suramin has been researched along with Filariasis in 24 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Filariasis: Infections with nematodes of the superfamily FILARIOIDEA. The presence of living worms in the body is mainly asymptomatic but the death of adult worms leads to granulomatous inflammation and permanent fibrosis. Organisms of the genus Elaeophora infect wild elk and domestic sheep causing ischemic necrosis of the brain, blindness, and dermatosis of the face.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The activity of diethylcarbamazine (DEC) and suramin (S) on Litomosoides carinii filariasis was assessed by the study of microfilaraemia in 30 cotton-rats (Sigmodon hispidus)." | 3.66 | Litomosoides carinii infection in cotton-rats: evolution of microfilaraemia before and after treatment with diethylcarbamazine and suramin. ( Carme, B; Gentilini, M; Lenoble, DR; Pontal, P; Smith, M, 1981) |
| "Suramin was shown to cause haematological changes in normal animals which became evident several days before use of the drug." | 2.64 | [Chemotherapeutic studies on litomosoides carinii infection of mastomys natalensis. 5. Alterations of haematological parameters after the administration of filaricidal compounds (author's transl)]. ( Grüner, D; Lämmler, G; Zahner, H, 1975) |
| "In our population filariasis is mainly imported from central and western Africa, especially Cameroon." | 1.26 | [Filariasis in patients returned from the tropics. Studies on 64 cases]. ( Degrémont, A; Stürchler, D, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (91.67) | 18.7374 |
| 1990's | 2 (8.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| MADELL, SH | 1 |
| SPINGARN, GL | 1 |
| FRIES, D | 1 |
| BURCH, TA | 1 |
| Lapierre, J | 1 |
| Goodwin, LG | 1 |
| Howells, RE | 1 |
| Mendis, AM | 1 |
| Bray, PG | 1 |
| Carme, B | 2 |
| Richard-Lenoble, D | 1 |
| Amgar, A | 1 |
| Danis, M | 1 |
| Gentilini, M | 2 |
| Eberhard, ML | 1 |
| Hawking, F | 2 |
| Lenoble, DR | 1 |
| Smith, M | 1 |
| Pontal, P | 1 |
| Van den Bossche, H | 1 |
| Chen, SN | 1 |
| Duarte, Z | 1 |
| Gantier, JC | 1 |
| Gayral, P | 1 |
| Denham, DA | 1 |
| McGreevy, PB | 1 |
| Lämmler, G | 3 |
| Wolf, E | 1 |
| Stürchler, D | 1 |
| Degrémont, A | 1 |
| Worms, MJ | 1 |
| Grüner, D | 1 |
| Zahner, H | 1 |
| Mak, JW | 1 |
| Lam, PL | 1 |
| Choong, MF | 1 |
| Suresh, K | 1 |
| Maeda, R | 1 |
| Hayashi, Y | 1 |
| Shibuya, T | 1 |
| Nickel, P | 1 |
| Haack, HJ | 1 |
| Widjaja, H | 1 |
| Ardanuy, U | 1 |
| Gurgel, C | 1 |
| Düwel, D | 1 |
| Loewe, H | 1 |
| Raether, W | 1 |
| Charters, AD | 1 |
| Herzog, H | 1 |
| Schütze, HR | 1 |
| Sahai, BN | 1 |
| Singh, SP | 1 |
| Srivastava, VK | 1 |
1 review available for suramin and Filariasis
| Article | Year |
|---|---|
Recent advances in research on filariasis. Chemotherapy.
Topics: Animals; Anti-Inflammatory Agents; Arsenicals; Benzimidazoles; Diethylcarbamazine; Drug Evaluation, | 1984 |
1 trial available for suramin and Filariasis
| Article | Year |
|---|---|
[Chemotherapeutic studies on litomosoides carinii infection of mastomys natalensis. 5. Alterations of haematological parameters after the administration of filaricidal compounds (author's transl)].
Topics: Animals; Anthelmintics; Benzimidazoles; Blood Sedimentation; Clinical Trials as Topic; Diethylcarbam | 1975 |
22 other studies available for suramin and Filariasis
| Article | Year |
|---|---|
Unusual thoracic manifestations in filariasis due to Loa loa; results of treatment with hetrazan and naphuride sodium.
Topics: Animals; Diethylcarbamazine; Filariasis; Humans; Loa; Sodium; Sodium, Dietary; Suramin | 1953 |
[Treatment of filariasis].
Topics: Anthelmintics; Filariasis; Suramin | 1957 |
Treatment of wuchereriasis and onchocerciasis with suramin sodium.
Topics: Animals; Filariasis; Humans; Onchocerciasis; Sodium; Suramin; Wuchereria | 1955 |
[Treatment of filariasis].
