Page last updated: 2024-11-04

suramin and Eye Diseases

suramin has been researched along with Eye Diseases in 15 studies

Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.

Eye Diseases: Diseases affecting the eye.

Research Excerpts

ExcerptRelevanceReference
"39 patients (Group A) with ocular onchocerciasis in the Sudan-savanna of north Cameroon were given 4-6 g of suramin and followed in detail over 1-2 years."9.04Effects of suramin on ocular onchocerciasis. ( Anderson, J; de C Marshall, TF; Fuglsang, H, 1976)
"Treatment of onchocerciasis with suramin in an area of vector control led to an increased incidence of optic atrophy in treated patients compared to an untreated group."7.66The risk of optic atrophy following suramin treatment of ocular onchocerciasis. ( Rolland, A; Thylefors, B, 1979)
"In 1959 a population of 638 persons over the age of seven years, suffering from heavy endemic onchocerciasis in the Sudan-Savannah of West Africa was examined, and approximately half were allotted to a group for treatment with suramin (up to a total of 4-2 g for healthy adults)."7.65The natural history of ocular onchocerciasis over a period of 14--15 years and the effect on this of a single course of suramin therapy. ( Budden, FH, 1976)
"39 patients (Group A) with ocular onchocerciasis in the Sudan-savanna of north Cameroon were given 4-6 g of suramin and followed in detail over 1-2 years."5.04Effects of suramin on ocular onchocerciasis. ( Anderson, J; de C Marshall, TF; Fuglsang, H, 1976)
"Treatment of onchocerciasis with suramin in an area of vector control led to an increased incidence of optic atrophy in treated patients compared to an untreated group."3.66The risk of optic atrophy following suramin treatment of ocular onchocerciasis. ( Rolland, A; Thylefors, B, 1979)
"In 1959 a population of 638 persons over the age of seven years, suffering from heavy endemic onchocerciasis in the Sudan-Savannah of West Africa was examined, and approximately half were allotted to a group for treatment with suramin (up to a total of 4-2 g for healthy adults)."3.65The natural history of ocular onchocerciasis over a period of 14--15 years and the effect on this of a single course of suramin therapy. ( Budden, FH, 1976)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-199014 (93.33)18.7374
1990's1 (6.67)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Rougemont, A1
Hien, M1
Thylefors, B5
Prost, A1
Rolland, A4
Hemady, RK1
Sinibaldi, VJ1
Eisenberger, MA1
Anderson, J4
Fuglsang, H4
Vingtain, P1
Lucot, J1
Chovet, M1
Budden, FH1
de C Marshall, TF1
Toufic, N1
Scheie, HG1
Shannon, RE1
Yanoff, M1
Gornig, H1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Microfilarial Clearance From the Eye and Ocular Changes Associated With Ivermectin Treatment in Individuals With Onchocerciasis[NCT03517462]231 participants (Actual)Interventional2018-08-06Completed
Safety and Efficacy of Combination Therapy With Ivermectin, Diethylcarbamazine, and Albendazole (IDA) for Individuals With Onchocerciasis[NCT04188301]Phase 2154 participants (Actual)Interventional2019-12-06Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Effectiveness of Killing Adult Female Worms

The effectiveness of three treatment regimens for killing adult female O. volvulus worms based on the percentage of all adult female worms in nodules that are alive 18 months after treatment. (NCT04188301)
Timeframe: 18 months following treatment

InterventionFemale worms in nodule (Count of Units)
IVM + ALB127
IDA x 1 Dose142
IDA x 3 Doses159

Percentage of Worms Killed Across Study Arms

The effect of three treatment regimens for killing adult female O. volvulus worms will be compared based on the percentage of all adult female worms in nodules that are alive with embryos in the uterus 18 months after treatment. (NCT04188301)
Timeframe: 18 months following treatment.

InterventionFemale worms in nodules (Count of Units)
IVM + ALB127
IDA x 1 Dose142
IDA x 3 Doses159

Percentage of Worms Sterilized Across Study Arms

The effect of three treatment regimens for sterilizing adult female O. volvulus worms will be compared based on the percentage of all adult female worms that are fertile in the nodules 18 months after treatment. (NCT04188301)
Timeframe: 18 months following treatment.

