suramin has been researched along with Esophageal and Gastric Varices in 1 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Esophageal and Gastric Varices: Dilated blood vessels in the ESOPHAGUS or GASTRIC FUNDUS that shunt blood from the portal circulation (PORTAL SYSTEM) to the systemic venous circulation. Often they are observed in individuals with portal hypertension (HYPERTENSION, PORTAL).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Suramin has recently been shown to inhibit the activity of the duck hepatitis B virus DNA polymerase (DHBV DNAp) in vitro." | 7.67 | Suramin treatment for chronic active hepatitis B--toxic and ineffective. ( Anderson, MG; Coleman, JC; Loke, RH; Murray-Lyon, IM; Tsiquaye, KN; Zuckerman, AJ, 1987) |
| "Suramin has recently been shown to inhibit the activity of the duck hepatitis B virus DNA polymerase (DHBV DNAp) in vitro." | 3.67 | Suramin treatment for chronic active hepatitis B--toxic and ineffective. ( Anderson, MG; Coleman, JC; Loke, RH; Murray-Lyon, IM; Tsiquaye, KN; Zuckerman, AJ, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Loke, RH | 1 |
| Anderson, MG | 1 |
| Coleman, JC | 1 |
| Tsiquaye, KN | 1 |
| Zuckerman, AJ | 1 |
| Murray-Lyon, IM | 1 |
1 other study available for suramin and Esophageal and Gastric Varices
| Article | Year |
|---|---|
Suramin treatment for chronic active hepatitis B--toxic and ineffective.
Topics: Esophageal and Gastric Varices; Gastrointestinal Hemorrhage; Hepatic Encephalopathy; Hepatitis B; He | 1987 |