Topics: Antimony; Arsenicals; Diethylcarbamazine; Filariasis; Humans; Lymphatic System; Skin Diseases; Suram | 1967 |
The mode of action of suramin on the filarial worm Brugia pahangi.
Topics: Adenosine; Animals; Brugia; Female; Filariasis; Filarioidea; Gerbillinae; Glucose; Intestinal Mucosa | 1983 |
Litomosoides carinii infection in cotton-rats before and after treatment with diethylcarbamazine and suramin: evolution of free serum antigens.
Topics: Animals; Antigens; Arvicolinae; Blood; Diethylcarbamazine; Drug Therapy, Combination; Filariasis; Ro | 1982 |
Chemotherapy of filariasis in squirrel monkeys (Saimiri sciureus).
Topics: Animals; Anthelmintics; Arsenamide; Cebidae; Diethylcarbamazine; Dipetalonema Infections; Dithiazani | 1982 |
Chemotherapy of filariasis.
Topics: Brugia; Chemical Phenomena; Chemistry; Diethylcarbamazine; Filariasis; Humans; Loa; Onchocerca; Sura | 1981 |
Litomosoides carinii infection in cotton-rats: evolution of microfilaraemia before and after treatment with diethylcarbamazine and suramin.
Topics: Animals; Arvicolinae; Blood; Diethylcarbamazine; Drug Therapy, Combination; Filariasis; Filarioidea; | 1981 |
A new look at the mode of action of some old and new antifilarial compounds.
Topics: Anthelmintics; Diethylcarbamazine; Filariasis; Filarioidea; Humans; Levamisole; Mebendazole; Suramin | 1981 |
Chemotherapy of filariasis.
Topics: Animals; Diethylcarbamazine; Disease Models, Animal; Filariasis; Filarioidea; Humans; Levamisole; Su | 1981 |
Activity of albendazole-ivermectin combination and other filaricidal drugs against infective larvae, preadult, microfilariae and adult worms of Molinema dessetae in the rodent Proechimys oris.
Topics: Administration, Oral; Albendazole; Animals; Diethylcarbamazine; Drug Combinations; Female; Filariasi | 1994 |
Brugian filariasis: epidemiological and experimental studies.
Topics: Aedes; Animals; Anopheles; Antigens; Brugia; Cats; Cricetinae; Culicidae; Diethylcarbamazine; Filari | 1977 |
[Chemoprophylactic activity of filaricidal compounds on litomosoides carinii infection of Mastomys natalensis (author's transl)].
Topics: Animals; Anthelmintics; Bisbenzimidazole; Diethylcarbamazine; Disease Models, Animal; Drug Evaluatio | 1977 |
[Filariasis in patients returned from the tropics. Studies on 64 cases].
Topics: Adult; Africa, Western; Diethylcarbamazine; Drug Eruptions; Eosinophilia; Female; Filariasis; Humans | 1976 |
Homidium bromide as a macrofilaricide.
Topics: Animals; Benzamidines; Diminazene; Ethidium; Female; Filariasis; Male; Phenanthridines; Quinolinium | 1978 |
Antifilarial activity of intravenous suramin and oral diethylcarbamazine citrate on subperiodic Brugia malayi in the leaf-monkey, Presbytis cristata.
Topics: Administration, Oral; Animals; Brugia; Cercopithecidae; Diethylcarbamazine; Disease Models, Animal; | 1990 |
Basic studies on the laboratory assessment of macrofilaricides using Brugia malayi in the jird, Meriones unguiculatus. 2. Establishment and evaluation of a new method of macrofilaricide assessment.
Topics: Animals; Anthelmintics; Arsenicals; Brugia; Diethylcarbamazine; Drug Evaluation, Preclinical; Elepha | 1988 |
[Potential filaricides. Suramin analogs].
Topics: Animals; Anthelmintics; Chemical Phenomena; Chemistry; Female; Filariasis; Filaricides; Male; Mice; | 1986 |
Filariasis in immigrants in Western Australia, including a case of chyluria recurring in seven pregnancies.
Topics: Adult; Aged; Australia; Chyle; Diethylcarbamazine; Female; Filariasis; Humans; India; Lymphedema; Ma | 1970 |
Chemotherapeutic studies on Litomosoides carinii infection of Mastomys natalensis. 3. The activity of drugs against adult parasites.
Topics: Animals; Anthelmintics; Drug Evaluation, Preclinical; Filariasis; Filaricides; Mice; Suramin | 1971 |
Chemotherapy of parafilariasis in bovines.
Topics: Animals; Antimony; Cattle; Cattle Diseases; Filariasis; Ketones; Suramin | 1965 |