suramin has been researched along with Experimental Hepatoma in 5 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A new therapeutic strategy for treating metastasis in hepatocellular carcinoma (HCC) has entailed the use of antiangiogenic agents such as suramin, BB-94 (Batimastat), TNP-470, and carboxyamido-triazole (CAI, a synthetic inhibitor of non-excitable calcium channels that reversibly inhibits angiogenesis)." | 1.30 | Effect of antiangiogenic agents on experimental animal models of hepatocellular carcinoma. ( Bu, W; Li, XM; Qin, LX; Tang, ZY; Xia, JL, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (80.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tayel, A | 1 |
| Abd El Galil, KH | 1 |
| Ebrahim, MA | 1 |
| Ibrahim, AS | 1 |
| El-Gayar, AM | 1 |
| Al-Gayyar, MM | 1 |
| Baumann, H | 1 |
| Strassmann, G | 1 |
| Wang, Y | 1 |
| Roman, R | 1 |
| Lidofsky, SD | 1 |
| Fitz, JG | 1 |
| Qin, LX | 1 |
| Tang, ZY | 1 |
| Li, XM | 1 |
| Bu, W | 1 |
| Xia, JL | 1 |
| Bai, L | 1 |
| Naomoto, Y | 1 |
| Miyazaki, M | 1 |
| Orita, K | 1 |
| Namba, M | 1 |
5 other studies available for suramin and Experimental Hepatoma
| Article | Year |
|---|---|
Suramin inhibits hepatic tissue damage in hepatocellular carcinoma through deactivation of heparanase enzyme.
Topics: Adult; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Female; Glucuronidase; Heparan Sul | 2014 |
Suramin inhibits the stimulation of acute phase plasma protein genes by IL-6-type cytokines in rat hepatoma cells.
Topics: Acute-Phase Proteins; Animals; Cytokines; Gene Expression; Humans; In Vitro Techniques; Interleukin- | 1993 |
Autocrine signaling through ATP release represents a novel mechanism for cell volume regulation.
Topics: Adenosine Triphosphate; Animals; Apyrase; Cell Membrane; Chloride Channels; Chlorides; Hypotonic Sol | 1996 |
Effect of antiangiogenic agents on experimental animal models of hepatocellular carcinoma.
Topics: Animals; Antineoplastic Agents; Cell Division; Cyclohexanes; Liver Neoplasms, Experimental; Mice; Mi | 1999 |
Antiproliferative effects of suramin on human cancer cells in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Cell Division; Humans; Liver Neoplasms, Experimental; Mice; Mice, Nu | 1992 |