InterventionFemale worms with intact uterus (Count of Units)
IVM + ALB41
IDA x 1 Dose40
IDA x 3 Doses34

Rates of Ocular Adverse Events (Any Grade) by Treatment Group

Rates of ocular adverse events of any grade within 3 months will be compared by treatment group. (NCT04188301)
Timeframe: within 3 months of treatment with IDA

InterventionParticipants (Count of Participants)
IVM + ALB4
IDA x 1 Dose4
IDA x 3 Doses3

Rates of SAEs by Treatment Group in Those With Intraocular Microfilariae Just Prior to Treatment With IDA

Rates of adverse events grade 3 or higher that occur within 7 days of treatment in the subset of participants who have intraocular microfilariae just prior to treatment with IDA will be compared by treatment group. (NCT04188301)
Timeframe: within 7 days following end of treatment

InterventionParticipants (Count of Participants)
IVM + ALB0
IDA x 1 Dose0
IDA x 3 Doses0

Rates of Severe Adverse Events (SAEs) Across Study Arms

Rates of severe adverse events (grade 3 or higher) following 1-day or 3-day triple drug treatment will be compared against those of the comparator regimen of 1 day of IVM/ALB. (NCT04188301)
Timeframe: Within 7 days following end of treatment

InterventionParticipants (Count of Participants)
IVM + ALB0
IDA x 1 Dose0
IDA x 3 Doses0

Effectiveness for Preventing Reappearance of Microfilariae in the Skin by Skin Snips

The effectiveness of three treatment regimens for preventing reappearance of microfilariae in the skin as determined by skin snips at 12 and 18 months after treatment will be compared by treatment arm. Measured by the presence of microfilariae in skin snips. (NCT04188301)
Timeframe: Baseline, 12 months, and 18 months following treatment

,,
InterventionCount of microfilarae+ participants (Number)
BaselineMonth 12Month 18
IDA x 1 Dose62115
IDA x 3 Doses02117
IVM + ALB72320

Effectiveness of Clearing Microfilariae From Skin by Skin Snips

The effectiveness of three treatment regimens for complete clearance of microfilariae from the skin as determined by skin snips at 3, 12, and 18 months after treatment with IDA will be compared by treatment arm. (NCT04188301)
Timeframe: Baseline, 3 months, 12 months, & 18 months following treatment.

,,
InterventionCount of Skin Microfilaria (Geometric Mean)
BaselineMonth 3Month 12Month 18
IDA x 1 Dose1.732.59.0
IDA x 3 DosesNA2.14.78.6
IVM + ALB3.11.94.97.0

Reviews

1 review available for suramin and Eye Diseases

ArticleYear
Ocular onchocerciasis.
    Tropical diseases bulletin, 1977, Volume: 74, Issue:4

    Topics: Diethylcarbamazine; Eye; Eye Diseases; Female; Glaucoma; Humans; Iritis; Keratitis; Male; Onchocerci

1977

Trials

1 trial available for suramin and Eye Diseases

ArticleYear
Effects of suramin on ocular onchocerciasis.
    Tropenmedizin und Parasitologie, 1976, Volume: 27, Issue:3

    Topics: Adolescent; Adult; Anterior Chamber; Cornea; Eye Diseases; Female; Fundus Oculi; Glaucoma; Humans; I

1976

Other Studies

13 other studies available for suramin and Eye Diseases

ArticleYear
[Treatment of onchocerciasis with low, increasing doses of suramin in hyperendemic communities of Western Africa: 2. Clinical parasitologic and ophthalmologic results in a zone where transmission is controlled].
    Bulletin of the World Health Organization, 1984, Volume: 62, Issue:2

    Topics: Adolescent; Adult; Burkina Faso; Child; Child, Preschool; Eye Diseases; Female; Humans; Infant; Infa

1984
Basis for treatment and prevention of ocular onchocerciasis.
    Revue internationale du trachome et de pathologie oculaire tropicale et subtropicale et de sante publique : organe de la Ligue contre le trachome avec la collaboration de l'International Organization against Trachoma et des organisation..., 1982, Issue:4

    Topics: Adolescent; Adrenal Cortex Hormones; Adult; Child; Child, Preschool; Diethylcarbamazine; Drug Therap

1982
[Basis of the treatment and prevention of ocular onchocerciasis].
    Revue internationale du trachome et de pathologie oculaire tropicale et subtropicale et de sante publique : organe de la Ligue contre le trachome avec la collaboration de l'International Organization against Trachoma et des organisation..., 1982, Issue:4

