Acid Sequence; Animals; Base Sequence; Blotting, Southern; Calcium; Cl

1996
Basic fibroblast growth factor binding and processing by human glioma cells.
    Molecular and cellular endocrinology, 1995, Oct-30, Volume: 114, Issue:1-2

    Topics: Animals; Base Sequence; Binding Sites; Cattle; Cross-Linking Reagents; DNA Primers; Fibroblast Growt

1995
Inhibition of ecto-ATPase by PPADS, suramin and reactive blue in endothelial cells, C6 glioma cells and RAW 264.7 macrophages.
    British journal of pharmacology, 1996, Volume: 119, Issue:8

    Topics: Adenosine Triphosphatases; Animals; Brain Neoplasms; Cell Line; Endothelium, Vascular; Enzyme Inhibi

1996
Cooling sensitive [Ca2+]i response associated with signaling of G protein-coupled receptors.
    Biochemical and biophysical research communications, 1998, Jul-30, Volume: 248, Issue:3

    Topics: Adenosine Triphosphate; Aniline Compounds; Animals; Calcium; Calcium-Transporting ATPases; Cold Temp

1998
Expression of Kit in neurofibromin-deficient human Schwann cells: role in Schwann cell hyperplasia associated with type 1 neurofibromatosis.
    Oncogene, 1998, Aug-13, Volume: 17, Issue:6

    Topics: Animals; Cell Division; Glioma; Humans; Hyperplasia; Neurilemmoma; Neurofibromatosis 1; Neurofibromi

1998
Protamine inhibits angiogenesis and growth of C6 rat glioma; a synergistic effect when combined with carmustine.
    European journal of cancer (Oxford, England : 1990), 1998, Volume: 34, Issue:13

    Topics: Animals; Antineoplastic Agents, Alkylating; Carmustine; Cell Division; Dose-Response Relationship, D

1998
Cell surface aggregation of elastin receptor molecules caused by suramin amplified signals leading to proliferation of human glioma cells.
    Acta neuropathologica, 1999, Volume: 97, Issue:4

    Topics: Cell Division; Culture Media, Serum-Free; Cyclin-Dependent Kinases; Cyclins; Dose-Response Relations

1999
Suramin treatment of human glioma xenografts; effects on tumor vasculature and oxygenation status.
    Journal of neuro-oncology, 1999, Volume: 44, Issue:2

    Topics: Animals; Antineoplastic Agents; Blood Vessels; Brain Neoplasms; Glioma; Humans; Hypoxia; Mice; Mice,

1999
Tamoxifen-induced enhancement of calcium signaling in glioma and MCF-7 breast cancer cells.
    Cancer research, 2000, Oct-01, Volume: 60, Issue:19

    Topics: Adenosine Triphosphate; Adult; Animals; Antineoplastic Agents, Hormonal; Astrocytes; Breast Neoplasm

2000
Early growth response-1 gene (Egr-1) promoter induction by ionizing radiation in U87 malignant glioma cells in vitro.
    European journal of biochemistry, 2002, Volume: 269, Issue:1

    Topics: Androstadienes; Anisomycin; Blotting, Western; Colforsin; DNA-Binding Proteins; Early Growth Respons

2002
Receptors for platelet derived growth factor in human glioma cell lines and influence of suramin on cell proliferation.
    Journal of neuro-oncology, 1991, Volume: 11, Issue:3

    Topics: Brain Neoplasms; Cell Division; Cell Line; Glioma; Humans; Neoplasm Proteins; Platelet-Derived Growt

1991
[Suramin inhibits the proliferation and stimulates the differentiation of tumoral cell lines HT29-D4 and C6].
    Bulletin du cancer, 1991, Volume: 78, Issue:9

    Topics: Adenocarcinoma; Animals; Cell Division; Cell Line, Transformed; Cell Transformation, Neoplastic; Col

1991
Double screening of suramin derivatives on human colon cancer cells and on neural cells provides new therapeutic agents with reduced toxicity.
    Cancer letters, 1991, Dec-01, Volume: 60, Issue:3

    Topics: Antineoplastic Agents; Cell Division; Cell Line; Cell Survival; Colonic Neoplasms; Drug Screening As

1991
Suramin inhibits proliferation of rat glioma cells and alters N-CAM cell surface expression.
    International journal of cancer, 1990, Mar-15, Volume: 45, Issue:3

    Topics: Actins; Animals; Cell Adhesion Molecules; Cell Division; Dose-Response Relationship, Drug; Drug Eval

1990
Evaluation of the effect of suramin on neural cell growth and N-CAM expression.
    Cancer research, 1990, Aug-15, Volume: 50, Issue:16

    Topics: Animals; Brain; Cell Adhesion Molecules, Neuronal; Cell Division; Cell Line; Cells, Cultured; Embryo

1990
Antiproliferative effect of trapidil, a platelet-derived growth factor antagonist, on a glioma cell line in vitro.
    Journal of neurosurgery, 1990, Volume: 73, Issue:3

    Topics: Animals; Glioma; Nimustine; Platelet-Derived Growth Factor; Pyrimidines; Suramin; Time Factors; Trap

1990