suramin and Glaucoma
suramin has been researched along with Glaucoma in 4 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Glaucoma: An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function. The consequences of the increased pressure may be manifested in a variety of symptoms, depending upon type and severity, such as excavation of the optic disk, hardness of the eyeball, corneal anesthesia, reduced visual acuity, seeing of colored halos around lights, disturbed dark adaptation, visual field defects, and headaches. (Dictionary of Visual Science, 4th ed)
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "39 patients (Group A) with ocular onchocerciasis in the Sudan-savanna of north Cameroon were given 4-6 g of suramin and followed in detail over 1-2 years." | 9.04 | Effects of suramin on ocular onchocerciasis. ( Anderson, J; de C Marshall, TF; Fuglsang, H, 1976) |
| "Suramin was applied with concentrations ranging from 10 mg/ml to 333 mg/ml once during surgery and four times following surgery." | 5.30 | Suramin inhibits wound healing following filtering procedures for glaucoma. ( Chévez-Barrios, P; Feldman, RM; Lieberman, MW; Mietz, H, 1998) |
| "39 patients (Group A) with ocular onchocerciasis in the Sudan-savanna of north Cameroon were given 4-6 g of suramin and followed in detail over 1-2 years." | 5.04 | Effects of suramin on ocular onchocerciasis. ( Anderson, J; de C Marshall, TF; Fuglsang, H, 1976) |
| "Suramin was applied with concentrations ranging from 10 mg/ml to 333 mg/ml once during surgery and four times following surgery." | 1.30 | Suramin inhibits wound healing following filtering procedures for glaucoma. ( Chévez-Barrios, P; Feldman, RM; Lieberman, MW; Mietz, H, 1998) |
Research
Studies (4)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Mietz, H | 2 |
| Chévez-Barrios, P | 1 |
| Feldman, RM | 1 |
| Lieberman, MW | 1 |
| Anderson, J | 2 |
| Fuglsang, H | 2 |
| de C Marshall, TF | 1 |
Clinical Trials (1)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Microfilarial Clearance From the Eye and Ocular Changes Associated With Ivermectin Treatment in Individuals With Onchocerciasis[NCT03517462] | 231 participants (Actual) | Interventional | 2018-08-06 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Reviews
2 reviews available for suramin and Glaucoma
| Article | Year |
|---|---|
[Filtering glaucoma operations. Can growth factor blockers replace antimetabolites?].
Topics: Antimetabolites, Antineoplastic; Cell Division; Combined Modality Therapy; Filtering Surgery; Fluoro | 1997 |
Ocular onchocerciasis.
Topics: Diethylcarbamazine; Eye; Eye Diseases; Female; Glaucoma; Humans; Iritis; Keratitis; Male; Onchocerci | 1977 |
Trials
1 trial available for suramin and Glaucoma
| Article | Year |
|---|---|
Effects of suramin on ocular onchocerciasis.
Topics: Adolescent; Adult; Anterior Chamber; Cornea; Eye Diseases; Female; Fundus Oculi; Glaucoma; Humans; I | 1976 |
Other Studies
1 other study available for suramin and Glaucoma
| Article | Year |
|---|---|
Suramin inhibits wound healing following filtering procedures for glaucoma.
Topics: Animals; Electromyography; Female; Fibrosis; Filtering Surgery; Glaucoma; Intraocular Pressure; Rabb | 1998 |