suramin has been researched along with Experimental Leukemia in 3 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Suramin treatment led to a significant, but transient, disappearance of p24 antigen and did not affect the titre of anti-p24 and anti-gp51 antibodies." | 1.28 | Treatment of bovine leukaemia virus-infected sheep with suramin: an animal model for the development of antiretroviral compounds. ( Burkhardt, H; De Clercq, E; Karge, E; Rosenthal, HA; Rosenthal, S, 1989) |
| "Suramin is an active antiretroviral agent whose effect on retroviral propagation is reversible." | 1.27 | Suppression of retroviral propagation and disease by suramin in murine systems. ( Broder, S; Haseltine, WA; Rossoni, LD; Ruprecht, RM, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zvetkova, E | 1 |
| Chowdhury, I | 1 |
| Rusev, R | 1 |
| Janeva, E | 1 |
| Nikolova, E | 1 |
| Tzenov, I | 1 |
| Trifonov, S | 1 |
| Ruprecht, RM | 1 |
| Rossoni, LD | 1 |
| Haseltine, WA | 1 |
| Broder, S | 1 |
| Burkhardt, H | 1 |
| Rosenthal, S | 1 |
| Rosenthal, HA | 1 |
| Karge, E | 1 |
| De Clercq, E | 1 |
3 other studies available for suramin and Experimental Leukemia
| Article | Year |
|---|---|
Influence of the immunomodulators suramin, MER and clenbuterol on the haemopoiesis of mice with virus-induced Rauscher leukemia.
Topics: Adjuvants, Immunologic; Animals; BCG Vaccine; Bone Marrow; Clenbuterol; Drug Evaluation, Preclinical | 1993 |
Suppression of retroviral propagation and disease by suramin in murine systems.
Topics: Animals; Female; Hematopoietic Stem Cells; Leukemia, Experimental; Mice; Mice, Inbred BALB C; Rausch | 1985 |
Treatment of bovine leukaemia virus-infected sheep with suramin: an animal model for the development of antiretroviral compounds.
Topics: Animals; Antiviral Agents; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Leukemia Vi | 1989 |