suramin has been researched along with Experimental Neoplasms in 8 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Suramin is a synthetic anticancer agent that works, in part, by blocking the binding of growth factors to their receptors." | 1.30 | Inhibition of growth factor mitogenicity and growth of tumor cell xenografts by a sulfonated distamycin A derivative. ( Calabresi, P; Chen, TM; Chu, MY; Epstein, MH; Finch, PW; Friedman, S; Lipsky, MH; Maciag, T; Yee, LK, 1997) |
| "(c) Suramin-treated rats had markedly decreased lymphocyte stimulation, pointing to a possible immunosuppressive effect." | 1.30 | Effects of suramin on anastomotic colon tumors in a rat model. ( De Clerck, LS; Dirix, L; Eyskens, E; Hendriks, J; Hubens, A; Hubens, G; Lauwers, P; Schuerwegh, A; Stevens, WJ; Van Marck, E; Vermeulen, P, 1999) |
| "Wilms tumor is a common embryonic tumor in childhood." | 1.29 | Autocrine regulation of growth by insulin-like growth factor (IGF)-II mediated by type I IGF-receptor in Wilms tumor cells. ( Qing, RQ; Ruelicke, T; Schmitt, S; Schoenle, EJ; Stallmach, T, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 6 (75.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Park, J | 1 |
| Hwang, SR | 1 |
| Choi, JU | 1 |
| Alam, F | 1 |
| Byun, Y | 1 |
| Toshkov, A | 1 |
| Trifonov, S | 1 |
| Neĭchev, Kh | 1 |
| Aleksandrov, I | 1 |
| Opŭlchenova, G | 1 |
| Gil, M | 1 |
| Skopińska-Rózewska, E | 1 |
| Radomska, D | 1 |
| Demkow, U | 1 |
| Skurzak, H | 1 |
| Rochowska, M | 1 |
| Beuth, J | 1 |
| Roszkowski, K | 1 |
| Lelièvre, S | 1 |
| Larsen, AK | 1 |
| Qing, RQ | 1 |
| Schmitt, S | 1 |
| Ruelicke, T | 1 |
| Stallmach, T | 1 |
| Schoenle, EJ | 1 |
| Strassmann, G | 1 |
| Kambayashi, T | 1 |
| Finch, PW | 1 |
| Yee, LK | 1 |
| Chu, MY | 1 |
| Chen, TM | 1 |
| Lipsky, MH | 1 |
| Maciag, T | 1 |
| Friedman, S | 1 |
| Epstein, MH | 1 |
| Calabresi, P | 1 |
| Lauwers, P | 1 |
| Hubens, G | 1 |
| Hendriks, J | 1 |
| Vermeulen, P | 1 |
| Schuerwegh, A | 1 |
| Stevens, WJ | 1 |
| De Clerck, LS | 1 |
| Dirix, L | 1 |
| Van Marck, E | 1 |
| Hubens, A | 1 |
| Eyskens, E | 1 |
1 review available for suramin and Experimental Neoplasms
| Article | Year |
|---|---|
Inhibition of experimental cancer cachexia by anti-cytokine and anti-cytokine-receptor therapy.
Topics: Animals; Antibodies; Cachexia; Cytokines; Humans; Interleukin-6; Mice; Mice, Inbred Strains; Neoplas | 1995 |
7 other studies available for suramin and Experimental Neoplasms
| Article | Year |
|---|---|
Self-assembled nanocomplex of PEGylated protamine and heparin-suramin conjugate for accumulation at the tumor site.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Carriers; Heparin, Low-Molecular-Weight; Mice | 2018 |
In vivo effect of naganol on the cytostatic activity of rat peritoneal macrophages.
Topics: Animals; Ascitic Fluid; Carcinoma, Squamous Cell; Corynebacterium Infections; Cytotoxicity, Immunolo | 1981 |
Effect of purinergic receptor antagonists suramin and theobromine on tumor-induced angiogenesis in BALB/c mice.
Topics: Animals; Carcinoma; Injections, Subcutaneous; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Neopl | 1993 |
[Acquisition of resistance to suramin in the cells of fibrosarcoma in Chinese hamsters accompanied by morphologic modification and increased metastatic capacity].
Topics: Animals; Cricetinae; Cricetulus; Drug Resistance; Fibrosarcoma; Neoplasm Metastasis; Neoplasms, Expe | 1994 |
Autocrine regulation of growth by insulin-like growth factor (IGF)-II mediated by type I IGF-receptor in Wilms tumor cells.
Topics: Animals; Binding Sites; Cell Division; Dose-Response Relationship, Drug; Humans; Insulin-Like Growth | 1996 |
Inhibition of growth factor mitogenicity and growth of tumor cell xenografts by a sulfonated distamycin A derivative.
Topics: 3T3 Cells; Animals; Antineoplastic Agents; Cell Line, Transformed; Cells, Cultured; Cytokines; Dista | 1997 |
Effects of suramin on anastomotic colon tumors in a rat model.
Topics: Adenocarcinoma; Anastomosis, Surgical; Animals; Antineoplastic Agents; Cell Survival; Colon; Colonic | 1999 |