    Topics: Adolescent; Adrenal Cortex Hormones; Adult; Africa; Antinematodal Agents; Diethylcarbamazine; Drug T

1982
Ocular symptoms and signs associated with suramin sodium treatment for metastatic cancer of the prostate.
    American journal of ophthalmology, 1996, Volume: 121, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Corneal Diseases; Eye Diseases; Humans; Infus

1996
Ocular onchocerciasis.
    Bulletin of the World Health Organization, 1978, Volume: 56, Issue:1

    Topics: Diethylcarbamazine; Drug Therapy, Combination; Eye Diseases; Humans; Insect Control; Onchocerciasis;

1978
The risk of optic atrophy following suramin treatment of ocular onchocerciasis.
    Bulletin of the World Health Organization, 1979, Volume: 57, Issue:3

    Topics: Eye Diseases; Female; Humans; Male; Onchocerciasis; Optic Atrophy; Suramin

1979
[Therapy of ocular onchocerciasis].
    Revue internationale du trachome et de pathologie oculaire tropicale et subtropicale : organe de la Ligue contre le trachome avec la collaboration de l'International Organization against Trachoma et des organisations nationales et inter..., 1979, Volume: 56, Issue:3-4

    Topics: Anthelmintics; Diethylcarbamazine; Eye Diseases; Filaricides; Humans; Keratitis; Onchocerciasis; Sur

1979
Further observations on the relationship between ocular onchocerciasis and the head nodule, and on the possible benefit of nodulectomy.
    The British journal of ophthalmology, 1978, Volume: 62, Issue:7

    Topics: Cameroon; Dermatologic Surgical Procedures; Diethylcarbamazine; Eye; Eye Diseases; Female; Head; Hum

1978
Further observations on the relationship between ocular onchocerciasis and the head nodule, and on the possible benefit of nodulectomy.
    The British journal of ophthalmology, 1978, Volume: 62, Issue:7

    Topics: Cameroon; Dermatologic Surgical Procedures; Diethylcarbamazine; Eye; Eye Diseases; Female; Head; Hum

1978
Further observations on the relationship between ocular onchocerciasis and the head nodule, and on the possible benefit of nodulectomy.
    The British journal of ophthalmology, 1978, Volume: 62, Issue:7

    Topics: Cameroon; Dermatologic Surgical Procedures; Diethylcarbamazine; Eye; Eye Diseases; Female; Head; Hum

1978
Further observations on the relationship between ocular onchocerciasis and the head nodule, and on the possible benefit of nodulectomy.
    The British journal of ophthalmology, 1978, Volume: 62, Issue:7

    Topics: Cameroon; Dermatologic Surgical Procedures; Diethylcarbamazine; Eye; Eye Diseases; Female; Head; Hum

1978
Further studies on the treatment of ocular onchocerciasis with diethylcarbamazine and suramin.
    The British journal of ophthalmology, 1978, Volume: 62, Issue:7

    Topics: Adolescent; Adult; Betamethasone; Child; Diethylcarbamazine; Drug Therapy, Combination; Eye Diseases

1978
The natural history of ocular onchocerciasis over a period of 14--15 years and the effect on this of a single course of suramin therapy.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 1976, Volume: 70, Issue:5-6

    Topics: Adolescent; Adult; Child; Eye Diseases; Female; Follow-Up Studies; Humans; Male; Microfilariae; Onch

1976
[The therapeutic difficulties of ocular onchocerciasis].
    Archives d'ophtalmologie et revue generale d'ophtalmologie, 1969, Volume: 29, Issue:11

    Topics: Arsenicals; Diethylcarbamazine; Eye Diseases; Humans; Onchocerciasis; Optic Nerve; Suramin; Thiabend

1969
Onchocerciasis (ocular).
    Annals of ophthalmology, 1971, Volume: 3, Issue:7

    Topics: Biopsy; Child; Diagnosis, Differential; Diethylcarbamazine; Diphenhydramine; Eye Diseases; Female; H

1971
[Eye involvement in onchocerciasis].
    Klinische Monatsblatter fur Augenheilkunde, 1967, Volume: 151, Issue:1

    Topics: Adult; Biopsy; Complement Fixation Tests; Cornea; Diagnosis, Differential; Diethylcarbamazine; Eye D

1967