suramin and Glaucoma studies

Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.

Glaucoma: An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function. The consequences of the increased pressure may be manifested in a variety of symptoms, depending upon type and severity, such as excavation of the optic disk, hardness of the eyeball, corneal anesthesia, reduced visual acuity, seeing of colored halos around lights, disturbed dark adaptation, visual field defects, and headaches. (Dictionary of Visual Science, 4th ed)

Research Excerpts

Excerpt	Relevance	Reference
"39 patients (Group A) with ocular onchocerciasis in the Sudan-savanna of north Cameroon were given 4-6 g of suramin and followed in detail over 1-2 years."	9.04	Effects of suramin on ocular onchocerciasis. ( Anderson, J; de C Marshall, TF; Fuglsang, H, 1976)
"Suramin was applied with concentrations ranging from 10 mg/ml to 333 mg/ml once during surgery and four times following surgery."	5.30	Suramin inhibits wound healing following filtering procedures for glaucoma. ( Chévez-Barrios, P; Feldman, RM; Lieberman, MW; Mietz, H, 1998)
"39 patients (Group A) with ocular onchocerciasis in the Sudan-savanna of north Cameroon were given 4-6 g of suramin and followed in detail over 1-2 years."	5.04	Effects of suramin on ocular onchocerciasis. ( Anderson, J; de C Marshall, TF; Fuglsang, H, 1976)
"Suramin was applied with concentrations ranging from 10 mg/ml to 333 mg/ml once during surgery and four times following surgery."	1.30	Suramin inhibits wound healing following filtering procedures for glaucoma. ( Chévez-Barrios, P; Feldman, RM; Lieberman, MW; Mietz, H, 1998)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (50.00)	18.7374
1990's	2 (50.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Trial			Phase	Enrollment	Study Type	Start Date	Status
Microfilarial Clearance From the Eye and Ocular Changes Associated With Ivermectin Treatment in Individuals With Onchocerciasis[NCT03517462]				231 participants (Actual)	Interventional	2018-08-06	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
[Filtering glaucoma operations. Can growth factor blockers replace antimetabolites?]. Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 1997, Volume: 94, Issue:3 Topics: Antimetabolites, Antineoplastic; Cell Division; Combined Modality Therapy; Filtering Surgery; Fluoro	1997
Ocular onchocerciasis. Tropical diseases bulletin, 1977, Volume: 74, Issue:4 Topics: Diethylcarbamazine; Eye; Eye Diseases; Female; Glaucoma; Humans; Iritis; Keratitis; Male; Onchocerci	1977

suramin and Glaucoma

Research Excerpts

Research

Studies (4)

Authors

Clinical Trials (1)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Mietz, H	2
Chévez-Barrios, P	1
Feldman, RM	1
Lieberman, MW	1
Anderson, J	2
Fuglsang, H	2
de C Marshall, TF	1