suramin has been researched along with Encapsulating Peritoneal Sclerosis in 2 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In the rat model of peritoneal fibrosis induced by CG, suramin or saline was administered at day 21 and 28." | 1.51 | Delayed administration of suramin attenuates peritoneal fibrosis in rats. ( Liu, N; Shao, X; Sharif, S; Xiong, C; Zhuang, S; Zou, H, 2019) |
| "Suramin was also effective in blocking CG-induced phosphorylation of inhibitor of κB (IκB) and nuclear factor (NF)-κBp65, expression of several inflammatory cytokines, and infiltration of macrophages in the peritoneum." | 1.40 | Suramin inhibits the development and progression of peritoneal fibrosis. ( Fang, L; Liu, N; Xiong, C; Yan, H; Zhuang, S, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xiong, C | 2 |
| Liu, N | 2 |
| Shao, X | 1 |
| Sharif, S | 1 |
| Zou, H | 1 |
| Zhuang, S | 2 |
| Fang, L | 1 |
| Yan, H | 1 |
2 other studies available for suramin and Encapsulating Peritoneal Sclerosis
| Article | Year |
|---|---|
Delayed administration of suramin attenuates peritoneal fibrosis in rats.
Topics: Actins; Animals; Antineoplastic Agents; Chemokine CCL2; Chlorhexidine; Collagen Type I; ErbB Recepto | 2019 |
Suramin inhibits the development and progression of peritoneal fibrosis.
Topics: Actins; Angiogenesis Inducing Agents; Animals; Collagen Type I; Cytokines; Disease Models, Animal; D | 2014 |